Kiora Pharmaceuticals Reports Third Quarter Results; Retinal Disease Pipeline Advancing Two Phase 2 Studies

Newsfile2024-11-08

Encinitas, California--(Newsfile Corp. - November 8, 2024) - Kiora Pharmaceuticals, Inc. (NASDAQ: KPRX) ("Kiora" or the "Company") today announced third quarter 2024 financial results and provided an ...

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(NASDAQ: KPRX) (\"Kiora\" or the \"Company\") today announced third quarter 2024 financial results and provided an ...</p>\n\n<a href=\"https://finance.yahoo.com/news/kiora-pharmaceuticals-reports-third-quarter-120000099.html\">Source Link</a>\n\n</div>\n","source":"yahoofinance","html":"<!DOCTYPE html>\n<html>\n<head>\n<meta http-equiv=\"Content-Type\" content=\"text/html; charset=utf-8\" />\n<meta name=\"viewport\" content=\"width=device-width,initial-scale=1.0,minimum-scale=1.0,maximum-scale=1.0,user-scalable=no\"/>\n<meta name=\"format-detection\" content=\"telephone=no,email=no,address=no\" />\n<title>Kiora Pharmaceuticals Reports Third Quarter Results; Retinal Disease Pipeline Advancing Two Phase 2 Studies</title>\n<style type=\"text/css\">\na,abbr,acronym,address,applet,article,aside,audio,b,big,blockquote,body,canvas,caption,center,cite,code,dd,del,details,dfn,div,dl,dt,\nem,embed,fieldset,figcaption,figure,footer,form,h1,h2,h3,h4,h5,h6,header,hgroup,html,i,iframe,img,ins,kbd,label,legend,li,mark,menu,nav,\nobject,ol,output,p,pre,q,ruby,s,samp,section,small,span,strike,strong,sub,summary,sup,table,tbody,td,tfoot,th,thead,time,tr,tt,u,ul,var,video{ font:inherit;margin:0;padding:0;vertical-align:baseline;border:0 }\nbody{ font-size:16px; line-height:1.5; color:#999; background:transparent; }\n.wrapper{ overflow:hidden;word-break:break-all;padding:10px; }\nh1,h2{ font-weight:normal; line-height:1.35; margin-bottom:.6em; }\nh3,h4,h5,h6{ line-height:1.35; margin-bottom:1em; }\nh1{ font-size:24px; }\nh2{ font-size:20px; }\nh3{ font-size:18px; }\nh4{ font-size:16px; }\nh5{ font-size:14px; }\nh6{ font-size:12px; }\np,ul,ol,blockquote,dl,table{ margin:1.2em 0; }\nul,ol{ margin-left:2em; }\nul{ list-style:disc; }\nol{ list-style:decimal; }\nli,li p{ margin:10px 0;}\nimg{ max-width:100%;display:block;margin:0 auto 1em; }\nblockquote{ color:#B5B2B1; border-left:3px solid #aaa; padding:1em; }\nstrong,b{font-weight:bold;}\nem,i{font-style:italic;}\ntable{ width:100%;border-collapse:collapse;border-spacing:1px;margin:1em 0;font-size:.9em; }\nth,td{ padding:5px;text-align:left;border:1px solid #aaa; }\nth{ font-weight:bold;background:#5d5d5d; }\n.symbol-link{font-weight:bold;}\n/* header{ border-bottom:1px solid #494756; } */\n.title{ margin:0 0 8px;line-height:1.3;color:#ddd; }\n.meta {color:#5e5c6d;font-size:13px;margin:0 0 .5em; }\na{text-decoration:none; color:#2a4b87;}\n.meta .head { display: inline-block; overflow: hidden}\n.head .h-thumb { width: 30px; height: 30px; margin: 0; padding: 0; border-radius: 50%; float: left;}\n.head .h-content { margin: 0; padding: 0 0 0 9px; float: left;}\n.head .h-name {font-size: 13px; color: #eee; margin: 0;}\n.head .h-time {font-size: 11px; color: #7E829C; margin: 0;line-height: 11px;}\n.small {font-size: 12.5px; display: inline-block; transform: scale(0.9); -webkit-transform: scale(0.9); transform-origin: left; -webkit-transform-origin: left;}\n.smaller {font-size: 12.5px; display: inline-block; transform: scale(0.8); -webkit-transform: scale(0.8); transform-origin: left; -webkit-transform-origin: left;}\n.bt-text {font-size: 12px;margin: 1.5em 0 0 0}\n.bt-text p {margin: 0}\n</style>\n</head>\n<body>\n<div