Week In Review: Structure Reports Efficacy Of Obesity Drug; Raises $476M

seekingalpha06-09

Structure Therapeutics raises $476 million through an offering of its ADSs after announcing positive clinical results for its obesity drug.Suzhou Alphamab Oncology partners with ArriVent BioPharma to ...

Source Link

Disclaimer: Investing carries risk. This is not financial advice. The above content should not be regarded as an offer, recommendation, or solicitation on acquiring or disposing of any financial products, any associated discussions, comments, or posts by author or other users should not be considered as such either. It is solely for general information purpose only, which does not consider your own investment objectives, financial situations or needs. TTM assumes no responsibility or warranty for the accuracy and completeness of the information, investors should do their own research and may seek professional advice before investing.

Comments

We need your insight to fill this gap

Leave a comment

{"i18n":{"language":"en_US"},"isChannel":false,"data":{"share":"https://ttm.financial/m/news/2442853872?lang=en_US&edition=fundamental","thumbnail":"","is_english":true,"pubTime":"2024-06-09 17:15","share_image_url":"https://static.laohu8.com/5a36db9d73b4222bc376d24ccc48c8a4","id":"2442853872","market":"nz","top_or_hot":-1,"title":"Week In Review: Structure Reports Efficacy Of Obesity Drug; Raises $476M","media":"seekingalpha","content":"<div>\n<p>Structure Therapeutics raises $476 million through an offering of its ADSs after announcing positive clinical results for its obesity drug.Suzhou Alphamab Oncology partners with ArriVent BioPharma to ...</p>\n\n<a href=\"https://seekingalpha.com/article/4698228-structure-reports-efficacy-of-obesity-drug-raises-476m\">Source Link</a>\n\n</div>\n","source":"seekingalpha","html":"<!DOCTYPE html>\n<html>\n<head>\n<meta http-equiv=\"Content-Type\" content=\"text/html; charset=utf-8\" />\n<meta name=\"viewport\" content=\"width=device-width,initial-scale=1.0,minimum-scale=1.0,maximum-scale=1.0,user-scalable=no\"/>\n<meta name=\"format-detection\" content=\"telephone=no,email=no,address=no\" />\n<title>Week In Review: Structure Reports Efficacy Of Obesity Drug; Raises $476M</title>\n<style type=\"text/css\">\na,abbr,acronym,address,applet,article,aside,audio,b,big,blockquote,body,canvas,caption,center,cite,code,dd,del,details,dfn,div,dl,dt,\nem,embed,fieldset,figcaption,figure,footer,form,h1,h2,h3,h4,h5,h6,header,hgroup,html,i,iframe,img,ins,kbd,label,legend,li,mark,menu,nav,\nobject,ol,output,p,pre,q,ruby,s,samp,section,small,span,strike,strong,sub,summary,sup,table,tbody,td,tfoot,th,thead,time,tr,tt,u,ul,var,video{ font:inherit;margin:0;padding:0;vertical-align:baseline;border:0 }\nbody{ font-size:16px; line-height:1.5; color:#999; background:transparent; }\n.wrapper{ overflow:hidden;word-break:break-all;padding:10px; }\nh1,h2{ font-weight:normal; line-height:1.35; margin-bottom:.6em; }\nh3,h4,h5,h6{ line-height:1.35; margin-bottom:1em; }\nh1{ font-size:24px; }\nh2{ font-size:20px; }\nh3{ font-size:18px; }\nh4{ font-size:16px; }\nh5{ font-size:14px; }\nh6{ font-size:12px; }\np,ul,ol,blockquote,dl,table{ margin:1.2em 0; }\nul,ol{ margin-left:2em; }\nul{ list-style:disc; }\nol{ list-style:decimal; }\nli,li p{ margin:10px 0;}\nimg{ max-width:100%;display:block;margin:0 auto 1em; }\nblockquote{ color:#B5B2B1; border-left:3px