Atara Biotherapeutics Announces Third Quarter 2024 Financial Results and Operational Progress

Business Wire11-13 05:01

Tab-cel® U.S. BLA On-Track With PDUFA Target Action Date of January 15, 2025 First Patient Dosed for ATA3219 Non-Hodgkin’s Lymphoma Study; Initial Clinical Data Expected Q1 2025 ATA3219 Lupus ...

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Initial Clinical Data Expected Q1 2025\nATA3219 Lupus ...</p>\n\n<a href=\"https://finance.yahoo.com/news/atara-biotherapeutics-announces-third-quarter-210100338.html\">Source Link</a>\n\n</div>\n\n\n</article>\n</div>\n</body>\n</html>\n","isBrief":false,"type":0,"news_type":1,"symbol":"LD","symbol_name":"iPath Bloomberg Lead Subindex Total Return ETN","start_time":0,"source_url":"https://finance.yahoo.com/news/atara-biotherapeutics-announces-third-quarter-210100338.html","article_id":"2483068688","we_media_id":null,"thumbnails":["https://s.yimg.com/uu/api/res/1.2/9vStvTi0yAA4kId51jmiow--~B/aD0zMjg7dz00ODA7YXBwaWQ9eXRhY2h5b24-/https://media.zenfs.com/en/business-wire.com/e843cb1beb7af9a7bd4239eaafb1f2e2"],"rights":null,"url":"https://stock-news.laohu8.com/highlight/detail?id=2483068688","pubTimestamp":1731445260,"sourceInfo":{"source_id":"yahoofinance","name":"雅虎金融"},"weMediaInfo":null,"summary":"Tab-cel U.S. BLA On-Track With PDUFA Target Action Date of January 15, 2025. First Patient Dosed for ATA3219 Non-Hodgkin’s Lymphoma Study; Initial Clinical Data Expected Q1 2025. ATA3219 Lupus Nephritis and Extrarenal Systemic Lupus Erythematosus Study Initiation Expected by End of Year; Initial Clinical Data Expected Mid-2025. Cash Runway Into 2027 Enables Key Pipeline Readouts. \"With the first patient now enrolled in our Phase 1 NHL trial of ATA3219, we have taken an important step in applying our proven Epstein-Barr virus platform to the significant opportunity in allogeneic CAR T,\" said Cokey Nguyen, Ph.D., President and Chief Executive Officer of Atara. \"The first quarter of 2025 is positioned to be transformational for the company, with the potential for FDA approval of tab-cel and transition of this business to our partner Pierre Fabre, repositioning Atara as a fully focused allogeneic CAR-T company with multiple near-term data milestones for our lead program in oncology and aut","collect":0,"end_time":0,"defaultTopTitle":"yahoo.com","property":[],"viewcount":null,"language":"en","relate_stocks":{"LD":"iPath Bloomberg Lead Subindex Total Return ETN","ATRA":"Atara Biotherapeutics","BK4022":"陆运","CAR":"安飞士","BK4097":"系统软件","BK4230":"旅客陆运","BK4077":"互动媒体与服务","BK4139":"生物科技","LU2065732104.USD":"ALLSPRING (LUX) WF GLOBAL SMALL CAP EQUITY \"I\" (USD) ACC","PRGS":"Progress Software Corporation","SLE":"Super League Gaming Inc."},"translate_title":"Atara Biotherapeutics公布2024年第三季度财务业绩和运营进展","themeId":null,"isJumpTheme":false,"ttsUrl":null,"symbols_score_info":{"ATRA":1,"CAR":1,"LD":1,"PRGS":1,"SLE":1},"content_text":"Tab-cel® U.S. BLA On-Track With PDUFA Target Action Date of January 15, 2025\nFirst Patient Dosed for ATA3219 Non-Hodgkin’s Lymphoma Study; Initial Clinical Data Expected Q1 2025\nATA3219 Lupus Nephritis and Extrarenal Systemic Lupus Erythematosus Study Initiation Expected by End of Year; Initial Clinical Data Expected Mid-2025\nCash Runway Into 2027 Enables Key Pipeline Readouts\nTHOUSAND OAKS, Calif., November 12, 2024--(BUSINESS WIRE)--Atara Biotherapeutics, Inc. (Nasdaq: ATRA), a leader in T-cell immunotherapy, leveraging its novel allogeneic Epstein-Barr virus (EBV) T-cell platform to develop transformative therapies for patients with cancer and autoimmune diseases, today reported financial results for the third quarter 2024, recent business highlights, and key upcoming milestones.