Spruce Biosciences Reports Third Quarter 2024 Financial Results and Provides Corporate Updates

Business Wire11-11

Topline Data from CAHmelia-204 Study of Tildacerfont in Adult Congenital Adrenal Hyperplasia (CAH) Anticipated in December 2024 Topline Data from CAHptain-205 Study of Tildacerfont in Adult and ...

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overflow: hidden}\n.head .h-thumb { width: 30px; height: 30px; margin: 0; padding: 0; border-radius: 50%; float: left;}\n.head .h-content { margin: 0; padding: 0 0 0 9px; float: left;}\n.head .h-name {font-size: 13px; color: #eee; margin: 0;}\n.head .h-time {font-size: 11px; color: #7E829C; margin: 0;line-height: 11px;}\n.small {font-size: 12.5px; display: inline-block; transform: scale(0.9); -webkit-transform: scale(0.9); transform-origin: left; -webkit-transform-origin: left;}\n.smaller {font-size: 12.5px; display: inline-block; transform: scale(0.8); -webkit-transform: scale(0.8); transform-origin: left; -webkit-transform-origin: left;}\n.bt-text {font-size: 12px;margin: 1.5em 0 0 0}\n.bt-text p {margin: 0}\n</style>\n</head>\n<body>\n<div class=\"wrapper\">\n<header>\n<h2 class=\"title\">\nSpruce Biosciences Reports Third Quarter 2024 Financial Results and Provides Corporate Updates\n</h2>\n\n<h4 class=\"meta\">\n\n\n2024-11-11 21:00 GMT+8&nbsp;&nbsp;&nbsp;<a href=https://finance.yahoo.com/news/spruce-biosciences-reports-third-quarter-130000514.html><strong>Business Wire</strong></a>\n\n\n</h4>\n\n</header>\n<article>\n<div>\n<p>Topline Data from CAHmelia-204 Study of Tildacerfont in Adult Congenital Adrenal Hyperplasia (CAH) Anticipated in December 2024\nTopline Data from CAHptain-205 Study of Tildacerfont in Adult and ...</p>\n\n<a href=\"https://finance.yahoo.com/news/spruce-biosciences-reports-third-quarter-130000514.html\">Source Link</a>\n\n</div>\n\n\n</article>\n</div>\n</body>\n</html>\n","isBrief":false,"type":0,"news_type":1,"symbol":"SPRB","symbol_name":"Spruce Biosciences, Inc.","start_time":0,"source_url":"https://finance.yahoo.com/news/spruce-biosciences-reports-third-quarter-130000514.html","article_id":"2482895047","we_media_id":null,"thumbnails":["https://s.yimg.com/uu/api/res/1.2/rsQhwehUjU_j8qqoqA0CuQ--~B/aD01MTI7dz0xMDI0O2FwcGlkPXl0YWNoeW9u/https://media.zenfs.com/en/business-wire.com/084a09e7aa29b73de188ce7e9dcd7516"],"rights":null,"url":"https://stock-news.laohu8.com/highlight/detail?id=2482895047","pubTimestamp":1731330000,"sourceInfo":{"source_id":"yahoofinance","name":"雅虎金融"},"weMediaInfo":null,"summary":"Topline Data from CAHmelia-204 Study of Tildacerfont in Adult Congenital Adrenal Hyperplasia  Anticipated in December 2024. Topline Data from CAHptain-205 Study of Tildacerfont in Adult and Pediatric CAH Anticipated in December 2024. CAHptain-205 Study of Tildacerfont in Adult and Pediatric CAH: CAHptain-205 is a Phase 2 open-label clinical trial, which utilizes a sequential nine cohort design, to evaluate the safety, efficacy, and pharmacokinetics of tildacerfont in adults and children between two and 17 years of age. Cohorts 1-3 evaluated weight-adjusted doses of tildacerfont between 50mg QD and 200mg QD in pediatric CAH patients between two and 17 years of age, and assessed changes in androgen levels over 12 weeks of treatment as well as the ability to reduce daily GC dose based on A4 normali","collect":0,"end_time":0,"defaultTopTitle":"yahoo.com","property":[],"viewcount":null,"language":"en","relate_stocks":{"SPRB":"Spruce Biosciences, Inc.","LU0128525689.USD":"TEMPLETON GLOBAL BALANCED \"A\"(USD) ACC","LU0072461881.USD":"BGF US BASIC VALUE \"A2\" ACC","CAH":"卡地纳健康","LU0310799852.SGD":"FTIF - Templeton Global