solid #aaa; padding:1em; }\nstrong,b{font-weight:bold;}\nem,i{font-style:italic;}\ntable{ width:100%;border-collapse:collapse;border-spacing:1px;margin:1em 0;font-size:.9em; }\nth,td{ padding:5px;text-align:left;border:1px solid #aaa; }\nth{ font-weight:bold;background:#5d5d5d; }\n.symbol-link{font-weight:bold;}\n/* header{ border-bottom:1px solid #494756; } */\n.title{ margin:0 0 8px;line-height:1.3;color:#ddd; }\n.meta {color:#5e5c6d;font-size:13px;margin:0 0 .5em; }\na{text-decoration:none; color:#2a4b87;}\n.meta .head { display: inline-block; overflow: hidden}\n.head .h-thumb { width: 30px; height: 30px; margin: 0; padding: 0; border-radius: 50%; float: left;}\n.head .h-content { margin: 0; padding: 0 0 0 9px; float: left;}\n.head .h-name {font-size: 13px; color: #eee; margin: 0;}\n.head .h-time {font-size: 11px; color: #7E829C; margin: 0;line-height: 11px;}\n.small {font-size: 12.5px; display: inline-block; transform: scale(0.9); -webkit-transform: scale(0.9); transform-origin: left; -webkit-transform-origin: left;}\n.smaller {font-size: 12.5px; display: inline-block; transform: scale(0.8); -webkit-transform: scale(0.8); transform-origin: left; -webkit-transform-origin: left;}\n.bt-text {font-size: 12px;margin: 1.5em 0 0 0}\n.bt-text p {margin: 0}\n</style>\n</head>\n<body>\n<div class=\"wrapper\">\n<header>\n<h2 class=\"title\">\nWeek In Review: Structure Reports Efficacy Of Obesity Drug; Raises $476M\n</h2>\n\n<h4 class=\"meta\">\n\n\n2024-06-09 17:15 GMT+8&nbsp;&nbsp;&nbsp;<a href=https://seekingalpha.com/article/4698228-structure-reports-efficacy-of-obesity-drug-raises-476m><strong>seekingalpha</strong></a>\n\n\n</h4>\n\n</header>\n<article>\n<div>\n<p>Structure Therapeutics raises $476 million through an offering of its ADSs after announcing positive clinical results for its obesity drug.Suzhou Alphamab Oncology partners with ArriVent BioPharma to ...</p>\n\n<a href=\"https://seekingalpha.com/article/4698228-structure-reports-efficacy-of-obesity-drug-raises-476m\">Source Link</a>\n\n</div>\n\n\n</article>\n</div>\n</body>\n</html>\n","isBrief":false,"type":0,"news_type":1,"symbol":"BK4559","symbol_name":"巴菲特持仓","start_time":0,"source_url":"https://seekingalpha.com/article/4698228-structure-reports-efficacy-of-obesity-drug-raises-476m","article_id":"2442853872","we_media_id":null,"thumbnails":[],"rights":null,"url":"https://stock-news.laohu8.com/highlight/detail?id=2442853872","pubTimestamp":1717924500,"sourceInfo":{"source_id":"seekingalpha","name":"Seeking Alpha"},"weMediaInfo":null,"summary":"Structure Therapeutics raises $476 million through an offering of its ADSs after announcing positive clinical results for its obesity drug.Suzhou Alphamab Oncology partners with ArriVent BioPharma to ","collect":0,"end_time":0,"defaultTopTitle":"seekingalpha.com","property":[],"viewcount":null,"language":"en","relate_stocks":{"BK4559":"巴菲特持仓","LU1670711040.USD":"M&G (LUX) GLOBAL DIVIDEND \"A\" (USD) ACC","LU0456855351.SGD":"JPMorgan Funds - Global Equity A (acc) SGD","BK4535":"淡马锡持仓","BK4588":"碎股","LU2242646821.SGD":"Fidelity Global Dividend Plus A-MINCOME(G)-SGD","LU2360032135.SGD":"ALLSPRING GLOBAL EQUITY ENHANCED INCOME \"A\" (SGDHDG) INC","LU1585245621.USD":"EASTSPRING INV GLOBAL LOW VOLATILITY EQUITY FUND \"A\" (USD) ACC B","LU0237698245.USD":"富达环球地产基金A","IMAB":"天境生物","LU2125154778.USD":"ALLSPRING GLOBAL EQUITY ENHANCED INCOME \"A\" (USD) INC","IE00B2B36J28.USD":"JANUS HENDERSON GLOBAL LIFE SCIENCES \"I1\" (USD) INC","AZN":"阿斯利康","LU0321505439.SGD":"Schroder ISF Global Dividend Maximiser A Acc SGD","AKESF":"AKESO INC.","LU0321505868.SGD":"Schroder ISF Global Dividend Maximiser A Dis SGD","BK4581":"高盛持仓","IE00BSNM7G36.USD":"NEUBERGER BERMAN SYSTEMATIC GLOBAL SUSTAINABLE VALUE \"A\" (USD) ACC","ASPHF":"ASCENTAGE PHARMA GROUP","LU2125154935.USD":"ALLSPRING (LUX) WF GLOBAL EQUITY ENHANCED INCOME \"I\" (USD) INC","REGMF":"Remegen Co Ltd.","AVBP":"ArriVent BioPharma","LU1430594728.SGD":"Eastspring Investments - Global Low Volatility Equity AS SGD","GPCR":"STRUCTURE THERAPEUTICS INC SPON ADS EACH REP 3 ORD","LU1670710661.SGD":"M&G (LUX) GLOBAL DIVIDEND \"A\" (SGD) INC","LU1670710588.SGD":"M&G (LUX) GLOBAL DIVIDEND \"A\" (SGD) ACC","LU0882574055.USD":"富达全球健康医疗A ACC","LU1032466523.USD":"高盛全球多资产收益组合Acc","SMMT":"Summit Therapeutics PLC","LU2236285917.USD":"ALLIANZ GLOBAL INCOME \"AMG\" (USD) INC","LU1670711123.USD":"M&G (LUX) GLOBAL DIVIDEND \"A\" (USD) INC","LU1291159041.SGD":"CPR Invest - Global Silver Age A2 Acc SGD-H","IE0002141913.USD":"JANUS HENDERSON GLOBAL LIFE SCIENCES \"I2\" (USD) ACC","LU1074936037.SGD":"JPMorgan Funds - US Value A (acc) SGD","LU1718418525.SGD":"JPMorgan Investment Funds - Global Select Equity A (acc) SGD","SDGR":"Schrodinger Inc.","BK4505":"高瓴资本持仓","IE00BJJMRZ35.SGD":"JANUS HENDERSON GLOBAL LIFE SCIENCES \"I2\" (SGDHDG) ACC","LU2133065610.SGD":"JPMorgan Investment Funds - Global Dividend A (mth) SGD","BK4139":"生物科技","LU2242652126.USD":"FIDELITY FUNDS GLOBAL DIVIDENDS PLUS \"A\" (USD) INC","LU1571399168.USD":"ALLSPRING GLOBAL LONG/SHORT EQUITY \"IP\" (USD) ACC","BK4007":"制药","LU1829250122.USD":"高盛欧洲核心股票组合Acc","IE0009355771.USD":"骏利亨德森环球生命科技A Acc","LU0114720955.EUR":"SUSTAINABLE GLOBAL HEALTH CARE \"A\" INC","BK4526":"热门中概股","BMY":"施贵宝","BK4568":"美国抗疫概念","BK4167":"医疗保健技术"},"translate_title":"回顾一周：结构报告肥胖药物的疗效；筹集4.76亿美元","themeId":null,"isJumpTheme":false,"ttsUrl":null,"symbols_score_info":{"ASPHF":1,"SMMT":1,"SDGR":1,"REGMF":1,"IMAB":1,"GPCR":1,"BMY":1,"AKESF":1,"AVBP":1,"AZN":1},"content_text":"Structure Therapeutics raises $476 million through an offering of its ADSs after announcing positive clinical results for its obesity drug.Suzhou Alphamab Oncology partners with ArriVent BioPharma to develop antibody drug conjugates, potentially receiving up to $615.5 million in milestones.Summit Therapeutics expands its rights to Akeso's ivonescimab and raises $200 million in a private placement.TanyaJoy/iStock via Getty Images Deals and Financings Structure Therapeutics (GPCR), a San Francisco-Shanghai clinical stage company, had a busy week, announcing positive clinical results for its obesity drug and then raising $476 million via an offering of its ADSs (see story). Structure is an AI/Structure-based company that develops small molecule versions of biologic and peptides drugs. It was co-founded in 2021 by Schrödinger (SDGR), an AI company based in New York that became a strategic partner of the company previously known an ShouTi. Structure's stock price jumped from $32 per ADS before the trial news and now sits at $54 per ADS, a 65% increase. Suzhou Alphamab Oncology announced a deal with ArriVent BioPharma (AVBP), a Philadelphia area biotech, to use its linker-payload (Alphatecan) and glycan-conjugation platforms to discover antibody drug conjugates for ArriVent (see story). Alphamab