class=\"wrapper\">\n<header>\n<h2 class=\"title\">\nKiora Pharmaceuticals Reports Third Quarter Results; Retinal Disease Pipeline Advancing Two Phase 2 Studies\n</h2>\n\n<h4 class=\"meta\">\n\n\n2024-11-08 20:00 GMT+8&nbsp;&nbsp;&nbsp;<a href=https://finance.yahoo.com/news/kiora-pharmaceuticals-reports-third-quarter-120000099.html><strong>Newsfile</strong></a>\n\n\n</h4>\n\n</header>\n<article>\n<div>\n<p>Encinitas, California--(Newsfile Corp. - November 8, 2024) - Kiora Pharmaceuticals, Inc. (NASDAQ: KPRX) (\"Kiora\" or the \"Company\") today announced third quarter 2024 financial results and provided an ...</p>\n\n<a href=\"https://finance.yahoo.com/news/kiora-pharmaceuticals-reports-third-quarter-120000099.html\">Source Link</a>\n\n</div>\n\n\n</article>\n</div>\n</body>\n</html>\n","isBrief":false,"type":0,"news_type":1,"symbol":"BK4007","symbol_name":"制药","start_time":0,"source_url":"https://finance.yahoo.com/news/kiora-pharmaceuticals-reports-third-quarter-120000099.html","article_id":"2481760301","we_media_id":null,"thumbnails":["https://s.yimg.com/uu/api/res/1.2/yslxOAdknIhWYTDPYWloTQ--~B/aD00MDA7dz00MDA7YXBwaWQ9eXRhY2h5b24-/https://media.zenfs.com/en/newsfile_64/efa0f6624c36b9d07ddf3f37492ecea5"],"rights":{"source":"yahoofinance","url":"https://finance.yahoo.com/news/kiora-pharmaceuticals-reports-third-quarter-120000099.html","rn_cache_url":null,"customStyle":"img, svg { display: none !important; }","selectors":"article","filters":"","directOrigin":true},"url":"https://stock-news.laohu8.com/highlight/detail?id=2481760301","pubTimestamp":1731067200,"columns":[],"sourceInfo":{"source_id":"yahoofinance","name":"雅虎金融"},"weMediaInfo":null,"summary":"Encinitas, California-- - Kiora Pharmaceuticals, Inc.   today announced third quarter 2024 financial results and provided an update on its pipeline of therapeutics for the treatment of retinal diseases. Key third quarter and recent corporate highlights include:. Investigational new drug application approval to initiate ABACUS-2, the Phase 2 study of KIO-301, a novel molecular photoswitch, for the treatment of retinitis pigmentosa.\"Our other active program is KIO-104, a potent, locally delivered small molecule that we are developing to treat inflammatory retinal diseases. The goal is to offer patients and providers an alternative to chronic steroid use or systemic anti-inflammatory drugs, both of which often lead to complications. KIO-104 acts by suppressing specific types","collect":0,"end_time":0,"defaultTopTitle":"yahoo.com","property":[],"viewcount":null,"language":"en","relate_stocks":{"BK4007":"制药","KPRX":"Kiora Pharmaceuticals","WRD":"文远知行"},"translate_title":"Kiora Pharmaceuticals公布第三季度业绩；视网膜疾病管道推进两项2期研究","themeId":null,"isJumpTheme":false,"ttsUrl":null,"symbols_score_info":{"KPRX":1,"WRD":1},"content_text":"Encinitas, California--(Newsfile Corp. - November 8, 2024) - Kiora Pharmaceuticals, Inc. (NASDAQ: KPRX) (\"Kiora\" or the \"Company\") today announced third quarter 2024 financial results and provided an update on its pipeline of therapeutics for the treatment of retinal diseases. Key third quarter and recent corporate highlights include: \n\nInvestigational new drug application approval to initiate ABACUS-2, the Phase 2 study of KIO-301, a novel molecular photoswitch, for the treatment of retinitis pigmentosa.\nFinalized the design of the Phase 2 KLARITY trial of KIO-104, a small molecule targeting the treatment of multiple retinal inflammatory diseases, with submission for trial approval on track for Q4 2024. \nEnded the quarter with $29.0 million in cash, cash equivalents and short-term investments plus $1.8 million in collaboration receivables related to the Company's Théa Open Innovation (TOI or Théa) partnership.