\n\"With the first patient now enrolled in our Phase 1 NHL trial of ATA3219, we have taken an important step in applying our proven Epstein-Barr virus platform to the significant opportunity in allogeneic CAR T,\" said Cokey Nguyen, Ph.D., President and Chief Executive Officer of Atara. \"The first quarter of 2025 is positioned to be transformational for the company, with the potential for FDA approval of tab-cel and transition of this business to our partner Pierre Fabre, repositioning Atara as a fully focused allogeneic CAR-T company with multiple near-term data milestones for our lead program in oncology and autoimmune indications.\"\nTabelecleucel (tab-cel® or EbvalloTM) for Post-Transplant Lymphoproliferative Disease (PTLD)\n\nTab-cel biologics license application (BLA) is on track with Priority Review and a Prescription Drug User Fee Act (PDUFA) target action date of January 15, 2025\nA U.S. Food and Drug Administration (FDA) advisory committee meeting is not planned\nAtara has the potential to receive an additional $60 million milestone payment from Pierre Fabre contingent upon FDA approval of the tab-cel BLA\n\nATA3219: CD19 Program in Non-Hodgkin’s Lymphoma (NHL)\n\nFirst patient treated in ongoing Phase 1 clinical study of ATA3219 for NHL, including large B-cell lymphomas, follicular lymphoma, and mantle cell lymphoma\nStudy designed to evaluate safety, preliminary efficacy, pharmacokinetics, and biomarkers\nInitial clinical data anticipated in Q1 2025\n\nATA3219: CD19 Program in Lupus Nephritis (LN)\n\nAtara expects to initiate a Phase 1 study of ATA3219 as a monotherapy for the treatment of systemic lupus erythematosus (SLE) with kidney involvement (lupus nephritis [LN]) by end of year with initial clinical data anticipated in mid-2025\n\nATA3219: CD19 Program in Extrarenal Systemic Lupus Erythematosus (ERL) Without Lymphodepletion (LD)\n\nAtara expanded the Phase 1 LN study of ATA3219 with an additional cohort in ERL without LD, and expects initiation by end of year with initial clinical data anticipated in mid-2025\nThe elimination of LD is designed to further simplify the treatment regimen and to potentially provide a differentiated safety profile to patients without comprising efficacy, which may improve patient access\n\nATA3431: CD19/CD20 Program for B-Cell Malignancies\n\nAtara is progressing toward an IND submission in Q4 2025\n\nLeadership and Board of Directors Update\n\nAs previously announced, on September 9, 2024, Cokey Nguyen, Ph.D. became President and CEO and Pascal Touchon assumed the role of Chairman of the Board of Directors\nGreg Ciongoli, founder and managing partner of Adiumentum Capital Management, joined Atara’s Board of Directors\nEric Hyllengren has been appointed to serve as the Company’s Chief Operating Officer, in addition to his role as Chief Financial Officer\n\nThird Quarter 2024 Financial Results\n\nCash, cash equivalents and short-term investments as of September 30, 2024 totaled $67.2 million, as compared to $35.3 million as of June 30, 2024. This includes a $20 million milestone payment related to the tab-cel BLA acceptance that was received from Pierre Fabre in August 2024, $15.5 million from Pierre Fabre for the purchase of certain existing tab-cel intermediate inventory in September 2024, and gross proceeds of $36 million from a registered direct offering completed in September 2024. The financing was led by existing top institutional investors with participation from a new strategic investor and was completed at a 15% premium to Atara’s 7-day volume-weighted average price\nNet cash used in operating activities was $4.0 million for the third quarter 2024, as compared to $51.3 million in the same period in 2023\n  \nQ3 2024 net cash used in operating activities included a $6.0 million sub-licensing fee payment, which was paid to Memorial Sloan Kettering Cancer Center (MSK) under protest, as Atara does not believe it owes this under the terms of its license