On June 5, GSK rose 3.01% in regular trading, trading at $51.22/share, with trading volume of $170 million.
The move was driven by positive Phase III clinical data for Bepirovirsen, GSK's hepatitis B functional cure candidate developed in collaboration with China Grand Pharmaceutical's subsidiary Chia Tai Tianqing. Data showed an overall functional cure rate of 19% after six months of treatment, with 26% in patients with low baseline viral activity and 35% in the Chinese subgroup with HBsAg≤1000 IU/mL, versus 0% for placebo.
Additionally, the drug has been resubmitted for marketing approval in China and accepted for priority review, with GSK expecting a regulatory decision from China's NMPA in the first half of next year. Bepirovirsen is also under review by regulators in the US, Europe, and Japan. Jefferies projects peak annual sales of $1.5 billion, while GSK's internal estimates are more optimistic, potentially exceeding $2.7 billion.
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