Equity Income A MDIS SGD","LU1267930813.SGD":"FRANKLIN TEMPLETON SHARIAH GLOBAL EQUITY \"AS\" (SGD) ACC","LU0310800965.SGD":"FTIF - Templeton Global Balanced A Acc SGD","BK4563":"昨日强势股","BK4175":"保健护理产品经销商","LU0006061336.USD":"Blackrock US Small and MidCap Opportunities A2 USD","LU0211327993.USD":"TEMPLETON GLOBAL EQUITY INCOME \"A\" (USD) ACC","LU1267930490.SGD":"TEMPLETON GLOBAL EQUITY INCOME \"AS\" (SGD) INC A","BK4139":"生物科技","BK4585":"ETF&股票定投概念","SG9999001440.SGD":"United Global Dividend Equity Fund A SGD Dist","LU0211328371.USD":"TEMPLETON GLOBAL EQUITY INCOME \"A\" (MDIS) (USD)   INC","LU1571399168.USD":"ALLSPRING GLOBAL LONG/SHORT EQUITY \"IP\" (USD) ACC","LU0889566641.SGD":"FTSF - Templeton Shariah Global Equity A Acc SGD","LU0162691827.USD":"BGF US BASIC VALUE \"A4\" INC","LU1880398554.USD":"AMUNDI FUNDS GLOBAL EQUITY \"A2\" (USD) INC","LU1880398471.USD":"AMUNDI FUNDS GLOBAL EQUITY \"A2\" (USD) ACC","BK4166":"消费信贷","LU0052756011.USD":"TEMPLETON GLOBAL BALANCED \"A\" (USD) INC","BK4588":"碎股","LU0792757196.USD":"TEMPLETON SHARIAH GLOBAL EQUITY FUND \"A\" (USD) ACC","BK4503":"景林资产持仓","QD":"趣店","LU1267930227.SGD":"TEMPLETON GLOBAL BALANCED \"AS\" (SGD) ACC A"},"translate_title":"Spruce Biosciences报告2024年第三季度财务业绩并提供公司最新动态","themeId":null,"isJumpTheme":false,"ttsUrl":null,"symbols_score_info":{"SPRB":1,"QD":1,"CAH":1},"content_text":"Topline Data from CAHmelia-204 Study of Tildacerfont in Adult Congenital Adrenal Hyperplasia (CAH) Anticipated in December 2024\nTopline Data from CAHptain-205 Study of Tildacerfont in Adult and Pediatric CAH Anticipated in December 2024\nCash Runway Through the End of 2025\nSOUTH SAN FRANCISCO, Calif., November 11, 2024--(BUSINESS WIRE)--Spruce Biosciences, Inc. (Nasdaq: SPRB), a late-stage biopharmaceutical company focused on developing and commercializing novel therapies for endocrine and neurological disorders with significant unmet medical need, today reported financial results for the third quarter ended September 30, 2024 and provided corporate updates.\n\"We remain on track to report primary efficacy and safety data plus interim data from the open-label extension of the CAHmelia-204 study of tildacerfont in adult CAH patients in December 2024. At the same time, we will also report topline dose-ranging efficacy and safety data from the CAHptain-205 study of tildacerfont in adult and pediatric CAH patients,\" said Javier Szwarcberg, M.D., M.P.H., Chief Executive Officer of Spruce. \"It is an honor to continue partnering with the CAH community to open a new chapter in the management of CAH. We recognize the potentially transformative impact of tildacerfont, and we have a strong sense of urgency to deliver on our commitment to CAH patients.\"\nCorporate Updates\nCAHmelia-204 Study of Tildacerfont in Adult CAH: CAHmelia-204 is a Phase 2b, randomized, double-blind, placebo-controlled clinical trial to evaluate the safety and efficacy of tildacerfont in reducing supraphysiologic glucocorticoid (GC) usage, a potentially registrational endpoint, in 90 adults with classic CAH on supraphysiologic doses of GCs with normal or near normal levels of androstenedione (A4) at baseline. In the first part of the clinical trial, patients were randomized to receive 200mg of tildacerfont once-daily (QD) or placebo for 24 weeks. During the second part of the clinical trial, all patients received 200mg of tildacerfont QD for 52 weeks. Throughout the trial, tapering of GCs is guided according to a pre-specified algorithm and continue to physiologic replacement levels, as long as patients remain well controlled based on standard biomarkers and clinical assessments. The primary endpoint of this clinical trial is the absolute change in daily GC dose in hydrocortisone equivalents (HCe) from baseline through week 24.