Arcus Biosciences Reports Third-Quarter 2024 Financial Results and Provides a Pipeline Update

Business Wire11-07

Data from the Phase 1/1b ARC-20 study of casdatifan were presented at an oral plenary session at the 2024 EORTC-NCI-AACR Symposium; a low rate of primary progression (19%) and promising objective ...

Source Link

Disclaimer: Investing carries risk. This is not financial advice. The above content should not be regarded as an offer, recommendation, or solicitation on acquiring or disposing of any financial products, any associated discussions, comments, or posts by author or other users should not be considered as such either. It is solely for general information purpose only, which does not consider your own investment objectives, financial situations or needs. TTM assumes no responsibility or warranty for the accuracy and completeness of the information, investors should do their own research and may seek professional advice before investing.

Comments

We need your insight to fill this gap

Leave a comment

{"i18n":{"language":"en_US"},"isChannel":false,"data":{"share":"https://ttm.financial/m/news/2481952610?lang=en_US&edition=fundamental","thumbnail":"","is_english":true,"pubTime":"2024-11-07 05:22","share_image_url":"https://static.laohu8.com/5f26f4a48f9cb3e29be4d71d3ba8c038","id":"2481952610","market":"us","top_or_hot":-1,"title":"Arcus Biosciences Reports Third-Quarter 2024 Financial Results and Provides a Pipeline Update","media":"Business Wire","content":"<div>\n<p>Data from the Phase 1/1b ARC-20 study of casdatifan were presented at an oral plenary session at the 2024 EORTC-NCI-AACR Symposium; a low rate of primary progression (19%) and promising objective ...</p>\n\n<a href=\"https://finance.yahoo.com/news/arcus-biosciences-reports-third-quarter-212200285.html\">Source Link</a>\n\n</div>\n","source":"yahoofinance","html":"<!DOCTYPE html>\n<html>\n<head>\n<meta http-equiv=\"Content-Type\" content=\"text/html; charset=utf-8\" />\n<meta name=\"viewport\" content=\"width=device-width,initial-scale=1.0,minimum-scale=1.0,maximum-scale=1.0,user-scalable=no\"/>\n<meta name=\"format-detection\" content=\"telephone=no,email=no,address=no\" />\n<title>Arcus Biosciences Reports Third-Quarter 2024 Financial Results and Provides a Pipeline Update</title>\n<style type=\"text/css\">\na,abbr,acronym,address,applet,article,aside,audio,b,big,blockquote,body,canvas,caption,center,cite,code,dd,del,details,dfn,div,dl,dt,\nem,embed,fieldset,figcaption,figure,footer,form,h1,h2,h3,h4,h5,h6,header,hgroup,html,i,iframe,img,ins,kbd,label,legend,li,mark,menu,nav,\nobject,ol,output,p,pre,q,ruby,s,samp,section,small,span,strike,strong,sub,summary,sup,table,tbody,td,tfoot,th,thead,time,tr,tt,u,ul,var,video{ font:inherit;margin:0;padding:0;vertical-align:baseline;border:0 }\nbody{ font-size:16px; line-height:1.5; color:#999; background:transparent; }\n.wrapper{ overflow:hidden;word-break:break-all;padding:10px; }\nh1,h2{ font-weight:normal; line-height:1.35; margin-bottom:.6em; }\nh3,h4,h5,h6{ line-height:1.35; margin-bottom:1em; }\nh1{ font-size:24px; }\nh2{ font-size:20px; }\nh3{ font-size:18px; }\nh4{ font-size:16px; }\nh5{ font-size:14px; }\nh6{ font-size:12px; }\np,ul,ol,blockquote,dl,table{ margin:1.2em 0; }\nul,ol{ margin-left:2em; }\nul{ list-style:disc; }\nol{ list-style:decimal; }\nli,li p{ margin:10px 0;}\nimg{ max-width:100%;display:block;margin:0 auto 1em; }\nblockquote{ color:#B5B2B1; border-left:3px solid #aaa; padding:1em; }\nstrong,b{font-weight:bold;}\nem,i{font-style:italic;}\ntable{ width:100%;border-collapse:collapse;border-spacing:1px;margin:1em 0;font-size:.9em; }\nth,td{ padding:5px;text-align:left;border:1px solid #aaa; }\nth{ font-weight:bold;background:#5d5d5d; }\n.symbol-link{font-weight:bold;}\n/* header{ border-bottom:1px solid #494756; } */\n.title{ margin:0 0 8px;line-height:1.3;color:#ddd; }\n.meta {color:#5e5c6d;font-size:13px;margin:0 0 .5em; }\na{text-decoration:none; color:#2a4b87;}\n.meta .head { display: inline-block; overflow: hidden}\n.head .h-thumb { width: 30px; height: 30px; margin: 0; padding: 0; border-radius: 50%; float: left;}\n.head .h-content { margin: 0; padding: 0 0 0 9px; float: left;}\n.head .h-name {font-size: 13px; color: #eee; margin: 0;}\n.head .h-time {font-size: 11px; color: #7E829C; margin: 0;line-height: 11px;}\n.small {font-size: 12.5px; display: inline-block; transform: scale(0.9); -webkit-transform: scale(0.9); transform-origin: left; -webkit-transform-origin: left;}\n.smaller {font-size: 12.5px; display: inline-block; transform: scale(0.8); -webkit-transform: scale(0.8); transform-origin: left; -webkit-transform-origin: left;}\n.bt-text {font-size: 12px;margin: 1.5em 0 0 0}\n.bt-text p {margin: 0}\n</style>\n</head>\n<body>\n<div class=\"wrapper\">\n<header>\n<h2 class=\"title\">\nArcus Biosciences Reports Third-Quarter 2024 Financial Results and Provides a Pipeline Update\n</h2>\n\n<h4 class=\"meta\">\n\n\n2024-11-07 05:22 GMT+8&nbsp;&nbsp;&nbsp;<a href=https://finance.yahoo.com/news/arcus-biosciences-reports-third-quarter-212200285.html><strong>Business Wire</strong></a>\n\n\n</h4>\n\n</header>\n<article>\n<div>\n<p>Data from the Phase 1/1b ARC-20 study of casdatifan were presented at an oral plenary session at the 2024 EORTC-NCI-AACR Symposium; a low rate of primary progression (19%) and promising objective ...</p>\n\n<a href=\"https://finance.yahoo.com/news/arcus-biosciences-reports-third-quarter-212200285.html\">Source Link</a>\n\n</div>\n\n\n</article>\n</div>\n</body>\n</html>\n","isBrief":false,"type":0,"news_type":1,"symbol":"BK4503","symbol_name":"景林资产持仓","start_time":0,"source_url":"https://finance.yahoo.com/news/arcus-biosciences-reports-third-quarter-212200285.html","article_id":"2481952610","we_media_id":null,"thumbnails":[],"rights":null,"url":"https://stock-news.laohu8.com/highlight/detail?id=2481952610","pubTimestamp":1730928120,"sourceInfo":{"source_id":"yahoofinance","name":"雅虎金融"},"weMediaInfo":null,"summary":"Data from the Phase 1/1b ARC-20 study of casdatifan were presented at an oral plenary session at the 2024 EORTC-NCI-AACR Symposium; a low rate of primary progression (19%) and promising objective response rate  for the 100mg daily  cohort of heavily pretreated patients with clear-cell renal cell carcinoma  support a potential best-in-class profile. Arcus announced a clinical trial collaboration agreement with AstraZeneca to evaluate casdatifan in combination with volrustomig, an investigational PD-1/CTLA-4 bispecific antibody, in patients with immuno-oncology -naive ccRCC. Data from the randomized ARC-10 study will be presented at the Annual Meeting of the Society of Immunotherapy of Cancer ; domvanalimab plus zimberelimab reduced the risk of death in first-line metastatic non-small cell lung cancer  by 36% compared to zimberelimab. In October 2024, Arcus announced a clinical collaboration with AstraZeneca to evaluate casdatifan in combination with volrustomig, AstraZeneca’s investigat","collect":0,"end_time":0,"defaultTopTitle":"yahoo.com","property":[],"viewcount":null,"language":"en","relate_stocks":{"BK4503":"景林资产持仓","BK4166":"消费信贷","BK4195":"互助储蓄与抵押信贷金融服务","QD":"趣店","BK4080":"零售业房地产投资信托","BK4107":"财产与意外伤害保险","IO":"离子地球物理","BK4211":"区域性银行","SITC":"SITE