agreements with MSK. Atara is entering into evaluative non-binding mediation to potentially resolve this disagreement\n\nTotal revenues were $40.2 million for the third quarter 2024, as compared to $2.1 million for the same period in 2023. Total revenues increased by $38.1 million year over year, primarily due to revenue recognized as a result of additional obligations for the expanded partnership with Pierre Fabre and accelerated recognition of existing deferred revenue due to the planned transition of substantially all activities relating to tab-cel at the time of BLA approval and transfer to Pierre Fabre\nTotal costs and operating expenses include non-cash stock-based compensation, depreciation and amortization expenses of $7.7 million for the third quarter 2024, as compared to $12.4 million for the same period in 2023\nResearch and development expenses were $43.9 million for the third quarter 2024, as compared to $56.9 million for the same period in 2023\n  \nResearch and development expenses include a $6.0 million sub-licensing fee, which was paid to MSK under protest, whereas third quarter 2023 had no such comparable expense\nResearch and development expenses also include $2.9 million of non-cash stock-based compensation expenses for the third quarter 2024, as compared to $6.8 million for the same period in 2023\n\nGeneral and administrative expenses were $10.4 million for the third quarter 2024, as compared to $12.2 million for the same period in 2023\n  \nGeneral and administrative expenses include $3.5 million of non-cash stock-based compensation expenses for the third quarter 2024, as compared to $4.4 million for the same period in 2023\n\nAtara reported net losses of $21.9 million, or $2.93 per share, for the third quarter 2024, as compared to $69.8 million, or $16.40 per share, for the same period in 2023\n\n2024 Outlook and Cash Runway\n\nAtara expects full year 2024 operating expenses to decrease by approximately 35% from 2023\nThe large majority of the year-over-year operating expense reduction began in Q2 2024 and is expected to continue for the remainder of the year\nAtara expects that cash, cash equivalents, short-term investments, and accounts receivable as of September 30, 2024, plus the items noted below, in total will enable funding of planned operations into 2027:\n  \nadditional $60 million approval milestone from Pierre Fabre contingent upon the approval of the tab-cel BLA;\nadditional anticipated purchases of tab-cel inventory through the manufacturing transfer date by Pierre Fabre;\nanticipated reimbursement for tab-cel global development costs through the BLA transfer by Pierre Fabre;\noperating efficiencies resulting from completed workforce reductions;\nthe planned transition of substantially all activities relating to tab-cel at the time of the BLA transfer to Pierre Fabre potentially as early as Q1 2025, which will further reduce quarterly operating expenses; and\nanticipated royalties from sales of tab-cel by Pierre Fabre in the U.S. post BLA approval\n\n\nAbout ATA3219\nATA3219 combines the natural biology of unedited T cells with the benefits of an allogeneic therapy. It consists of allogeneic Epstein-Barr virus (EBV)-sensitized T cells that express a CD19 CAR construct for the treatment of CD19+ relapsed or refractory B-cell malignancies, including B-cell non-Hodgkin’s lymphoma and B-cell mediated autoimmune diseases including systemic lupus erythematosus. ATA3219 has been optimized to offer a potential best-in-class profile, featuring off-the-shelf availability. It incorporates multiple clinically validated technologies including a modified CD3ζ signaling domain (1XX) that optimizes expansion and mitigates exhaustion, enrichment during manufacturing for a less differentiated phenotype for robust expansion and persistence and retains the endogenous T-cell receptor without gene editing as a key survival signal for T cells contributing to persistence.