Cartesian (RNAC) MG Study Meets Goals, Stock Down on Other Updates

Zacks07-04

Cartesian Therapeutics, Inc. RNAC announced positive top-line results from its mid-stage study evaluating lead candidate Descartes-08 in patients with generalized myasthenia gravis (MG), an autoimmune...

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RNAC announced positive top-line results from its mid-stage study evaluating lead candidate Descartes-08 in patients with generalized myasthenia gravis (MG), an autoimmune...</p>\n\n<a href=\"https://finance.yahoo.com/news/cartesian-rnac-mg-study-meets-182500875.html\">Source Link</a>\n\n</div>\n","source":"yahoofinance","html":"<!DOCTYPE html>\n<html>\n<head>\n<meta http-equiv=\"Content-Type\" content=\"text/html; charset=utf-8\" />\n<meta name=\"viewport\" content=\"width=device-width,initial-scale=1.0,minimum-scale=1.0,maximum-scale=1.0,user-scalable=no\"/>\n<meta name=\"format-detection\" content=\"telephone=no,email=no,address=no\" />\n<title>Cartesian (RNAC) MG Study Meets Goals, Stock Down on Other Updates</title>\n<style type=\"text/css\">\na,abbr,acronym,address,applet,article,aside,audio,b,big,blockquote,body,canvas,caption,center,cite,code,dd,del,details,dfn,div,dl,dt,\nem,embed,fieldset,figcaption,figure,footer,form,h1,h2,h3,h4,h5,h6,header,hgroup,html,i,iframe,img,ins,kbd,label,legend,li,mark,menu,nav,\nobject,ol,output,p,pre,q,ruby,s,samp,section,small,span,strike,strong,sub,summary,sup,table,tbody,td,tfoot,th,thead,time,tr,tt,u,ul,var,video{ font:inherit;margin:0;padding:0;vertical-align:baseline;border:0 }\nbody{ font-size:16px; line-height:1.5; color:#999; background:transparent; }\n.wrapper{ overflow:hidden;word-break:break-all;padding:10px; }\nh1,h2{ font-weight:normal; line-height:1.35; margin-bottom:.6em; }\nh3,h4,h5,h6{ line-height:1.35; margin-bottom:1em; }\nh1{ font-size:24px; }\nh2{ font-size:20px; }\nh3{ font-size:18px; }\nh4{ font-size:16px; }\nh5{ font-size:14px; }\nh6{ font-size:12px; }\np,ul,ol,blockquote,dl,table{ margin:1.2em 0; }\nul,ol{ margin-left:2em; }\nul{ list-style:disc; }\nol{ list-style:decimal; }\nli,li p{ margin:10px 0;}\nimg{ max-width:100%;display:block;margin:0 auto 1em; }\nblockquote{ color:#B5B2B1; border-left:3px solid #aaa; padding:1em; }\nstrong,b{font-weight:bold;}\nem,i{font-style:italic;}\ntable{ width:100%;border-collapse:collapse;border-spacing:1px;margin:1em 0;font-size:.9em; }\nth,td{ padding:5px;text-align:left;border:1px solid #aaa; }\nth{ font-weight:bold;background:#5d5d5d; }\n.symbol-link{font-weight:bold;}\n/* header{ border-bottom:1px solid #494756; } */\n.title{ margin:0 0 8px;line-height:1.3;color:#ddd; }\n.meta {color:#5e5c6d;font-size:13px;margin:0 0 .5em; }\na{text-decoration:none; color:#2a4b87;}\n.meta .head { display: inline-block; overflow: hidden}\n.head .h-thumb { width: 30px; height: 30px; margin: 0; padding: 0; border-radius: 50%; float: left;}\n.head .h-content { margin: 0; padding: 0 0 0 9px; float: left;}\n.head .h-name {font-size: 13px; color: #eee; margin: 0;}\n.head .h-time {font-size: 11px; color: #7E829C; margin: 0;line-height: 11px;}\n.small {font-size: 12.5px; display: inline-block; transform: scale(0.9); -webkit-transform: scale(0.9); transform-origin: left; -webkit-transform-origin: left;}\n.smaller {font-size: 12.5px; display: inline-block; transform: scale(0.8); -webkit-transform: scale(0.8); transform-origin: left; -webkit-transform-origin: left;}\n.bt-text {font-size: 12px;margin: 1.5em 0 0 0}\n.bt-text p {margin: 0}\n</style>\n</head>\n<body>\n<div class=\"wrapper\">\n<header>\n<h2 class=\"title\">\nCartesian (RNAC) MG Study Meets Goals, Stock Down on Other Updates\n</h2>\n\n<h4 class=\"meta\">\n\n\n2024-07-04 02:25 GMT+8&nbsp;&nbsp;&nbsp;<a href=https://finance.yahoo.com/news/cartesian-rnac-mg-study-meets-182500875.html><strong>Zacks</strong></a>\n\n\n</h4>\n\n</header>\n<article>\n<div>\n<p>Cartesian Therapeutics, Inc. RNAC announced positive top-line results from its mid-stage study evaluating lead candidate Descartes-08 in patients with generalized myasthenia gravis (MG), an autoimmune...