Centers Corp.","RCUS":"Arcus Biosciences Inc.","BK4179":"石油天然气设备与服务","BK4585":"ETF&股票定投概念","BK4139":"生物科技","L":"洛斯公司","BK4588":"碎股","BK4563":"昨日强势股","PFS":"Provident Financial Services Inc","LU0053666078.USD":"摩根大通基金-美国股票A（离岸）美元","BK4231":"零售房地产信托"},"translate_title":"Arcus Biosciences报告2024年第三季度财务业绩并提供管道更新","themeId":null,"isJumpTheme":false,"ttsUrl":null,"symbols_score_info":{"SITC":1,"QD":1,"PFS":1,"L":1,"IO":1,"RCUS":0.9},"content_text":"Data from the Phase 1/1b ARC-20 study of casdatifan were presented at an oral plenary session at the 2024 EORTC-NCI-AACR Symposium; a low rate of primary progression (19%) and promising objective response rate (34% with 2 responses pending confirmation, 25% confirmed) for the 100mg daily (50mg twice-daily) cohort of heavily pretreated patients with clear-cell renal cell carcinoma (ccRCC) support a potential best-in-class profile\nArcus announced a clinical trial collaboration agreement with AstraZeneca to evaluate casdatifan in combination with volrustomig, an investigational PD-1/CTLA-4 bispecific antibody, in patients with immuno-oncology (IO)-naive ccRCC\nData from the randomized ARC-10 study will be presented at the Annual Meeting of the Society of Immunotherapy of Cancer (SITC); domvanalimab plus zimberelimab reduced the risk of death in first-line metastatic non-small cell lung cancer (NSCLC) by 36% compared to zimberelimab\nArcus is well positioned to advance its full pipeline with $1.1 billion in cash, cash equivalents and marketable securities and runway into mid-2027\n\nHAYWARD, Calif., November 06, 2024--(BUSINESS WIRE)--Arcus Biosciences, Inc. (NYSE:RCUS), a clinical-stage, global biopharmaceutical company focused on developing differentiated molecules and combination therapies for patients with cancer, today reported financial results for the third quarter ended September 30, 2024, and provided a pipeline update on its clinical-stage investigational molecules — targeting TIGIT, HIF-2a, CD73, the A2a/A2b receptors, CD-39, AXL and PD-1 — across multiple common cancers.\n\"Through the course of this year, we have presented multiple compelling datasets at medical conferences that we believe have de-risked several programs and support potential best-in-class profiles for our molecules, including our HIF-2a inhibitor casdatifan in ccRCC and our Fc-silent anti-TIGIT antibody domvanalimab in lung and upper gastrointestinal cancers,\" said Terry Rosen, Ph.D., chief executive officer of Arcus. \"Meanwhile, in addition to our rapidly approaching first Phase 3 readout for domvanalimab in gastric cancer, we are aggressively pursuing our development plan for casdatifan, including in the IO-naive ccRCC setting in collaboration with AstraZeneca, and in the post-IO setting with the initiation of our Phase 3 PEAK-1 study in the first half of next year.\"\nCorporate Updates:\n\nIn October 2024, Arcus announced a clinical collaboration with AstraZeneca to evaluate casdatifan in combination with volrustomig, AstraZeneca’s investigational PD-1/CTLA-4 bispecific antibody, in IO-naive patients with ccRCC. AstraZeneca will operationalize the study. This is the second clinical collaboration between Arcus and AstraZeneca. Gilead retains the right to opt in to the development and commercialization for casdatifan after delivery of a qualifying data package.