\nExpected runway into 2027, excluding any potential partnership milestones.\n\n\"Kiora remains in a strong position with two compelling and innovative drug candidates entering Phase 2 clinical trials and a strong balance sheet to fund development and operations beyond anticipated readouts for both studies,\" said Brian M. Strem, Ph.D., President & Chief Executive Officer of Kiora. \"During the third quarter, we worked diligently to prepare for these trials, which will increase their likelihood of success. \n\"Regarding KIO-301, we recently received approval to initiate ABACUS-2, a 36-patient, multi-center, double-masked, randomized, controlled, multi-dose study in patients with ultra-low vision or no light perception due to retinitis pigmentosa. Based on KIO-301's differentiated mechanism of action as a small molecule, we will enroll patients with any of the known 150-plus underlying gene mutations associated with retinitis pigmentosa. Dosing of the first patient with KIO-301 will begin next year following the completion of the ongoing validation work around functional vision endpoints. \n\"Following multiple interactions with the FDA and European regulators, retinal specialists, and patient advocacy groups, it's clear that demonstrating improvement in functional vision is essential for marketing authorization as well as reimbursement. Thus, throughout the third quarter and continuing into the fourth, we've invested time to validate functional vision endpoints, increasing the probability of success of ABACUS-2 and a potential Phase 3 study in the US and Europe. This validation work is being performed in collaboration with our partner Théa, with additional support from the Choroideremia Research Foundation. \n\"Our other active program is KIO-104, a potent, locally delivered small molecule that we are developing to treat inflammatory retinal diseases. The goal is to offer patients and providers an alternative to chronic steroid use or systemic anti-inflammatory drugs, both of which often lead to complications. KIO-104 acts by suppressing specific types of T cells and their resulting biomolecules (cytokines) that underlie damaging inflammation. Following a previously successful first-in-man study, we now plan to initiate KLARITY in the first half of next year. This study will be a Phase 2 clinical trial to explore multiple doses of KIO-104 in patients with inflammatory retinal diseases, including posterior non-infectious uveitis and diabetic macular edema. Findings in the study will inform a dose expansion trial in one or more specific indications.\" \nKiora's Chief Financial Officer, Melissa Tosca, added, \"We continue to efficiently manage our cash while creating value by investing in our pipeline. Our Théa partnership enables our overall pipeline progress through their reimbursement of our KIO-301 R&D activities, allowing us to invest further in KIO-104. Going forward, we anticipate R&D expenses will increase as we begin patient enrollment in the KLARITY trial. However, we maintain a cash runway into 2027, before any potential partnership milestones, and beyond the expected data readouts from ABACUS-2 and KLARITY.