\nAbout ATA3431\nATA3431 is an allogeneic, bispecific CAR directed against CD20 and CD19, built on Atara’s EBV T-cell platform. The design consists of a tandem CD20-CD19 design, with binders oriented to optimize potency. Dual targets address the limitations of single antigen loss and tumor variability. ATA3431 features a novel 1XX signaling domain, memory phenotype, and retained, unedited T-cell receptor. Preclinical data have demonstrated early evidence of antitumor activity, long-term persistence, and superior tumor growth inhibition compared to an autologous CD19/CD20 CAR T benchmark.\nNext-Generation Allogeneic CAR T Approach\nAtara is focused on applying Epstein-Barr virus (EBV) T-cell biology, featuring experience in over 600 patients treated with allogeneic EBV T cells, and novel chimeric antigen receptor (CAR) technologies to meet the current limitations of autologous and allogeneic CAR therapies head-on by advancing a potential best-in-class CAR T pipeline in oncology and autoimmune disease. Unlike gene-edited approaches aimed at inactivating T-cell receptor (TCR) function to reduce the risk for graft-vs-host disease, Atara’s allogeneic platform maintains expression of the native EBV TCR that promotes in vivo functional persistence while also demonstrating inherently low alloreactivity due to their recognition of defined viral antigens and partial human leukocyte antigen (HLA) matching. A molecular toolkit of clinically-validated technologies—including the 1XX signaling domain designed for better cell fitness and less exhaustion while maintaining stemness—offers a differentiated approach to addressing significant unmet need with the next generation CAR T.\nAbout Atara Biotherapeutics, Inc.\nAtara is harnessing the natural power of the immune system to develop off-the-shelf cell therapies for difficult-to-treat cancers and autoimmune conditions that can be rapidly delivered to patients from inventory. With cutting-edge science and differentiated approach, Atara is the first company in the world to receive regulatory approval of an allogeneic T-cell immunotherapy. Our advanced and versatile T-cell platform does not require T-cell receptor or HLA gene editing and forms the basis of a diverse portfolio of investigational therapies that target EBV, the root cause of certain diseases, in addition to next-generation AlloCAR-Ts designed for best-in-class opportunities across a broad range of hematological malignancies and B-cell driven autoimmune diseases. Atara is headquartered in Southern California. For more information, visit atarabio.com and follow @Atarabio on X and LinkedIn.\nForward-Looking Statements\nThis press release contains or may imply \"forward-looking statements\" within the meaning of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934. For example, forward-looking statements include statements regarding: (1) the development, timing and progress of tab-cel®, including the BLA and potential indications, the potential characteristics and benefits of tab-cel®, and the progress and results of, and prospects for, the global partnership with Pierre Fabre Laboratories involving tab-cel®, and the potential financial benefits to Atara as a result of the global partnership with Pierre Fabre Laboratories, including the receipt, timing and amount of any payments to be received by Atara thereunder; (2) the development, timing and progress of Atara’s AlloCAR-T programs (including ATA3219 and ATA3431), including the timing of the start of any clinical trials, the timing of the availability of data from such clinical trials, the timing of submissions of regulatory applications, and the potential benefits, characteristics, safety and efficacy of such product candidates or product