\n\nPipeline Highlights:\nCasdatifan (HIF-2a inhibitor)\nCasdatifan Updates:\n\nFirst clinical data from the casdatifan 100mg and 50mg expansion cohorts of ARC-20, a Phase 1/1b study in metastatic ccRCC, were presented in an oral plenary session at the 2024 EORTC-NCI-AACR Symposium in October. Observations from the 100mg daily expansion cohort included:\n  \nAn objective response rate (ORR) of 34% (2 responses are pending confirmation; 25% confirmed ORR), a low rate of primary progression of 19% and a high disease control rate of 81%.\nThe median progression-free survival (PFS) had not been reached at the time of the data cutoff.\nTogether, these data support the potential for casdatifan to be a best-in-class HIF-2a inhibitor for the treatment of ccRCC.\n\nIn the third quarter, Arcus had a successful Type B meeting with the U.S. Federal Drug Administration (FDA) to discuss its first Phase 3 study for casdatifan, PEAK-1, which will evaluate casdatifan in combination with cabozantinib versus cabozantinib in post-IO patients with ccRCC. Arcus is moving rapidly toward the initiation of PEAK-1 in the first half of 2025.\n\nUpcoming Casdatifan Milestones:\n\nMultiple expansion cohorts of ARC-20 evaluating casdatifan in ccRCC as a monotherapy and in combination with cabozantinib in ccRCC are underway with additional data presentations expected in the next 12 months.\n  \n100mg (50mg twice daily (BID), capsules) and 50mg expansion cohorts: Updated data, including median PFS, are expected to be presented in the first quarter of 2025.\n150mg and 100mg (once daily (QD), tablets) expansion cohorts: Initial data are expected to be presented in 2025.\n100mg of casdatifan plus cabozantinib: Safety data are expected to be presented in 2025.\n\n\nDomvanalimab (Fc-silent anti-TIGIT antibody) plus Zimberelimab (anti-PD-1 antibody)\nDomvanalimab-Zimberelimab Updates:\n\nData from Part 1 of ARC-10, a randomized study evaluating domvanalimab plus zimberelimab in PD-L-1 high NSCLC are being presented at the SITC Annual Meeting in November.\nDomvanalimab plus zimberelimab was associated with greater PFS, overall survival, and objective response rate compared with zimberelimab or chemotherapy.\n  \nA 36% reduction in risk of death (hazard ratio [HR]=0.64) was observed for domvanalimab plus zimberelimab compared to that of zimberelimab alone.\nZimberelimab reached a median overall survival of 2 years, and the median overall survival for domvanalimab plus zimberelimab was not reached.\nTreatment-related adverse events leading to treatment discontinuation were low (10.5%) for the combination of domvanalimab and zimberelimab.\n\nData from an investigator-sponsored trial evaluating domvanalimab plus zimberelimab in anti-PD-(L)1 refractory hepatocellular carcinoma will be presented in an oral session at the SITC Annual Meeting.\n\nUpcoming Domvanalimab-Zimberelimab Milestones:\n\nOverall survival data from the Phase 2 EDGE-Gastric study, evaluating domvanalimab plus zimberelimab and chemotherapy in upper gastrointestinal (GI) adenocarcinomas, are expected to be presented in 2025.\n\nCD73-Adenosine Axis: Quemliclustat (small-molecule CD73 inhibitor) and Etrumadenant (A2a/A2b receptor antagonist)\nQuemliclustat\n\nArcus has initiated PRISM-1, a Phase 3 trial of quemliclustat combined with gemcitabine/nab-paclitaxel versus gemcitabine/nab-paclitaxel in pancreatic cancer.\n\nEtrumadenant\n\nBiomarker data from cohort B of ARC-9, a randomized Phase 1b/2 study evaluating etrumadenant plus zimberelimab, FOLFOX chemotherapy and bevacizumab (EZFB) versus regorafenib in third-line metastatic colorectal cancer (mCRC), are being presented at SITC in November.