\"\nThird Quarter Financial Highlights \nKiora ended the third quarter of 2024 with $29.0 million in cash and cash equivalents and short-term investments. In addition, the Company recorded $1.8 million in collaboration receivables from TOI for reimbursed R&D expenses and $0.4 million R&D incentive tax credits. The increase in cash position from the prior quarter was due primarily to the receipt of $1.5 million in R&D incentive tax credits. \nResearch and development expenses for the third quarter of 2024 were $2.2 million, before recognizing $0.9 million in reimbursement from Théa. This resulted in net research and development expenses for the third quarter of 2024 of $1.3 million compared to $1.1 million in R&D expenses in the third quarter of 2023, during which time there were no partnership-related reimbursement credits. The year-over-year increase was primarily due to research activities related to KIO-301 and KIO-104. \nGeneral and administrative expenses were $1.4 million for the third quarter of 2024, no change from the $1.4 million spent in the third quarter of 2023. \nNet loss was $3.4 million for the third quarter of 2024 compared to a net loss of $5.8 million for the third quarter of 2023. The decrease in net loss is primarily attributed to a non-cash component, the change in fair value of contingent consideration, of -$1.1 million in the third quarter of 2024 related to the strategic decision to focus on KIO-301 and KIO-104 and halt any continuing development and licensing activities for KIO-201. \nAbout Kiora Pharmaceuticals\nKiora Pharmaceuticals is a clinical-stage biotechnology company developing and commercializing products for the treatment of orphan retinal diseases. KIO-301 is being developed for the treatment of retinitis pigmentosa, choroideremia, and Stargardt disease. It is a molecular photoswitch that has the potential to restore vision in patients with inherited and/or age-related retinal degeneration. KIO-104 is being developed for the treatment of retinal inflammation. It is a next-generation, non-steroidal, immuno-modulatory, and small-molecule inhibitor of dihydroorotate dehydrogenase. In addition to news releases and SEC filings, we expect to post information on our website, www.kiorapharma.com, and social media accounts that could be relevant to investors. We encourage investors to follow us on Twitter and LinkedIn as well as to visit our website and/or subscribe to email alerts.\nForward-Looking Statements\nSome of the statements in this press release are \"forward-looking\" and are made pursuant to the safe harbor provision of the Private Securities Litigation Reform Act of 1995. These \"forward-looking\" statements include statements relating to, among other things, Kiora's ability to execute on development and commercialization efforts and other regulatory or marketing approval efforts pertaining to Kiora's development-stage products, including KIO-104 and KIO-301, as well as the success thereof, with such approvals or success may not be obtained or achieved on a timely basis or at all, the sufficiency of existing cash on hand to fund operations for specific periods, the projected cash runway, the ability to timely complete planned initiatives for 2024, including phase 2 clinical development of KIO-301 and KIO-104, the potential for KIO-301 to be the first treatment options for patients with inherited degenerative diseases like RP, Kiora's plans to further fund development of KIO-104, the potential for KIO-104 to reduce inflammation, the timing of topline results from clinical trials of KIO-104, the potential for KIO-104 to apply to other retinal inflammatory diseases, the anticipated readout dates for Kiora's clinical trials and their likelihood of success, and expected trends for research and development and general and administrative