</p>\n\n<a href=\"https://finance.yahoo.com/news/cartesian-rnac-mg-study-meets-182500875.html\">Source Link</a>\n\n</div>\n\n\n</article>\n</div>\n</body>\n</html>\n","isBrief":false,"type":0,"news_type":1,"symbol":null,"symbol_name":null,"start_time":0,"source_url":"https://finance.yahoo.com/news/cartesian-rnac-mg-study-meets-182500875.html","article_id":"2448379894","we_media_id":null,"thumbnails":["https://s.yimg.com/uu/api/res/1.2/H9DYdttPy00EKBHhcxtlCA--~B/aD00MDA7dz02MzU7YXBwaWQ9eXRhY2h5b24-/https://media.zenfs.com/en/zacks.com/9f2a2e04a053cda7a8c096e532e43d28"],"rights":null,"url":"https://stock-news.laohu8.com/highlight/detail?id=2448379894","pubTimestamp":1720031100,"sourceInfo":{"source_id":"yahoofinance","name":"雅虎金融"},"weMediaInfo":null,"summary":"Cartesian Therapeutics, Inc. RNAC announced positive top-line results from its mid-stage study evaluating lead candidate Descartes-08 in patients with generalized myasthenia gravis , an autoimmune disease associated with muscle weakness.A total of 36 heavily pre-treated, highly symptomatic MG patients were randomized equally to receive either Descartes-08 or placebo, administered as six weekly outpatient infusions without preconditioning chemotherapy in this phase IIb double-blind, placebo-controlled, crossover study. Patients receiving placebo were eligible to cross over to Descartes-08 treatment at the conclusion of the trial’s blinded follow-up assessment after three months.Descartes-08 is an autologous mRNA-engineered chimeric antigen receptor T-cell therapy  directed against the B cell maturation antigen.mRNA CAR-T administration does not require preconditioning chemotherapy, can be administered in the outpatient setting, and does not carry the risk of genomic integration associat","collect":0,"end_time":0,"defaultTopTitle":"yahoo.com","property":[],"viewcount":null,"language":"en","relate_stocks":{},"translate_title":"笛卡尔(RNAC)MG研究达到目标，其他更新库存下降","themeId":null,"isJumpTheme":false,"ttsUrl":null,"symbols_score_info":{"ARGX":1,"MG":1,"MGC":1,"NERV":1,"RNAC":1,"SLE":1,"ALXO":0.9},"content_text":"Cartesian Therapeutics, Inc. RNAC announced positive top-line results from its mid-stage study evaluating lead candidate Descartes-08 in patients with generalized myasthenia gravis (MG), an autoimmune disease associated with muscle weakness.\nA total of 36 heavily pre-treated, highly symptomatic MG patients were randomized equally to receive either Descartes-08 or placebo, administered as six weekly outpatient infusions without preconditioning chemotherapy in this phase IIb double-blind, placebo-controlled, crossover study. Patients receiving placebo were eligible to cross over to Descartes-08 treatment at the conclusion of the trial’s blinded follow-up assessment after three months.\nDescartes-08 is an autologous mRNA-engineered chimeric antigen receptor T-cell therapy (mRNA CAR-T) directed against the B cell maturation antigen.\nmRNA CAR-T administration does not require preconditioning chemotherapy, can be administered in the outpatient setting, and does not carry the risk of genomic integration associated with cancerous transformation unlike conventional DNA-based CAR T-cell therapies.\nThe study achieved its primary endpoint with statistical significance in the pre-specified modified intent-to-treat efficacy population. Results showed 71% of MG patients treated with Descartes-08 had 5-point or greater improvements in MG Composite (MGC) score at month three compared to only 25% treated with placebo.\nThe study also achieved its primary endpoint with statistical significance in the per-protocol population. 69% of patients treated with Descartes-08 had 5-point or greater improvements in MGC score at month three compared to 33% treated with placebo.\nMoreover, Descartes-08 responders experienced deep improvements across the MG severity scales at month three. These improvements persisted or further improved in patients who were evaluated after four and six months follow-up visits, as of the cutoff date of Jun 19, 2024. The results were also consistent with the previously reported results from the phase IIa open-label portion of the trial.\nThe safety profile of the candidate continues to support outpatient administration.\nConcurrently, Cartesian announced positive updated results from two patients enrolled in the phase IIa open-label portion of the trial. Both retreated patients experienced rapid improvement in clinical scores and maintained minimal symptom expression for up to one year after receiving a second treatment cycle.