Shares of Genscript Biotech (01548) experienced a sharp decline, dropping more than 10% at one point during the trading session.
At the time of writing, the stock was down 8.37% to HK$11.93, with a trading turnover reaching HK$295 million.
The market movement follows an announcement from the company's associate firm, Legend Biotech, regarding initial clinical proof-of-concept data for its investigational in vivo CD19/CD20 dual-target CAR-T cell therapy, LB2501, for patients with relapsed/refractory B-cell non-Hodgkin lymphoma.
These findings were presented at the latest breakthrough session of the 2026 European Hematology Association Congress.
In an ongoing Phase I study, patients with R/R B-NHL who received a single infusion achieved a 100% objective response rate and an 83.3% complete response rate at the second dose level.
All responses were reported to be ongoing at the time of the data cutoff.
The therapy also demonstrated a favorable safety profile, with no reports of dose-limiting toxicities, serious adverse events, immune effector cell-associated neurotoxicity syndrome, or deaths.
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