\nCAHptain-205 Study of Tildacerfont in Adult and Pediatric CAH: CAHptain-205 is a Phase 2 open-label clinical trial, which utilizes a sequential nine cohort design, to evaluate the safety, efficacy, and pharmacokinetics of tildacerfont in adults and children between two and 17 years of age. Cohorts 1-3 evaluated weight-adjusted doses of tildacerfont between 50mg QD and 200mg QD in pediatric CAH patients between two and 17 years of age, and assessed changes in androgen levels over 12 weeks of treatment as well as the ability to reduce daily GC dose based on A4 normalization. Cohorts 4-9 are evaluating weight-adjusted doses of tildacerfont of 200mg twice-daily (BID) and 400mg BID in adults and children between two and 17 years of age and is assessing changes in androgen levels over four weeks of treatment. An optional open-label extension period will provide additional open-label treatment with tildacerfont to provide long-term safety data for up to two years.\nAnticipated Upcoming Milestones\n\nTopline results from the CAHmelia-204 clinical trial of tildacerfont 200mg QD in adult classic CAH patients on supraphysiologic doses of GCs with normal or near normal levels of A4 anticipated in December 2024\nTopline results from the CAHptain-205 clinical trial of tildacerfont 200mg BID and 400mg BID adult and pediatric cohorts anticipated in December 2024\nEnd of Phase 2 (EOP2) meeting with the U.S. Food and Drug Administration anticipated in the first half of 2025\n\nThird Quarter 2024 Financial Results\n\nCash and Cash Equivalents: Cash and cash equivalents as of September 30, 2024 were $60.1 million. Cash and cash equivalents are expected to allow the company to fund its current operating plan through the end of 2025.\nCollaboration Revenue: Collaboration revenue was $0.6 million and $4.2 million for the three and nine months ended September 30, 2024, respectively, compared to $3.1 million and $7.2 million for the same periods in 2023. The collaboration revenue reflects the partial recognition of the $15.0 million upfront payment the company received in April 2023 in connection with the collaboration and license agreement with Kaken Pharmaceutical.\nResearch and Development (R&D) Expenses: R&D expenses for the three and nine months ended September 30, 2024 were $6.6 million and $25.0 million, respectively, compared to $13.5 million and $38.3 million for the same periods in 2023. The overall decrease in R&D expenses was primarily driven by the decrease in clinical development and manufacturing expenses related to the termination of the CAHmelia-203 study, completion of enrollment in the company’s CAHmelia-204 study, and completion of the Phase 2 POWER study in polycystic ovary syndrome, offset by an increase in expenses related to the ongoing CAHptain-205 study.\nGeneral and Administrative (G&A) Expenses: G&A expenses for the three and nine months ended September 30, 2024 were $3.5 million and $11.3 million, respectively, compared to $3.2 million and $9.7 million for the same periods in 2023.\nTotal Operating Expenses: Total operating expenses for the three and nine months ended September 30, 2024 were $10.0 million and $36.3 million, respectively, compared to $16.7 million and $48.0 million for the same periods in 2023. Operating expenses include non-cash stock-based compensation expenses of $1.1 million and $4.4 million for the three and nine months ended September 30, 2024, respectively, compared to $1.1 million and $3.4 million for the same periods in 2023.