Clover Biopharmaceuticals (02197) has announced that patient enrollment for the Australian Phase II clinical trial of its proprietary combined respiratory vaccine candidates, SCB‑1022 (RSV+hMPV) and SCB‑1033 (RSV+hMPV+PIV3), has been completed. Developed using the company's validated protein trimer (Trimer‑Tag) vaccine technology platform, the RSV combined vaccine candidates utilize a prefusion F (Pre-F) trimer subunit vaccine protein antigen. The ongoing Phase II study for Clover's RSV vaccine candidates is a randomized, observer-blinded, multicenter clinical trial that enrolled 420 elderly subjects (aged 60–85 years) in Australia. Participants were randomly assigned to receive SCB‑1022, SCB‑1033, or a placebo. The trial is evaluating the safety, reactogenicity, and immunogenicity of the company's RSV combination vaccine candidates, with preliminary results expected in the third quarter of 2026.
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