\n\nEarly Clinical Programs\n\nEvaluation of AB801, a potent and highly selective small-molecule AXL inhibitor, in the dose-escalation phase of a Phase 1/1b study in patients is ongoing. Arcus anticipates advancing this molecule into expansion cohorts in NSCLC in early 2025.\n\nFinancial Results for Third Quarter 2024:\n\nCash, Cash Equivalents and Marketable Securities were $1.1 billion as of September 30, 2024, compared to $866 million as of December 31, 2023. The increase during the period is primarily due to the receipt of $320 million in cash from Gilead for their January 2024 equity investment, the receipt of the $100 million option continuation payment from Gilead in July 2024 and proceeds from our $50 million term loan, partially offset by the use of cash in research and development activities. We believe our cash, cash equivalents and marketable securities on-hand will be sufficient to fund operations into mid-2027. Cash, cash equivalents and marketable securities are expected to be between $950 million and $985 million at the end of 2024.\nRevenues were $48 million for the third quarter 2024, compared to $32 million for the same period in 2023. In the third quarter 2024, Arcus recognized $41 million in license and development services revenue related to the advancement of programs and Taiho's exercise of its option for the license of quemliclustat for the Taiho Territory of $15 million, as well as $7 million in other collaboration revenue primarily related to Gilead’s ongoing rights to access Arcus’s research and development pipeline in accordance with the Gilead collaboration agreement.\nResearch and Development (R&D) Expenses were $123 million for the third quarter 2024, compared to $82 million for the same period in 2023. The net increase of $41 million was primarily driven by higher clinical trial and headcount-related costs associated with our late-stage development program activities. Non-cash stock-based compensation expense was $9 million for the third quarter 2024, compared to $8 million for the same period in 2023. For the third quarter 2024 and 2023, Arcus recognized gross reimbursements of $37 million and $33 million, respectively, for shared expenses from its collaborations, primarily the Gilead collaboration. R&D expense by quarter may fluctuate due to the timing of clinical manufacturing and standard-of-care therapeutic purchases with a corresponding impact on reimbursements.\nGeneral and Administrative (G&A) Expenses were flat for the third quarter 2024, compared to the same period in 2023. Non-cash stock-based compensation expense was $10 million for each of the third quarter 2024 and 2023.\nNet Loss was $92 million for the third quarter 2024, compared to $71 million for the same period in 2023.\n\nConference Call Information:\nArcus will host a conference call and webcast today, November 6, at 2:00 PM PT/5:00 PM ET to discuss its third-quarter 2024 financial results and pipeline updates. To access the call, please dial +1 (404) 975-4839 (local) or +1 (833) 470-1428 (toll-free), using Access Code: 940081. Participants may also register for the call online using the following link: https://www.netroadshow.com/events/login?show=4818aee3&confId=72838. To access the live webcast and accompanying slide presentation, please visit the \"Investors & Media\" section of the Arcus Biosciences website at www.arcusbio.com. A replay of the webcast will be available following the live event.\nArcus Ongoing and Announced Clinical Studies:\n\n\n\nTrial Name\nArms\nSetting\nStatus\nNCT No.