\nNet Loss: Net loss for the three and nine months ended September 30, 2024 was $8.7 million and $29.5 million, respectively, compared to $12.4 million and $38.0 million for the same periods in 2023.\n\nUpcoming Investor Conferences\nJavier Szwarcberg, M.D., M.P.H., Chief Executive Officer, will present at the Guggenheim Securities Healthcare Innovation Conference on November 11, 2024, at 3:30 p.m. ET.\nInterested parties can access the live webcast here. An archived copy of the webcast will be available on the events section of the company’s investor relations website for approximately 90 days.\nAbout Spruce Biosciences\nSpruce Biosciences is a late-stage biopharmaceutical company focused on developing and commercializing novel therapies for endocrine and neurological disorders with significant unmet medical need. Spruce is developing its product candidate, tildacerfont, an oral, second-generation CRF1 receptor antagonist, for the treatment of congenital adrenal hyperplasia (CAH), polycystic ovary syndrome (PCOS) and major depressive disorder (MDD). To learn more, visit www.sprucebio.com and follow us on X, LinkedIn, Facebook and YouTube.\nForward-Looking Statements\nStatements contained in this press release regarding matters that are not historical facts are \"forward-looking statements\" within the meaning of the Private Securities Litigation Reform Act of 1995. Such forward-looking statements include statements regarding, among other things, the design, results, conduct, progress and timing of Spruce’s clinical trials; Spruce’s expectations regarding reporting results of its clinical trials in 2024; Spruce’s plans to meet with the FDA to discuss the potential registrational path forward of tildacerfont for adult and pediatric classic CAH; and Spruce’s product candidate, strategy and regulatory matters. Because such statements are subject to risks and uncertainties, actual results may differ materially from those expressed or implied by such forward-looking statements. Words such as \"anticipate,\" \"continue,\" \"will,\" \"potential,\" \"on track,\" and similar expressions are intended to identify forward-looking statements. These forward-looking statements are based upon Spruce’s current expectations and involve assumptions that may never materialize or may prove to be incorrect. Actual results could differ materially from those anticipated in such forward-looking statements as a result of various risks and uncertainties, which include, without limitation, risks and uncertainties associated with Spruce’s business in general, the impact of geopolitical and macroeconomic events, and the other risks described in Spruce’s filings with the U.S. Securities and Exchange Commission. All forward-looking statements contained in this press release speak only as of the date on which they were made and are based on management’s assumptions and estimates as of such date. Spruce undertakes no obligation to update such statements to reflect events that occur or circumstances that exist after the date on which they were made, except as required by law.\n\n\n\nSPRUCE BIOSCIENCES, INC.CONDENSED BALANCE SHEETS(unaudited)(in thousands, except share and per share amounts)\n\n\n\n\n\n\n \n\n\n\n\nSeptember 30,\n\nDecember 31,\n\n\n\n\n2024\n\n2023\n\n\nASSETS\n\n\n\n\n\n\nCurrent assets:\n\n\n\n\n\n\nCash and cash equivalents\n\n$\n60,055\n\n\n$\n96,339\n\n\n\nPrepaid expenses\n\n\n2,658\n\n\n\n3,876\n\n\n\nOther current assets\n\n\n860\n\n\n\n1,968\n\n\n\nTotal current assets\n\n\n63,573\n\n\n\n102,183\n\n\n\nRight-of-use assets\n\n\n998\n\n\n\n1,181\n\n\n\nOther assets\n\n\n531\n\n\n\n582\n\n\n\nTotal assets\n\n$\n65,102\n\n\n$\n103,946\n\n\n\nLIABILITIES AND