candidates emerging from such programs; (3) Atara’s cash runway, the timing and receipt of potential milestone and other payments, and operating expenses, including Atara’s ability to fund its planned operations into 2027; and (4) Atara’s planned transition of substantially all activities relating to tab-cel at the time of the BLA transfer to Pierre Fabre and the timing thereof. Because such statements deal with future events and are based on Atara’s current expectations, they are subject to various risks and uncertainties and actual results, performance or achievements of Atara could differ materially from those described in or implied by the statements in this press release. These forward-looking statements are subject to risks and uncertainties, including, without limitation, risks and uncertainties associated with the costly and time-consuming pharmaceutical product development process and the uncertainty of clinical success; the COVID-19 pandemic and the wars in Ukraine and the Middle East, which may significantly impact (i) our business, research, clinical development plans and operations, including our operations in Southern California and Denver and at our clinical trial sites, as well as the business or operations of our third-party manufacturer, contract research organizations or other third parties with whom we conduct business, (ii) our ability to access capital, and (iii) the value of our common stock; the sufficiency of Atara’s cash resources and need for additional capital; and other risks and uncertainties affecting Atara’s and its development programs, including those discussed in Atara’s filings with the Securities and Exchange Commission , including in the \"Risk Factors\" and \"Management’s Discussion and Analysis of Financial Condition and Results of Operations\" sections of the Company’s most recently filed periodic reports on Form 10-K and Form 10-Q and subsequent filings and in the documents incorporated by reference therein. Except as otherwise required by law, Atara disclaims any intention or obligation to update or revise any forward-looking statements, which speak only as of the date hereof, whether as a result of new information, future events or circumstances or otherwise.\nFinancials\n\n\n\nATARA BIOTHERAPEUTICS, INC.Condensed Consolidated Balance Sheets(Unaudited)(In thousands)\n\n\n\n\n\n\n\n\n\n\n\n\n\nSeptember 30,\n\n\nDecember 31,\n\n\n\n\n\n2024\n\n\n2023\n\n\n\nAssets\n\n\n\n\n\n\n\n\n\n\nCurrent assets:\n\n\n\n\n\n\n\n\n\n\nCash and cash equivalents\n\n$\n46,453\n\n\n$\n25,841\n\n\n\nShort-term investments\n\n\n20,736\n\n\n\n25,884\n\n\n\nRestricted cash\n\n\n146\n\n\n\n146\n\n\n\nAccounts receivable\n\n\n1,335\n\n\n\n34,108\n\n\n\nInventories\n\n\n13,980\n\n\n\n9,706\n\n\n\nOther current assets\n\n\n9,205\n\n\n\n6,184\n\n\n\nTotal current assets\n\n\n91,855\n\n\n\n101,869\n\n\n\nProperty and equipment, net\n\n\n1,661\n\n\n\n3,856\n\n\n\nOperating lease assets\n\n\n45,833\n\n\n\n54,935\n\n\n\nOther assets\n\n\n3,357\n\n\n\n4,844\n\n\n\nTotal assets\n\n$\n142,706\n\n\n$\n165,504\n\n\n\n\n\n\n\n\n\n\n\n\n\n\nLiabilities and stockholders’ equity (deficit)\n\n\n\n\n\n\n\n\n\n\nCurrent liabilities:\n\n\n\n\n\n\n\n\n\n\nAccounts payable\n\n$\n2,146\n\n\n$\n3,684\n\n\n\nAccrued compensation\n\n\n7,768\n\n\n\n11,519\n\n\n\nAccrued research and development expenses\n\n\n6,077\n\n\n\n17,364\n\n\n\nDeferred revenue\n\n\n116,344\n\n\n\n77,833\n\n\n\nOther current liabilities\n\n\n23,644\n\n\n\n31,826\n\n\n\nTotal current liabilities\n\n\n155,979\n\n\n\n142,226\n\n\n\nDeferred revenue - long-term\n\n\n470\n\n\n\n37,562\n\n\n\nOperating lease liabilities - long-term\n\n\n35,243\n\n\n\n45,693\n\n\n\nLiability related to the sale of future revenues - long-term\n\n\n37,584\n\n\n\n34,623\n\n\n\nOther long-term liabilities\n\n\n3,969\n\n\n\n4,631\n\n\n\nTotal