spending in 2024. These statements involve risks and uncertainties that may cause results to differ materially from the statements set forth in this press release the ability to conduct clinical trials on a timely basis, market and other conditions and certain risk factors described under the heading \"Risk Factors\" contained in Kiora's Annual Report on Form 10-K filed with the SEC on March 25, 2024 or described in Kiora's other public filings including on Form 10-Q filed with the SEC on November 8, 2024. Kiora's results may also be affected by factors of which Kiora is not currently aware. The forward-looking statements in this press release speak only as of the date of this press release. Kiora expressly disclaims any obligation or undertaking to release publicly any updates or revisions to such statements to reflect any change in its expectations with regard thereto or any changes in the events, conditions, or circumstances on which any such statement is based, except as required by law.\n###\n\nContact: investors@kiorapharma.com\n\nCONDENSED CONSOLIDATED BALANCE SHEETS\n\n\n\n\n\nSeptember 30, 2024 (unaudited)\n\n\nDecember 31, 2023\n\n\n\nASSETS\n\n\n\n\n\n\n\n\nCurrent Assets:\n\n\n\n\n\n\n\n\nCash and Cash Equivalents\n$\n5,637,019 \n\n$\n2,454,684 \n\n\n\nShort-Term Investments\n\n23,398,016\n\n\n-\n\n\n\nPrepaid Expenses and Other Current Assets\n\n470,424\n\n\n233,382\n\n\n\nCollaboration Receivables\n\n1,783,472\n\n\n-\n\n\n\nTax and Other Receivables\n\n363,706\n\n\n2,049,965\n\n\n\nTotal Current Assets\n\n31,652,637\n\n\n4,738,031\n\n\n\nNon-Current Assets:\n\n \n\n\n \n\n\n\nProperty and Equipment, Net\n\n62,609\n\n\n8,065\n\n\n\nRestricted Cash\n\n4,520\n\n\n4,267\n\n\n\nIntangible Assets and In-Process R&D, Net\n\n6,687,100\n\n\n8,813,850\n\n\n\nOperating Lease Assets with Right-of-Use\n\n72,637\n\n\n106,890\n\n\n\nOther Assets\n\n29,851\n\n\n40,767\n\n\n\nTotal Assets\n$\n38,509,354\n\n$\n13,711,870\n\n\n\nLIABILITIES AND STOCKHOLDERS' EQUITY\n\n \n\n\n \n\n\n\nCurrent Liabilities:\n\n \n\n\n \n\n\n\nAccounts Payable\n$\n660,415\n\n$\n206,260\n\n\n\nAccrued Expenses\n\n1,714,211\n\n\n1,380,666\n\n\n\nAccrued Collaboration Credit\n\n1,119,591\n\n\n-\n\n\n\nOperating Lease Liabilities\n\n33,447\n\n\n47,069\n\n\n\nTotal Current Liabilities\n\n3,527,664\n\n\n1,633,995\n\n\n\nNon-Current Liabilities:\n\n \n\n\n \n\n\n\nContingent Consideration\n\n4,133,008\n\n\n5,128,959\n\n\n\nDeferred Tax Liability\n\n779,440\n\n\n779,440\n\n\n\nOperating Lease Liabilities\n\n39,190\n\n\n59,822\n\n\n\nTotal Non-Current Liabilities\n\n4,951,638\n\n\n5,968,221\n\n\n\nTotal Liabilities\n\n8,479,302\n\n\n7,602,216\n\n\n\nCommitments and Contingencies (Note 8)\n\n \n\n\n \n\n\n\nStockholders' Equity:\n\n \n\n\n \n\n\n\nPreferred Stock, $0.01 Par Value: 10,000,000 shares authorized; 3,750 designated Series A, 0 shares issued and outstanding; 10,000 designated Series B, 0 shares issued and outstanding; 10,000 shares designated Series C, 0 shares issued and outstanding; 20,000 shares designated Series D, 7 shares issued and outstanding; 1,280 shares designated Series E, 0 shares issued and outstanding; 3,908 shares designated Series F, 420 issued and outstanding at September 30, 2024 and December 31, 2023, respectively\n\n4\n\n\n4\n\n\n\nCommon Stock, $0.01 Par Value: 150,000,000 and 50,000,000 shares authorized; 3,000,788 and 856,182 shares issued and outstanding at September 30, 2024 and December 31, 2023, respectively\n\n267,679\n\n\n77,078\n\n\n\nAdditional Paid-In Capital\n\n168,996,195\n\n\n153,192,228\n\n\n\nAccumulated