Viking Therapeutics (NASDAQ: VKTX) witnessed a significant 6.74% surge in its stock price during the pre-market trading session on Wednesday. This rally can be attributed to the company's announcement of positive results from the Phase 2b clinical trial of its investigational drug VK2809 for the treatment of non-alcoholic steatohepatitis (NASH) and metabolic dysfunction-associated steatohepatitis (MASH).
The Phase 2b VOYAGE study met both its primary and secondary endpoints, demonstrating statistically significant reductions in liver fat content at Week 12 and Week 52. Patients receiving VK2809 showed mean relative reductions in liver fat ranging from 37% to 55% at Week 52, with 64% to 88% of patients achieving at least a 30% reduction.
Notably, the trial also reported impressive histologic results. Between 63% and 75% of VK2809-treated patients achieved resolution of NASH without worsening of fibrosis, compared to only 29% for the placebo group. Additionally, 44% to 57% of patients demonstrated improvement in fibrosis without worsening of NASH, versus 34% for placebo. These findings highlight VK2809's potential to address the underlying causes of NASH and associated liver damage.
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