NRBO: Positive SAD Part 1 Data; MAD Part 2 Results Expected in 1Q25…

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By David Bautz, PhD NASDAQ:NRBO READ THE FULL NRBO RESEARCH REPORT On September 30, 2024, NeuroBo Pharmaceuticals, Inc. (NASDAQ:NRBO) announced positive topline results for the single ascending dose ...

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(NASDAQ:NRBO) announced positive topline results for the single ascending dose ...</p>\n\n<a href=\"https://finance.yahoo.com/news/nrbo-positive-sad-part-1-133000495.html\">Source Link</a>\n\n</div>\n","source":"yahoofinance","html":"<!DOCTYPE html>\n<html>\n<head>\n<meta http-equiv=\"Content-Type\" content=\"text/html; charset=utf-8\" />\n<meta name=\"viewport\" content=\"width=device-width,initial-scale=1.0,minimum-scale=1.0,maximum-scale=1.0,user-scalable=no\"/>\n<meta name=\"format-detection\" content=\"telephone=no,email=no,address=no\" />\n<title>NRBO: Positive SAD Part 1 Data; MAD Part 2 Results Expected in 1Q25…</title>\n<style type=\"text/css\">\na,abbr,acronym,address,applet,article,aside,audio,b,big,blockquote,body,canvas,caption,center,cite,code,dd,del,details,dfn,div,dl,dt,\nem,embed,fieldset,figcaption,figure,footer,form,h1,h2,h3,h4,h5,h6,header,hgroup,html,i,iframe,img,ins,kbd,label,legend,li,mark,menu,nav,\nobject,ol,output,p,pre,q,ruby,s,samp,section,small,span,strike,strong,sub,summary,sup,table,tbody,td,tfoot,th,thead,time,tr,tt,u,ul,var,video{ font:inherit;margin:0;padding:0;vertical-align:baseline;border:0 }\nbody{ font-size:16px; line-height:1.5; color:#999; background:transparent; }\n.wrapper{ overflow:hidden;word-break:break-all;padding:10px; }\nh1,h2{ font-weight:normal; line-height:1.35; margin-bottom:.6em; }\nh3,h4,h5,h6{ line-height:1.35; margin-bottom:1em; }\nh1{ font-size:24px; }\nh2{ font-size:20px; }\nh3{ font-size:18px; }\nh4{ font-size:16px; }\nh5{ font-size:14px; }\nh6{ font-size:12px; }\np,ul,ol,blockquote,dl,table{ margin:1.2em 0; }\nul,ol{ margin-left:2em; }\nul{ list-style:disc; }\nol{ list-style:decimal; }\nli,li p{ margin:10px 0;}\nimg{ max-width:100%;display:block;margin:0 auto 1em; }\nblockquote{ color:#B5B2B1; border-left:3px solid #aaa; padding:1em; }\nstrong,b{font-weight:bold;}\nem,i{font-style:italic;}\ntable{ width:100%;border-collapse:collapse;border-spacing:1px;margin:1em 0;font-size:.9em; }\nth,td{ padding:5px;text-align:left;border:1px solid #aaa; }\nth{ font-weight:bold;background:#5d5d5d; }\n.symbol-link{font-weight:bold;}\n/* header{ border-bottom:1px solid #494756; } */\n.title{ margin:0 0 8px;line-height:1.3;color:#ddd; }\n.meta {color:#5e5c6d;font-size:13px;margin:0 0 .5em; }\na{text-decoration:none; color:#2a4b87;}\n.meta .head { display: inline-block; overflow: hidden}\n.head .h-thumb { width: 30px; height: 30px; margin: 0; padding: 0; border-radius: 50%; float: left;}\n.head .h-content { margin: 0; padding: 0 0 0 9px; float: left;}\n.head .h-name {font-size: 13px; color: #eee; margin: 0;}\n.head .h-time {font-size: 11px; color: #7E829C; margin: 0;line-height: 11px;}\n.small {font-size: 12.5px; display: inline-block; transform: scale(0.9); -webkit-transform: scale(0.9); transform-origin: left; -webkit-transform-origin: left;}\n.smaller {font-size: 12.5px; display: inline-block; transform: scale(0.8); -webkit-transform: scale(0.8); transform-origin: left; -webkit-transform-origin: left;}\n.bt-text {font-size: 12px;margin: 1.5em 0 0 0}\n.bt-text p {margin: 0}\n</style>\n</head>\n<body>\n<div class=\"wrapper\">\n<header>\n<h2 class=\"title\">\nNRBO: Positive SAD Part 1 Data; MAD Part 2 Results Expected in 1Q25…\n</h2>\n\n<h4 class=\"meta\">\n\n\n2024-10-01 21:30 GMT+8&nbsp;&nbsp;&nbsp;<a href=https://finance.yahoo.com/news/nrbo-positive-sad-part-1-133000495.html><strong>Zacks Small Cap Research</strong></a>\n\n\n</h4>\n\n</header>\n<article>\n<div>\n<p>By David Bautz, PhD\n NASDAQ:NRBO\nREAD THE FULL NRBO RESEARCH REPORT\nOn September 30, 2024, NeuroBo Pharmaceuticals, Inc. (NASDAQ:NRBO) announced positive topline results for the single ascending dose ...