Deficit\n\n(139,158,620\n)\n\n(146,976,855\n)\n\n\nAccumulated Other Comprehensive Loss\n\n(75,206\n)\n\n(182,801\n)\n\n\nTotal Stockholders' Equity\n\n30,030,052\n\n\n6,109,654\n\n\n\nTotal Liabilities and Stockholders' Equity\n$\n38,509,354\n\n$\n13,711,870\n\n\n\n\nCONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE INCOME (LOSS)(unaudited)\n\n\n\n\n\nThree Months Ended September 30,\n\n\nNine Months Ended September 30,\n\n\n\n\n\n2024\n\n\n2023\n\n\n2024\n\n\n2023\n\n\n\nRevenue:\n\n\n\n\n \n\n\n \n\n\n \n\n\n\nCollaboration Revenue\n$\n - \n\n$\n-\n\n$\n16,000,000\n\n$\n-\n\n\n\nGrant Revenue\n\n-\n\n\n-\n\n\n20,000\n\n\n-\n\n\n\nTotal Revenue\n\n-\n\n\n-\n\n\n16,020,000\n\n\n-\n\n\n\nOperating Expenses:\n\n \n\n\n \n\n\n \n\n\n \n\n\n\nGeneral and Administrative\n\n1,380,997\n\n\n1,415,844\n\n\n4,215,411\n\n\n3,782,596\n\n\n\nResearch and Development\n\n1,317,231\n\n\n1,085,010\n\n\n3,717,570\n\n\n2,915,392\n\n\n\nIn-Process R&D Impairment\n\n2,008,000\n\n\n1,904,314\n\n\n2,008,000\n\n\n1,904,314\n\n\n\nChange in Fair Value of Contingent Consideration\n\n(1,103,991\n)\n\n1,513,400\n\n\n(995,951\n)\n\n1,865,945\n\n\n\nTotal Operating Expenses\n\n3,602,237\n\n\n5,918,568\n\n\n8,945,030\n\n\n10,468,247\n\n\n\nOperating Income (Loss)\n\n(3,602,237\n)\n\n(5,918,568\n)\n\n7,074,970\n\n\n(10,468,247\n)\n\n\nOther Income (Expense), Net:\n\n \n\n\n \n\n\n \n\n\n \n\n\n\nInterest Income, Net\n\n248,840\n\n\n49,912\n\n\n813,989\n\n\n128,464\n\n\n\nOther Income (Expense), Net\n\n(59,929\n)\n\n105,715\n\n\n(70,724\n)\n\n94,493\n\n\n\nTotal Other Income, Net\n\n188,911\n\n\n155,627\n\n\n743,265\n\n\n222,957\n\n\n\nNet Income (Loss)\n$\n(3,413,326\n)\n$\n(5,762,941\n)\n$\n7,818,235\n\n$\n(10,245,290\n)\n\n\nDeemed Dividends from Warrant Reset Provision\n\n-\n\n\n(530,985\n)\n\n-\n\n\n(530,985\n)\n\n\nNet Loss Attributable to Common Shareholders\n$\n(3,413,326\n)\n$\n(6,293,926\n)\n$\n7,818,235\n\n$\n(10,776,275\n)\n\n\nNet Income (Loss) per Common Share - Basic\n$\n(0.81\n)\n$\n(7.30\n)\n$\n2.08\n\n$\n(23.35\n)\n\n\nWeighted Average Shares Outstanding - Basic\n\n4,214,950\n\n\n789,656\n\n\n3,757,467\n\n\n438,687\n\n\n\nNet Income (Loss) per Common Share - Diluted\n$\n(0.81\n)\n$\n(7.30\n)\n$\n1.91\n\n$\n(23.35\n)\n\n\nWeighted Average Shares Outstanding - Diluted\n\n4,214,950\n\n\n789,656\n\n\n4,092,880\n\n\n438,687\n\n\n\n\n\n \n\n\n \n\n\n \n\n\n \n\n\n\nOther Comprehensive Income (Loss):\n\n \n\n\n \n\n\n \n\n\n \n\n\n\nNet Income (Loss)\n$\n(3,413,326\n)\n$\n(5,762,941\n)\n$\n7,818,235\n\n$\n(10,245,290\n)\n\n\nUnrealized Gain on Marketable Securities\n\n76,435\n\n\n-\n\n\n73,607\n\n\n-\n\n\n\nForeign Currency Translation Adjustments\n\n94,094\n\n\n(40,310\n)\n\n33,988\n\n\n(83,430\n)\n\n\nComprehensive Income (Loss)\n$\n(3,242,797\n)\n$\n(5,803,251\n)\n$\n7,925,830\n\n$\n(10,328,720\n)\n\n\n\nTo view the source version of this press release, please visit https://www.newsfilecorp.com/release/67320\n\nTo view the source version of this press release, please visit https://www.newsfilecorp.com/release/229204","kind":"highlight","is_publish_news":true,"is_publish_highlight":false,"is_publish_live":false,"is_publish_wemedia":null,"editions":null,"column":"","sentiment":"1","news_tag":"productRelease","news_rank":0,"symbols":[],"gpt_button":1},"commentList":[],"isCommentEnd":true,"newsSizeData":{"likeSize":0,"commentSize":0,"repostSize":0,"favoriteSize":0,"likeStatus":false,"favoriteStatus":false},"APP":{"userAgent":"Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; 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