Summit lead asset beats Merck’s Keytruda in a first in lung cancer

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Summit Therapeutics (NASDAQ:SMMT) traded higher on Thursday after the company said its lead asset, ivonescimab, became the first to outperform Merck’s (NYSE:MRK) ant-PD1 immunotherapy Keytruda in a ...

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Merck  shares reached a session low in reaction, while Summit  witnessed over threefold rise in value.  Citing interim data from its China-based HARMONi-2 Phase 3 trial, Summit  said ivonescimab, a bispecific antibody blocking the PD-1 receptor in cancer cells, met its primary endpoint of progression-free survival  as a first-line therapy. HARMONi-2, conducted by its Chinese partner Akeso , was designed to evaluate ivonescimab against Keytruda, also known as pembrolizumab, in patients with locally advanced or metastatic NSCLC. Florida-based Summit  said the PFS advantage was seen across different patient groups, including those with low or high PD-L1 expression and squamous or non-squamous histologies. 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Merck (MRK) shares reached a session low in reaction, while Summit (SMMT) witnessed over threefold rise in value.  Citing interim data from its China-based HARMONi-2 Phase 3 trial, Summit (SMMT) said ivonescimab, a bispecific antibody blocking the PD-1 receptor in cancer cells, met its primary endpoint of progression-free survival (PFS) as a first-line therapy. HARMONi-2, conducted by its Chinese partner Akeso (OTCPK:AKESF), was designed to evaluate ivonescimab against Keytruda, also known as pembrolizumab, in patients with locally advanced or metastatic NSCLC. Florida-based Summit (SMMT) said the PFS advantage was seen across different patient groups, including those with low or high PD-L1 expression and squamous or non-squamous histologies. Full results from the trial are expected at a medical event later this year. “This is an historic moment for ivonescimab, Team Summit, our partners at Akeso, and most importantly, we believe this is the beginning of a paradigm change for treatment options for patients living with cancer,” CEO Robert Duggan remarked.","kind":"highlight","is_publish_news":true,"is_publish_highlight":false,"is_publish_live":false,"is_publish_wemedia":null,"editions":null,"column":"","sentiment":"0","news_tag":"","news_rank":0,"symbols":[],"gpt_button":1},"commentList":[],"isCommentEnd":true,"newsSizeData":{"likeSize":0,"commentSize":0,"repostSize":0,"favoriteSize":0,"likeStatus":false,"favoriteStatus":false},"APP":{"userAgent":"Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)","isDev":false,"isTTM":true,"deviceId":"web-server-community-laohu8-v3","version":"4.29.3","shortVersion":"4.29.3","platform":"web","vendor":"web","appName":"ttm","isIOS":false,"isAndroid":false,"isTiger":false,"isTHS":false,"isWeiXin":false,"isWeiXinMini":false,"isWeiBo":false,"isQQ":false,"isBaiduSwan":false,"isBaiduBox":false,"isDingTalk":false,"isToutiao":false,"isOnePlus":false,"isHuaWei":false,"isXiaomi":false,"isXiaomiWebView":false,"isOppo":false,"isVivo":false,"isSamsung":false,"isMobile":false},"href":"/m/news/2439367487"}