will receive an unspecified upfront payment and potential milestones of up to $615.5 million, plus royalties. Jiangsu Alphamab BioPharma, an Alphamab Oncology subsidiary, will retain Greater China rights to the ADC products. Founded in 2008, Alphamab is currently advancing more than 30 active projects, including biosimilars, novel mAbs and engineered versions of mAbs and proteins. Summit Therapeutics (SMMT) of Miami expanded its rights to Akeso's (OTCPK:AKESF) ivonescimab, adding the countries in Central and South America plus the Middle East and Africa (see story). Summit signed a $70 million agreement for the expanded rights. Last week, Akeso said ivonescimab, a bispecific PD-1/VEGF antibody, showed better results than Keytruda in a Phase III trial that enrolled patients with NSCLC. As part of today's announcement, Summit also reported it raised an unsolicited $200 million in a private placement. In 2023, Summit acquired US/EU/Japan rights to ivonescimab for $500 million upfront and $4.5 billion in milestones. Company News GenScript Biotechnology may be the next target of the US Congress, as part of its ongoing examination into biopharmas with links to China. Founded in 2002 in New Jersey, GenScript offers a broad array of early biologic services to biopharmas and researchers. Its three founders are all from China, and the company has expanded into China. Two members of the US House of Representatives Committee on China asked the US intelligence community to determine if China's Chinese Communist Party influences GenScript's operations. The letter to the FBI included a strong allegation: \"GenScript is working to establish CCP-controlled chokepoints in critical areas of biotechnology in which the US currently leads,\" it said. Trials and Approvals Suzhou Ascentage Pharma (OTCPK:ASPHF) reported an objective response rate of 90.9% in a global Phase Ib/II trial of its Bcl-2 inhibitor, lisaftoclax, in Waldenström macroglobulinemia ('WM') patients who received a combination of lisaftoclax and Imbruvica, a Janssen-AbbVie BTK inhibitor. The combination was more than twice as effective than other regimens. Lisaftoclax was administered either as a monotherapy or in combination with other drugs in the trial's treatment-naïve enrollees. Lisaftoclax is the first pivotal-stage Bcl-2 inhibitor in China. The data was presented at the American Society of Clinical Oncology Annual Meeting. Nanjing Leads Biolabs presented clinical data from a Phase I/II trial of LBL-024, a bispecific antibody composed of an anti- PD-L1 and an anti-4-1BB (CD137) antibody. The candidate showed efficacy as a monotherapy for patients with advanced malignant tumors, particularly extrapulmonary neuroendocrine carcinoma (EP-NEC) patients who had failed at least one line of chemotherapy. EP-NEC is a rare disease that usually occurs in the stomach, intestines and pancreas. Because the diagnosis is usually made at a late stage of the disease, the cancer has already metastasized, and the prognosis is poor. There is no approved therapy for EP-NEC. Yantai RemeGen (OTCPK:REGMF) reported positive data from a first-in-human China Phase I/II trial of RC88, an ADC that targets mesothelin (MSLN) and delivers a monomethyl auristatin E (MMAE) payload. MSLN, a glycosylphosphatidylinositol-anchored protein, is overexpressed in several solid tumors with limited expression in normal tissues. The trial