On October 24, Tango Therapeutics Inc. fell 12.1% in regular trading, trading at $24.555/share, with turnover of $254 million.
The move followed updated phase 1/2 data for the company’s vopimetostat-daraxonrasib combination in previously treated pancreatic cancer, where strong efficacy metrics were offset by notable treatment-related toxicity, contributing to a divided market response.
Among 22 evaluable patients, the study reported an 82% objective response rate, 100% disease control, and an 88% nine-month progression-free survival rate, with median progression-free survival not yet reached. However, 40% of safety-evaluable patients experienced grade 3 treatment-related adverse events. The company also said it plans to start a global randomized phase 3 trial in the first half of next year for MTAP-deleted pancreatic cancer, but the early-stage nature of the dataset and safety profile appear to have tempered investor enthusiasm.
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