\n\n\nLung Cancer\n\n\nSTAR-121\ndom + zim + chemo vs. pembro + chemo\n1L NSCLC (PD-L1 all-comers)\nOngoing Registrational Phase 3\nNCT05502237\n\n\nPACIFIC-8\ndom + durva vs. durva\nUnresectable Stage 3 NSCLC\nOngoing Registrational Phase 3\nNCT05211895\n\n\nARC-7\nzim vs. dom + zim vs. etruma + dom + zim\n1L NSCLC (PD-L1 ≥ 50%)\nOngoing Randomized Phase 2\nNCT04262856\n\n\nEDGE-Lung\ndom +/- zim +/- quemli +/- chemo\n1L/2L NSCLC (lung cancer platform study)\nOngoing Randomized Phase 2\nNCT05676931\n\n\nVELOCITY-Lung\ndom +/- zim +/- etruma +/- sacituzumab govitecan-hziy or other combos\n1L/2L NSCLC (lung cancer platform study)\nOngoing Randomized Phase 2\nNCT05633667\n\n\nUpper Gastrointestinal Cancers\n\n\nSTAR-221\ndom + zim + chemo vs. nivo + chemo\n1L Gastric, GEJ and EAC\nOngoing Registrational Phase 3\nNCT05568095\n\n\nEDGE-Gastric (ARC-21)\ndom +/- zim +/- quemli +/- chemo\n1L/2L Upper GI Malignancies\nOngoingRandomized Phase 2\nNCT05329766\n\n\nColorectal Cancer\n\n\nARC-9\netruma + zim + mFOLFOX vs. SOC\n2L/3L/3L+ CRC\nOngoingRandomized Phase 2\nNCT04660812\n\n\nPancreatic Cancer\n\n\nPRISM-1\nquemli + gem/nab-pac vs. gem/nab-pac\n1L PDAC\nOngoing Phase 3\nNCT06608927\n\n\nARC-8\nquemli + zim + gem/nab-pac vs. quemli + gem/nab-pac\n1L, 2L PDAC\nOngoing Randomized Phase 1/1b\nNCT04104672\n\n\nKidney Cancer\n\n\nPEAK-1\ncas + cabo vs. cabo\nPost-IO ccRCC\nPlanned Phase 3\nTBD\n\n\nARC-20\ncas, cas + cabo\nCancer Patients/ccRCC\nOngoing Phase 1/1b\nNCT05536141\n\n\nOther\n\n\nARC-25\nAB598\nAdvanced Malignancies\nOngoing\nNCT05891171\n\n\nARC-27\nAB801\nAdvanced Malignancies\nOngoing\nNCT06120075\n\n\n\ncabo: cabozantinib; cas: casdatifan; dom: domvanalimab; durva: durvalumab; etruma: etrumadenant; gem/nab-pac: gemcitabine/nab-paclitaxel; nivo: nivolumab; pembro: pembrolizumab; quemli: quemliclustat; SOC: standard of care; zim: zimberelimab; ccRCC: clear cell renal cell carcinoma; CRC: colorectal cancer; EAC: esophageal adenocarcinoma; GEJ: gastroesophageal junction; GI: gastrointestinal; NSCLC: non-small cell lung cancer; PDAC: pancreatic ductal adenocarcinoma\nAbout the Gilead Collaboration\nIn May 2020, Arcus established a 10-year collaboration with Gilead to strategically advance our portfolio. Under this collaboration, Gilead obtained time-limited exclusive option rights to all of our clinical programs arising during the collaboration term. Arcus and Gilead are co-developing four investigational products, including zimberelimab (Arcus’s anti-PD-1 molecule), domvanalimab (Arcus’s anti-TIGIT antibody), etrumadenant (Arcus’s adenosine receptor antagonist) and quemliclustat (Arcus’s CD73 inhibitor). The collaboration was expanded in November 2021 and May 2023 to include research directed to two targets for oncology and two targets for inflammatory diseases.\nAbout Arcus Biosciences\nArcus Biosciences is a clinical-stage, global biopharmaceutical company developing differentiated molecules and combination medicines for people with cancer. In partnership with industry collaborators, patients and physicians around the world, Arcus is expediting the development of first- or best-in-class medicines against well-characterized biological targets and pathways and studying novel, biology-driven combinations that have the potential to help people with cancer live longer. Founded in 2015, the company has expedited the development of multiple investigational medicines into clinical studies, including new combination approaches that target TIGIT, PD-1, HIF-2a, CD73, dual A2a/A2b receptor, CD39 and AXL. For more information about Arcus Biosciences’ clinical and preclinical programs, please visit www.arcusbio.com.