Summit lead asset beats Merck’s Keytruda in a first in lung cancer

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Summit Therapeutics (NASDAQ:SMMT) traded higher on Thursday after the company said its lead asset, ivonescimab, became the first to outperform Merck’s (NYSE:MRK) ant-PD1 immunotherapy Keytruda in a ...

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}\n.meta {color:#5e5c6d;font-size:13px;margin:0 0 .5em; }\na{text-decoration:none; color:#2a4b87;}\n.meta .head { display: inline-block; overflow: hidden}\n.head .h-thumb { width: 30px; height: 30px; margin: 0; padding: 0; border-radius: 50%; float: left;}\n.head .h-content { margin: 0; padding: 0 0 0 9px; float: left;}\n.head .h-name {font-size: 13px; color: #eee; margin: 0;}\n.head .h-time {font-size: 11px; color: #7E829C; margin: 0;line-height: 11px;}\n.small {font-size: 12.5px; display: inline-block; transform: scale(0.9); -webkit-transform: scale(0.9); transform-origin: left; -webkit-transform-origin: left;}\n.smaller {font-size: 12.5px; display: inline-block; transform: scale(0.8); -webkit-transform: scale(0.8); transform-origin: left; -webkit-transform-origin: left;}\n.bt-text {font-size: 12px;margin: 1.5em 0 0 0}\n.bt-text p {margin: 0}\n</style>\n</head>\n<body>\n<div class=\"wrapper\">\n<header>\n<h2 class=\"title\">\nSummit lead asset beats Merck’s Keytruda in a first in lung cancer\n</h2>\n\n<h4 class=\"meta\">\n\n\n2024-05-31 03:12 GMT+8&nbsp;&nbsp;&nbsp;<a href=https://seekingalpha.com/news/4111700-summit-stock-gains-lead-asset-beats-keytruda><strong>seekingalpha</strong></a>\n\n\n</h4>\n\n</header>\n<article>\n<div>\n<p>Summit Therapeutics (NASDAQ:SMMT) traded higher on Thursday after the company said its lead asset, ivonescimab, became the first to outperform Merck’s (NYSE:MRK) ant-PD1 immunotherapy Keytruda in a ...</p>\n\n<a href=\"https://seekingalpha.com/news/4111700-summit-stock-gains-lead-asset-beats-keytruda\">Source Link</a>\n\n</div>\n\n\n</article>\n</div>\n</body>\n</html>\n","isBrief":false,"type":0,"news_type":1,"symbol":"SG9999013999.USD","symbol_name":"UOB UNITED GLOBAL HEALTHCARE FUND (USDHDG) INC","start_time":0,"source_url":"https://seekingalpha.com/news/4111700-summit-stock-gains-lead-asset-beats-keytruda","article_id":"2439367487","we_media_id":null,"thumbnails":["https://static.seekingalpha.com/cdn/s3/uploads/getty_images/1623197589/image_1623197589.jpg"],"rights":null,"url":"https://stock-news.laohu8.com/highlight/detail?id=2439367487","pubTimestamp":1717096322,"sourceInfo":{"source_id":"seekingalpha","name":"Seeking Alpha"},"weMediaInfo":null,"summary":"Summit Therapeutics  traded higher on Thursday after the company said its lead asset, ivonescimab, became the first to outperform Merck’s  ant-PD1 immunotherapy Keytruda in a late-stage trial for non-small cell lung cancer . Merck  shares reached a session low in reaction, while Summit  witnessed over threefold rise in value.  Citing interim data from its China-based HARMONi-2 Phase 3 trial, Summit  said ivonescimab, a bispecific antibody blocking the PD-1 receptor in cancer cells, met its primary endpoint of progression-free survival  as a first-line therapy. HARMONi-2, conducted by its Chinese partner Akeso , was designed to evaluate ivonescimab against Keytruda, also known as pembrolizumab, in patients with locally advanced or metastatic NSCLC. Florida-based Summit  said the PFS advantage was seen across different patient groups, including those with low or high PD-L1 expression and squamous or non-squamous histologies. 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Merck (MRK) shares reached a session low in reaction, while Summit (SMMT) witnessed over threefold rise in value.  Citing interim data from its China-based HARMONi-2 Phase 3 trial, Summit (SMMT) said ivonescimab, a bispecific antibody blocking the PD-1 receptor in cancer cells, met its primary endpoint of progression-free survival (PFS) as a first-line therapy. HARMONi-2, conducted by its Chinese partner Akeso (OTCPK:AKESF), was designed to evaluate ivonescimab against Keytruda, also known as pembrolizumab, in patients with locally advanced or metastatic NSCLC. Florida-based Summit (SMMT) said the PFS advantage was seen across different patient groups, including those with low or high PD-L1 expression and squamous or non-squamous histologies. Full results from the trial are expected at a medical event later this year. “This is an historic moment for ivonescimab, Team Summit, our partners at Akeso, and most importantly, we believe this is the beginning of a paradigm change for treatment options for patients living with cancer,” CEO Robert Duggan remarked.","kind":null,"is_publish_news":true,"is_publish_highlight":false,"is_publish_live":false,"is_publish_wemedia":null,"editions":null,"column":"","sentiment":"0","news_tag":"","news_rank":0,"symbols":[],"gpt_button":1},"commentList":[],"isCommentEnd":true,"newsSizeData":{"likeSize":0,"commentSize":0,"repostSize":0,"favoriteSize":0,"likeStatus":false,"favoriteStatus":false},"APP":{"userAgent":"Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)","isDev":false,"isTTM":true,"deviceId":"web-server-community-laohu8-v3","version":"4.27.0","shortVersion":"4.27.0","platform":"web","vendor":"web","appName":"ttm","isIOS":false,"isAndroid":false,"isTiger":false,"isTHS":false,"isWeiXin":false,"isWeiXinMini":false,"isWeiBo":false,"isQQ":false,"isBaiduSwan":false,"isBaiduBox":false,"isDingTalk":false,"isToutiao":false,"isOnePlus":false,"isHuaWei":false,"isXiaomi":false,"isXiaomiWebView":false,"isOppo":false,"isVivo":false,"isSamsung":false,"isMobile":false},"href":"/m/news/2439367487"}