enrolled 170 patients with ovarian, non-small cell lung and cervical cancers who had previously failed other therapies. Currently, chemotherapy is the standard of care for ovarian cancer with an overall response rate of 12%, while RC88 recorded a 42% ORR in the trial. Singapore's SCG Cell Therapy Pte announced positive data from a first-in-class autologous hepatitis B virus-specific T-cell receptor-engineered T Cell therapy. In six patients with advanced HBV-HCC, SCG101 produced an objective response rate of 33%. SCG develops novel immunotherapies for infections and their associated cancers, targeting the most common cancer-causing infections: helicobacter pylori, HPV, HBV and EBV. It also develops TCR-based cellular immunotherapy products against infection- associated cancers. The trial data was included in the recent Best of EASL Congress Wrap-Up summary at the European Association for the Study of the Liver Congress in Milan, Italy. AbelZeta Pharma, a Maryland-Shanghai CAR-T company, reported positive results from a China Investigator-Initiated Trial of C-CAR031 in patients with heavily pretreated advanced hepatocellular carcinoma ('HCC'). The study showed early signs of efficacy in the patients and a manageable safety profile. C-CAR031 is an autologous, armored GPC3-targeting CAR-T therapy being developed in China, though it belongs to AstraZeneca (AZN) and is based on AstraZeneca's novel GPC3-targeting CAR-T platform. It is manufactured by AbelZeta in China, where it being co-developed by AbelZeta and AstraZeneca. I-Mab (IMAB), now a US company since selling off its China assets earlier this year, announced plans to form a clinical trial collaboration with Bristol-Myers Squibb (BMY) that will combine I-Mab's givastomig, a Claudin 18.2 x 4-1BB bispecific antibody, with BMS's PD-1, nivolumab. The Phase I trial will examine the combination as a first-line therapy for advanced Claudin 18.2-positive gastric and esophageal cancers. Patients will also receive chemotherapy (FOLFOX or CAPOX). BMW will supply nivolumab to participants in the trial. I-Mab is jointly developing givastomig with ABL Bio of Korea.  Disclosure: None.  Original Post Editor's Note: The summary bullets for this article were chosen by Seeking Alpha editors.  Editor's Note: This article discusses one or more securities that do not trade on a major U.S. exchange. Please be aware of the risks associated with these stocks.","kind":null,"is_publish_news":true,"is_publish_highlight":false,"is_publish_live":false,"is_publish_wemedia":null,"editions":null,"column":"","sentiment":"0","news_tag":"","news_rank":0,"symbols":[],"gpt_button":1},"commentList":[],"isCommentEnd":true,"newsSizeData":{"likeSize":0,"commentSize":0,"repostSize":0,"favoriteSize":0,"likeStatus":false,"favoriteStatus":false},"APP":{"userAgent":"Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)","isDev":false,"isTTM":true,"deviceId":"web-server-community-laohu8-v3","version":"4.29.1","shortVersion":"4.29.1","platform":"web","vendor":"web","appName":"ttm","isIOS":false,"isAndroid":false,"isTiger":false,"isTHS":false,"isWeiXin":false,"isWeiXinMini":false,"isWeiBo":false,"isQQ":false,"isBaiduSwan":false,"isBaiduBox":false,"isDingTalk":false,"isToutiao":false,"isOnePlus":false,"isHuaWei":false,"isXiaomi":false,"isXiaomiWebView":false,"isOppo":false,"isVivo":false,"isSamsung":false,"isMobile":false},"href":"/m/news/2442853872"}