\nCartesian expects to hold an end-of-phase II meeting with the FDA by year-end. The candidate was previously granted Regenerative Medicine Advanced Therapy Designation and Orphan Drug Designation by the FDA for the treatment of MG.\nDescartes-08 is also being evaluated for systematic lupus erythematosus (SLE). Cartesian also announced the dosing of the first patient in its mid-stage open-label study evaluating Descartes-08 in patients with SLE.\nThe phase II open-label study is likely to enroll up to 30 adult patients. The study is designed to evaluate the safety and tolerability of outpatient administration of Descartes-08 without preconditioning chemotherapy for the treatment of patients with moderate or severe SLE refractory to immunosuppressant therapy. Secondary outcome measures will assess overall disease activity.\nShares of Cartesian have lost 23.8% year to date compared with the industry’s decline of 6.3%.\nImage Source: Zacks Investment Research\nDespite the positive results from the MG study, shares of RNAC plunged 35% on Jul 2.\nThis can likely be attributed to the company’s announcement of a $130-million private placement equity financing through the sale of shares priced at $20 each.\nThe net proceeds from this financing, together with the existing cash, cash equivalents, and marketable securities, should enable the company to fund its pipeline programs for Descartes-08 and general corporate purposes and working capital.\nNonetheless, the successful development of Descartes-08 for MG should be a significant boost for the company.\nargenx’ ARGX Vyvgart Hytrulo is currently approved in the United States for the treatment of GMG in adult patients who are anti-acetylcholine receptor antibody positive.\nARGX recently won an FDA nod for a second indication for Vyvgart Hytrulo, chronic inflammatory demyelinating polyneuropathy.\nZacks Rank & Stocks to Consider\nCartesian currently carries a Zacks Rank #3 (Hold).\nA couple of better-ranked stocks in the biotech sector are ALX Oncology Holdings ALXO and Minerva Neurosciences, Inc. NERV, both carrying a Zacks Rank #2 (Buy) at present. You can see the complete list of today’s Zacks #1 Rank (Strong Buy) stocks here.\nIn the past 30 days, the Zacks Consensus Estimate for ALX Oncology’s 2024 loss per share has narrowed from $3.33 to $2.89. During the same period, the consensus estimate for 2025 loss per share has narrowed from $2.85 to $2.73.\nALX Oncology beat on earnings in two of the trailing four quarters and missed the mark in the other two, delivering an average negative surprise of 8.83%.\nIn the past 90 days, estimates for Minerva Neurosciences’ 2024 loss per share have narrowed from $3.57 to $1.89. The loss per share estimate for 2025 has narrowed from $4.54 to $3.60.\nNERV’s earnings beat estimates in one of the trailing four quarters and missed the same in the other three, the average negative surprise being 54.43%. \nWant the latest recommendations from Zacks Investment Research? Today, you can download 7 Best Stocks for the Next 30 Days. Click to get this free report\nMinerva Neurosciences, Inc (NERV) : Free Stock Analysis Report\nargenex SE (ARGX) : Free Stock Analysis Report\nALX Oncology Holdings Inc. (ALXO) : Free Stock Analysis Report\nCartesian Therapeutics, Inc. (RNAC) : Free Stock Analysis Report\nTo read this article on Zacks.com click here.\nZacks Investment Research","kind":"highlight","is_publish_news":true,"is_publish_highlight":false,"is_publish_live":false,"is_publish_wemedia":null,"editions":null,"column":"","sentiment":"0","news_tag":"","news_rank":0,"symbols":[],"gpt_button":1},"commentList":[],"isCommentEnd":true,"newsSizeData":{"likeSize":0,"commentSize":0,"repostSize":0,"favoriteSize":0,"likeStatus":false,"favoriteStatus":false},"APP":{"userAgent":"Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)","isDev":false,"isTTM":true,"deviceId":"web-server-community-laohu8-v3","version":"4.29.3","shortVersion":"4.29.3","platform":"web","vendor":"web","appName":"ttm","isIOS":false,"isAndroid":false,"isTiger":false,"isTHS":false,"isWeiXin":false,"isWeiXinMini":false,"isWeiBo":false,"isQQ":false,"isBaiduSwan":false,"isBaiduBox":false,"isDingTalk":false,"isToutiao":false,"isOnePlus":false,"isHuaWei":false,"isXiaomi":false,"isXiaomiWebView":false,"isOppo":false,"isVivo":false,"isSamsung":false,"isMobile":false},"href":"/m/news/2448379894"}