\nDomvanalimab, etrumadenant, quemliclustat and zimberelimab are investigational molecules, and neither Gilead nor Arcus has received approval from any regulatory authority for any use globally, and their safety and efficacy have not been established. Casdatifan, AB598 and AB801 are also investigational molecules, and Arcus has not received approval from any regulatory authority for any use globally, and their safety and efficacy have not been established.\nForward-Looking Statements\nThis press release contains forward-looking statements. All statements regarding events or results to occur in the future contained herein are forward-looking statements reflecting the current beliefs and expectations of management made pursuant to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995, including, but not limited to, the statements in Dr. Rosen’s quote and statements regarding: Arcus’s expectation that its cash, cash equivalents and marketable securities on-hand are sufficient to fund operations into mid-2027; plans to disclose or present study analyses or data, including any analyses or data from ARC-20 or EDGE-Gastric; whether data and results from studies validate our pipeline or support further development of a program; the potency, efficacy or safety of Arcus’s investigational products, including their potential for a best-in-class profile; and the initiation, design of and associated timing for future studies, including statements about PEAK-1 and PRISM-1. All forward-looking statements involve known and unknown risks and uncertainties and other important factors that may cause Arcus’s actual results, performance or achievements to differ significantly from those expressed or implied by the forward-looking statements. Factors that could cause or contribute to such differences include, but are not limited to: risks associated with preliminary and interim data not being guarantees that future data will be similar; the unexpected emergence of adverse events or other undesirable side effects in Arcus’s investigational products; difficulties or delays in initiating or conducting clinical trials due to difficulties or delays in the regulatory process, enrolling subjects or manufacturing or supplying product for such clinical trials; unfavorable global economic, political and trade conditions; Arcus’s dependence on the collaboration with third parties such as Gilead and Taiho for the successful development and commercialization of its optioned molecules; difficulties associated with the management of the collaboration activities or expanded clinical programs; changes in the competitive landscape for Arcus’s programs; and the inherent uncertainty associated with pharmaceutical product development and clinical trials. Risks and uncertainties facing Arcus are described more fully in the \"Risk Factors\" section of Arcus’s most recent periodic report filed with the U.S. Securities and Exchange Commission. You are cautioned not to place undue reliance on the forward-looking statements, which speak only as of the date of this press release. Arcus disclaims any obligation or undertaking to update, supplement or revise any forward-looking statements contained in this press release except to the extent required by law.\nThe Arcus name and logo are trademarks of Arcus Biosciences, Inc. All other trademarks belong to their respective owners.\n\n\n\nARCUS BIOSCIENCES, INC.