liabilities\n\n$\n233,245\n\n\n$\n264,735\n\n\n\n\n\n\n\n\n\n\n\n\n\n\nStockholders’ (deficit) equity:\n\n\n\n\n\n\n\n\n\n\nCommon stock\n\n\n1\n\n\n\n—\n\n\n\nAdditional paid-in capital\n\n\n1,951,298\n\n\n\n1,870,123\n\n\n\nAccumulated other comprehensive loss\n\n\n22\n\n\n\n(204\n)\n\n\nAccumulated deficit\n\n\n(2,041,860\n)\n\n\n(1,969,150\n)\n\n\nTotal stockholders’ (deficit) equity\n\n\n(90,539\n)\n\n\n(99,231\n)\n\n\nTotal liabilities and stockholders’ (deficit) equity\n\n$\n142,706\n\n\n$\n165,504\n\n\n\n\n\n\n\n\n\n\n\n \n\n\n\n\n\n\nATARA BIOTHERAPEUTICS, INC.Condensed Consolidated Statements of Operations and Comprehensive Loss(Unaudited)(In thousands, except per share amounts)\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\nThree Months EndedSeptember 30,\n\n\nNine Months EndedSeptember 30,\n\n\n\n\n\n2024\n\n\n2023\n\n\n2024\n\n\n2023\n\n\n\nCommercialization revenue\n\n$\n40,190\n\n\n$\n2,020\n\n\n$\n96,187\n\n\n$\n3,697\n\n\n\nLicense and collaboration revenue\n\n\n—\n\n\n\n118\n\n\n\n—\n\n\n\n624\n\n\n\nTotal revenue\n\n\n40,190\n\n\n\n2,138\n\n\n\n96,187\n\n\n\n4,321\n\n\n\nCosts and operating expenses:\n\n\n\n\n\n\n\n\n\n\n\n\n\n\nCost of commercialization revenue\n\n\n7,602\n\n\n\n2,615\n\n\n\n14,214\n\n\n\n5,726\n\n\n\nResearch and development expenses\n\n\n43,924\n\n\n\n56,888\n\n\n\n122,762\n\n\n\n175,185\n\n\n\nGeneral and administrative expenses\n\n\n10,421\n\n\n\n12,247\n\n\n\n30,446\n\n\n\n39,454\n\n\n\nTotal costs and operating expenses\n\n\n61,947\n\n\n\n71,750\n\n\n\n167,422\n\n\n\n220,365\n\n\n\nLoss from operations\n\n\n(21,757\n)\n\n\n(69,612\n)\n\n\n(71,235\n)\n\n\n(216,044\n)\n\n\nInterest and other income (expense), net\n\n\n(169\n)\n\n\n(204\n)\n\n\n(1,468\n)\n\n\n372\n\n\n\nLoss before provision for (benefit from) income taxes\n\n\n(21,926\n)\n\n\n(69,816\n)\n\n\n(72,703\n)\n\n\n(215,672\n)\n\n\nProvision for (benefit from) income taxes\n\n\n(17\n)\n\n\n(19\n)\n\n\n7\n\n\n\n4\n\n\n\nNet loss\n\n$\n(21,909\n)\n\n$\n(69,797\n)\n\n$\n(72,710\n)\n\n$\n(215,676\n)\n\n\nOther comprehensive gain (loss):\n\n\n\n\n\n\n\n\n\n\n\n\n\n\nUnrealized gain (loss) on available-for-sale securities\n\n\n36\n\n\n\n362\n\n\n\n226\n\n\n\n1,496\n\n\n\nComprehensive loss\n\n$\n(21,873\n)\n\n$\n(69,435\n)\n\n$\n(72,484\n)\n\n$\n(214,180\n)\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\nBasic and diluted net loss per common share\n\n$\n(2.93\n)\n\n$\n(16.40\n)\n\n$\n(11.34\n)\n\n$\n(51.27\n)\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\nBasic and diluted weighted-average shares outstanding\n\n\n7,466\n\n\n\n4,256\n\n\n\n6,414\n\n\n\n4,207\n\n\n\n\nView source version on businesswire.com: https://www.businesswire.com/news/home/20241112342526/en/\nContacts\nInvestor and Media Relations: Jason Awe, Ph.D.Head of Corporate Communications & Investor Relations(805) 217-2287jawe@atarabio.com","kind":null,"is_publish_news":true,"is_publish_highlight":false,"is_publish_live":false,"is_publish_wemedia":null,"editions":null,"column":"","sentiment":"0","news_tag":"","news_rank":0,"symbols":[],"gpt_button":1},"commentList":[],"isCommentEnd":true,"newsSizeData":{"likeSize":0,"commentSize":0,"repostSize":0,"favoriteSize":0,"likeStatus":false,"favoriteStatus":false},"APP":{"userAgent":"Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)","isDev":false,"isTTM":true,"deviceId":"web-server-community-laohu8-v3","version":"4.29.1","shortVersion":"4.29.1","platform":"web","vendor":"web","appName":"ttm","isIOS":false,"isAndroid":false,"isTiger":false,"isTHS":false,"isWeiXin":false,"isWeiXinMini":false,"isWeiBo":false,"isQQ":false,"isBaiduSwan":false,"isBaiduBox":false,"isDingTalk":false,"isToutiao":false,"isOnePlus":false,"isHuaWei":false,"isXiaomi":false,"isXiaomiWebView":false,"isOppo":false,"isVivo":false,"isSamsung":false,"isMobile":false},"href":"/m/news/2483068688"}