</p>\n\n<a href=\"https://finance.yahoo.com/news/nrbo-positive-sad-part-1-133000495.html\">Source Link</a>\n\n</div>\n\n\n</article>\n</div>\n</body>\n</html>\n","isBrief":false,"type":0,"news_type":1,"symbol":"BK4218","symbol_name":"酒店及度假村房地产信托","start_time":0,"source_url":"https://finance.yahoo.com/news/nrbo-positive-sad-part-1-133000495.html","article_id":"2472307012","we_media_id":null,"thumbnails":["https://s.yimg.com/uu/api/res/1.2/RRSNJfSPx2PAmdImCIrE3g--~B/aD0xMDI4O3c9MTc0MjthcHBpZD15dGFjaHlvbg--/https://media.zenfs.com/en/scr.zacks.com/023816fda1d0fb3f28872c65452b27eb"],"rights":null,"url":"https://stock-news.laohu8.com/highlight/detail?id=2472307012","pubTimestamp":1727789400,"sourceInfo":{"source_id":"yahoofinance","name":"雅虎金融"},"weMediaInfo":null,"summary":"On September 30, 2024, NeuroBo Pharmaceuticals, Inc.  announced positive topline results for the single ascending dose  Part 1 of the ongoing Phase 1 clinical trial of DA-1726 for the treatment of obesity. A total of 45 obese but otherwise healthy individuals were randomized in a double blind, 6:3 ratio to receive DA-1726 or placebo. The results showed that DA-1726 was safe, well tolerated, and had linear pharmacokinetics . In regards to safety, only five subjects in the DA-1726 group reported adverse events  compared to three subjects in the placebo group. Due to the strong safety profile, at least one additional dosing cohort is being added to evaluate the maximum tolerated dose.The multiple ascending dose  Part 2 of the trial is ongoing, with the first patient enrolled in June 2024. A total of 36 individuals are expected to be enrolled in Part 2 of the trial in a 6:3 ratio across four dosing cohorts. Each participant will receive four weekly administrations of DA-1726 or placebo. To","collect":0,"end_time":0,"defaultTopTitle":"yahoo.com","property":[],"viewcount":null,"language":"en","relate_stocks":{"BK4218":"酒店及度假村房地产信托","BK4139":"生物科技","BK4181":"酒店及度假村房地产投资信托","NRBO":"NeuroBo Pharmaceuticals, Inc.","PK":"Park Hotels & Resorts Inc."},"translate_title":"NRBO：阳性SAD第1部分数据；MAD第2部分结果预计将于25年第一季度公布……","themeId":null,"isJumpTheme":false,"ttsUrl":null,"symbols_score_info":{"NRBO":1,"PK":1},"content_text":"By David Bautz, PhD\n NASDAQ:NRBO\nREAD THE FULL NRBO RESEARCH REPORT\nOn September 30, 2024, NeuroBo Pharmaceuticals, Inc. (NASDAQ:NRBO) announced positive topline results for the single ascending dose (SAD) Part 1 of the ongoing Phase 1 clinical trial of DA-1726 for the treatment of obesity. A total of 45 obese but otherwise healthy individuals were randomized in a double blind, 6:3 ratio to receive DA-1726 or placebo. The results showed that DA-1726 was safe, well tolerated, and had linear pharmacokinetics (PK). In regards to safety, only five subjects in the DA-1726 group reported adverse events (AEs) compared to three subjects in the placebo group. Due to the strong safety profile, at least one additional dosing cohort is being added to evaluate the maximum tolerated dose. \nThe multiple ascending dose (MAD) Part 2 of the trial is ongoing, with the first patient enrolled in June 2024. A total of 36 individuals are expected to be enrolled in Part 2 of the trial in a 6:3 ratio across four dosing cohorts. Each participant will receive four weekly administrations of DA-1726 or placebo. Topline results from Part 2 are expected in the first quarter of 2025. \nThe company continues planning for Part 3 of the trial, which we anticipate initiating in the third quarter of 2025, with an interim data readout in mid-2026 and topline results being reported in the second half of 2026. The following slide provides an overview of Part 3 of the trial, which will evaluate early proof of concept and maximum titratable dose of DA-1726.\n\nConclusion\nAs expected, the results from the SAD Part 1 of the Phase 1 trial of DA-1726 showed that the drug is well tolerated and exhibits linear PK. The fact that the company will be adding at least one additional dosing cohort is very good news as it looks to find the maximum tolerated dose. Tolerability is a key differentiating factor amongst the many obesity therapies in development, with many having been discontinued due to a high level of AEs. Thus, a highly tolerable drug could warrant considerable interest from potential commercialization partners. We look forward to the MAD results in the first quarter of 2025 as the company moves toward the initiation of Part 3 of the trial in the third quarter of 2025. With no changes to our model our valuation remains at $22 per share. \nSUBSCRIBE TO ZACKS SMALL CAP RESEARCH to receive our articles and reports emailed directly to you each morning. Please visit our website for additional information on Zacks SCR. \n \nDISCLOSURE: Zacks SCR has received compensation from the issuer directly, from an investment manager, or from an investor relations consulting firm, engaged by the issuer, for providing research coverage for a period of no less than one year. Research articles, as seen here, are part of the service Zacks SCR provides and Zacks SCR receives quarterly payments totaling a maximum fee of up to $40,000 annually for these services provided to or regarding the issuer. 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