\n\n\nConsolidated Statements of Operations\n\n\n(unaudited)\n\n\n(In millions, except per share amounts)\n\n\n\n\n\n \n\n\n\nThree Months Ended September 30,\n\nNine Months Ended September 30,\n\n\n\n\n2024\n\n\n\n2023\n\n\n\n2024\n\n\n\n2023\n\n\n\nRevenues:\n\n\n\n\n\n\n\n\n\nLicense and development services revenue\n$\n41\n\n\n$\n22\n\n\n$\n204\n\n\n$\n58\n\n\n\nOther collaboration revenue\n\n7\n\n\n\n10\n\n\n\n28\n\n\n\n28\n\n\n\nTotal revenues\n\n48\n\n\n\n32\n\n\n\n232\n\n\n\n86\n\n\n\n\n\n\n\n\n\n\n\n\n\nOperating expenses:\n\n\n\n\n\n\n\n\n\nResearch and development\n\n123\n\n\n\n82\n\n\n\n347\n\n\n\n247\n\n\n\nGeneral and administrative\n\n30\n\n\n\n30\n\n\n\n92\n\n\n\n88\n\n\n\nImpairment of long-lived assets\n\n—\n\n\n\n—\n\n\n\n20\n\n\n\n—\n\n\n\nTotal operating expenses\n\n153\n\n\n\n112\n\n\n\n459\n\n\n\n335\n\n\n\n\n\n\n\n\n\n\n\n\n\nLoss from operations\n\n(105\n)\n\n\n(80\n)\n\n\n(227\n)\n\n\n(249\n)\n\n\n\n\n\n\n\n\n\n\n\n\nNon-operating income (expense):\n\n\n\n\n\n\n\n\n\nInterest and other income, net\n\n14\n\n\n\n12\n\n\n\n40\n\n\n\n30\n\n\n\nInterest expense\n\n(1\n)\n\n\n(1\n)\n\n\n(2\n)\n\n\n(2\n)\n\n\nTotal non-operating income, net\n\n13\n\n\n\n11\n\n\n\n38\n\n\n\n28\n\n\n\n\n\n\n\n\n\n\n\n\n\nLoss before income taxes\n\n(92\n)\n\n\n(69\n)\n\n\n(189\n)\n\n\n(221\n)\n\n\n\n\n\n\n\n\n\n\n\n\nIncome tax expense\n\n—\n\n\n\n(2\n)\n\n\n—\n\n\n\n(5\n)\n\n\n\n\n\n\n\n\n\n\n\n\nNet loss\n$\n(92\n)\n\n$\n(71\n)\n\n$\n(189\n)\n\n$\n(226\n)\n\n\n\n\n\n\n\n\n\n\n\n\nNet loss per share:\n\n\n\n\n\n\n\n\n\nBasic and diluted\n$\n(1.00\n)\n\n$\n(0.94\n)\n\n$\n(2.11\n)\n\n$\n(3.07\n)\n\n\n\n\n\n\n\n\n\n\n\n\nShares used to compute net loss per share:\n\n\n\n\n\n\n\n\n\nBasic and diluted\n\n91.4\n\n\n\n74.6\n\n\n\n89.6\n\n\n\n73.6\n\n\n\n\n\n\n\nSelected Consolidated Balance Sheet Data\n\n\n(unaudited)\n\n\n(In millions)\n\n\n\n\n\n \n\n\n\nSeptember 30, 2024\n\nDecember 31, 2023 (1)\n\n\nCash, cash equivalents and marketable securities\n$\n1,091\n\n$\n866\n\n\nTotal assets\n\n1,252\n\n\n1,095\n\n\nTotal liabilities\n\n687\n\n\n633\n\n\nTotal stockholders’ equity\n\n565\n\n\n462\n\n\n\n\n\n\n(1)\n\nDerived from the audited financial statements for the quarter ended December 31, 2023, included in the Company's Annual Report on Form 10-K filed with the Securities and Exchange Commission on February 21, 2024.\n\n\n\nView source version on businesswire.com: https://www.businesswire.com/news/home/20241106838612/en/\nContacts\nInvestor Inquiries: Pia EavesVP of Investor Relations & Strategy(617) 459-2006peaves@arcusbio.com\nMedia Inquiries: Holli KolkeyVP of Corporate Affairs(650) 922-1269hkolkey@arcusbio.com","kind":null,"is_publish_news":true,"is_publish_highlight":false,"is_publish_live":false,"is_publish_wemedia":null,"editions":null,"column":"","sentiment":"0","news_tag":"","news_rank":0,"symbols":[],"gpt_button":1},"commentList":[],"isCommentEnd":true,"newsSizeData":{"likeSize":0,"commentSize":0,"repostSize":0,"favoriteSize":0,"likeStatus":false,"favoriteStatus":false},"APP":{"userAgent":"Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)","isDev":false,"isTTM":true,"deviceId":"web-server-community-laohu8-v3","version":"4.29.1","shortVersion":"4.29.1","platform":"web","vendor":"web","appName":"ttm","isIOS":false,"isAndroid":false,"isTiger":false,"isTHS":false,"isWeiXin":false,"isWeiXinMini":false,"isWeiBo":false,"isQQ":false,"isBaiduSwan":false,"isBaiduBox":false,"isDingTalk":false,"isToutiao":false,"isOnePlus":false,"isHuaWei":false,"isXiaomi":false,"isXiaomiWebView":false,"isOppo":false,"isVivo":false,"isSamsung":false,"isMobile":false},"href":"/m/news/2481952610"}