Viking Therapeutics (VKTX) stock surged 5.79% in the last 24 hours, driven by the positive results from the Phase 2b clinical trial of its drug candidate VK2809 for the treatment of non-alcoholic steatohepatitis (NASH).
The Phase 2b VOYAGE trial met both its primary and secondary endpoints, demonstrating statistically significant reductions in liver fat content at Week 12 and Week 52. Patients receiving VK2809 showed mean relative reductions in liver fat ranging from 37% to 55% at Week 52, with 64% to 88% of patients achieving at least a 30% reduction.
Importantly, VK2809 also showed impressive histologic results, with 63% to 75% of treated patients achieving NASH resolution without worsening of fibrosis, compared to 29% for placebo. Additionally, 44% to 57% of VK2809-treated patients demonstrated improvement in fibrosis without worsening of NASH, versus 34% for placebo. The drug demonstrated encouraging safety and tolerability, with the majority of treatment-related adverse events reported as mild or moderate.
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