STOCKHOLDERS’ EQUITY\n\n\n\n\n\n\nCurrent liabilities:\n\n\n\n\n\n\nAccounts payable\n\n$\n1,799\n\n\n$\n3,332\n\n\n\nAccrued expenses and other current liabilities\n\n\n7,740\n\n\n\n14,600\n\n\n\nTerm loan, current portion\n\n\n1,622\n\n\n\n1,622\n\n\n\nDeferred revenue, current portion\n\n\n697\n\n\n\n4,911\n\n\n\nTotal current liabilities\n\n\n11,858\n\n\n\n24,465\n\n\n\nLease liabilities, net of current portion\n\n\n809\n\n\n\n1,019\n\n\n\nTerm loan, net of current portion\n\n\n524\n\n\n\n1,717\n\n\n\nOther liabilities\n\n\n273\n\n\n\n236\n\n\n\nTotal liabilities\n\n\n13,464\n\n\n\n27,437\n\n\n\nCommitments and contingencies\n\n\n\n\n\n\nStockholders’ equity:\n\n\n\n\n\n\nPreferred stock, $0.0001 par value; 10,000,000 shares authorized and no shares issued or outstanding as of September 30, 2024 and December 31, 2023\n\n\n—\n\n\n\n—\n\n\n\nCommon stock, $0.0001 par value; 200,000,000 shares authorized as of September 30, 2024 and December 31, 2023; 41,302,599 and 41,029,832 shares issued and outstanding as of September 30, 2024 and December 31, 2023, respectively\n\n\n4\n\n\n\n4\n\n\n\nAdditional paid-in capital\n\n\n278,343\n\n\n\n273,737\n\n\n\nAccumulated deficit\n\n\n(226,709\n)\n\n\n(197,232\n)\n\n\nTotal stockholders’ equity\n\n\n51,638\n\n\n\n76,509\n\n\n\nTotal liabilities and stockholders’ equity\n\n$\n65,102\n\n\n$\n103,946\n\n\n\n\n\n\n\nSPRUCE BIOSCIENCES, INC.CONDENSED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS(unaudited)(in thousands, except share and per share amounts)\n\n\n\n\n\n\n \n\n\n\n\nThree Months EndedSeptember 30,\n\nNine Months EndedSeptember 30,\n\n\n\n\n2024\n\n2023\n\n2024\n\n2023\n\n\nCollaboration revenue\n\n$\n602\n\n\n$\n3,073\n\n\n$\n4,214\n\n\n$\n7,202\n\n\n\nOperating expenses:\n\n\n\n\n\n\n\n\n\n\nResearch and development\n\n\n6,554\n\n\n\n13,494\n\n\n\n24,961\n\n\n\n38,332\n\n\n\nGeneral and administrative\n\n\n3,456\n\n\n\n3,237\n\n\n\n11,330\n\n\n\n9,699\n\n\n\nTotal operating expenses\n\n\n10,010\n\n\n\n16,731\n\n\n\n36,291\n\n\n\n48,031\n\n\n\nLoss from operations\n\n\n(9,408\n)\n\n\n(13,658\n)\n\n\n(32,077\n)\n\n\n(40,829\n)\n\n\nInterest expense\n\n\n(71\n)\n\n\n(119\n)\n\n\n(251\n)\n\n\n(377\n)\n\n\nInterest income and other expense, net\n\n\n808\n\n\n\n1,423\n\n\n\n2,851\n\n\n\n3,237\n\n\n\nNet loss\n\n\n(8,671\n)\n\n\n(12,354\n)\n\n\n(29,477\n)\n\n\n(37,969\n)\n\n\nOther comprehensive gain, net of tax:\n\n\n\n\n\n\n\n\n\n\nUnrealized gain on available for sale securities\n\n\n—\n\n\n\n52\n\n\n\n—\n\n\n\n555\n\n\n\nTotal comprehensive loss\n\n$\n(8,671\n)\n\n$\n(12,302\n)\n\n$\n(29,477\n)\n\n$\n(37,414\n)\n\n\nNet loss per share, basic and diluted\n\n$\n(0.21\n)\n\n$\n(0.30\n)\n\n$\n(0.72\n)\n\n$\n(1.01\n)\n\n\nWeighted-average shares of common stock outstanding, basic and diluted\n\n\n41,302,599\n\n\n\n40,710,692\n\n\n\n41,187,766\n\n\n\n37,751,865\n\n\n\n\nView source version on businesswire.com: https://www.businesswire.com/news/home/20241111107317/en/\nContacts\nMedia Katie Beach OltsikInizio Evoke Comms(937) 232-4889Katherine.Beach@inizioevoke.com media@sprucebio.com\nInvestors Samir GharibPresident and CFOSpruce Biosciences, Inc.investors@sprucebio.com","kind":null,"is_publish_news":true,"is_publish_highlight":false,"is_publish_live":false,"is_publish_wemedia":null,"editions":null,"column":"","sentiment":"1","news_tag":"","news_rank":0,"symbols":[],"gpt_button":1},"commentList":[],"isCommentEnd":true,"newsSizeData":{"likeSize":0,"commentSize":0,"repostSize":0,"favoriteSize":0,"likeStatus":false,"favoriteStatus":false},"APP":{"userAgent":"Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; 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