Exact Sciences Unveils Data Showing Promise of Multi-Cancer Early Detection at AACR Special Conference on Liquid Biopsy

Business Wire11-14

New evidence shows multi-biomarker class approach improved cancer detection, including in earlier stages when treatment may be more effective Modeling data estimate adding MCED testing to standard-of-...

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color:#2a4b87;}\n.meta .head { display: inline-block; overflow: hidden}\n.head .h-thumb { width: 30px; height: 30px; margin: 0; padding: 0; border-radius: 50%; float: left;}\n.head .h-content { margin: 0; padding: 0 0 0 9px; float: left;}\n.head .h-name {font-size: 13px; color: #eee; margin: 0;}\n.head .h-time {font-size: 11px; color: #7E829C; margin: 0;line-height: 11px;}\n.small {font-size: 12.5px; display: inline-block; transform: scale(0.9); -webkit-transform: scale(0.9); transform-origin: left; -webkit-transform-origin: left;}\n.smaller {font-size: 12.5px; display: inline-block; transform: scale(0.8); -webkit-transform: scale(0.8); transform-origin: left; -webkit-transform-origin: left;}\n.bt-text {font-size: 12px;margin: 1.5em 0 0 0}\n.bt-text p {margin: 0}\n</style>\n</head>\n<body>\n<div class=\"wrapper\">\n<header>\n<h2 class=\"title\">\nExact Sciences Unveils Data Showing Promise of Multi-Cancer Early Detection at AACR Special Conference on Liquid Biopsy\n</h2>\n\n<h4 class=\"meta\">\n\n\n2024-11-14 02:00 GMT+8&nbsp;&nbsp;&nbsp;<a href=https://finance.yahoo.com/news/exact-sciences-unveils-data-showing-180000842.html><strong>Business Wire</strong></a>\n\n\n</h4>\n\n</header>\n<article>\n<div>\n<p>New evidence shows multi-biomarker class approach improved cancer detection, including in earlier stages when treatment may be more effective\nModeling data estimate adding MCED testing to standard-of-...</p>\n\n<a href=\"https://finance.yahoo.com/news/exact-sciences-unveils-data-showing-180000842.html\">Source Link</a>\n\n</div>\n\n\n</article>\n</div>\n</body>\n</html>\n","isBrief":false,"type":0,"news_type":1,"symbol":"LU0266013472.USD","symbol_name":"AXA WF - Framlington Longevity Economy A Cap USD","start_time":0,"source_url":"https://finance.yahoo.com/news/exact-sciences-unveils-data-showing-180000842.html","article_id":"2483309468","we_media_id":null,"thumbnails":["https://s.yimg.com/uu/api/res/1.2/8.Zw_fMFXwE1UmqHc6JYjQ--~B/aD0yNDE7dz00ODA7YXBwaWQ9eXRhY2h5b24-/https://media.zenfs.com/en/business-wire.com/1cba7dc2787dfeff0d9b1e14d28c8883"],"rights":null,"url":"https://stock-news.laohu8.com/highlight/detail?id=2483309468","pubTimestamp":1731520800,"sourceInfo":{"source_id":"yahoofinance","name":"雅虎金融"},"weMediaInfo":null,"summary":"New evidence shows multi-biomarker class approach improved cancer detection, including in earlier stages when treatment may be more effective. Modeling data estimate adding MCED testing to standard-of-care screening could reduce cancer mortality by 17%. New analysis from DETECT-A study supports MCED testing as a complement to current guideline-recommended screening. A new study demonstrates the ability of a multi-biomarker class MCED test to improve early-stage sensitivity by incorporating a DNA mutation reflex approach to methylation and protein  test results. When excluding breast and prostate cancer and at a 98.5% specificity, sensitivity increased by 28% for stage I cancers and 12.5% for early-stage cancers  in a case-control study, underscoring the potential of a three-biomarker class  test to improve the detection of cancer in earlier stages.","collect":0,"end_time":0,"defaultTopTitle":"yahoo.com","property":[],"viewcount":null,"language":"en","relate_stocks":{"LU0266013472.USD":"AXA WF - Framlington Longevity Economy A Cap USD","IE00BD6J9T35.USD":"NEUBERGER BERMAN NEXT GENERATION MOBILITY \"A\" (USD) ACC","BK4585":"ETF&股票定投概念","BK4139":"生物科技","LU1861558580.USD":"日兴方舟颠覆性创新基金B","BK4168":"多种金属与采矿","BK4588":"碎股","LU1861559042.SGD":"日兴方舟颠覆性创新基金B SGD","BK4548":"巴美列捷福持仓","EXAS":"精密科学","MP":"MP Materials Corp."},"translate_title":"Exact Sciences在AACR液体活检特别会议上公布的数据显示了多种癌症早期检测的前景","themeId":null,"isJumpTheme":false,"ttsUrl":null,"symbols_score_info":{"EXAS":1,"MP":1},"content_text":"New evidence shows multi-biomarker class approach improved cancer detection, including in earlier stages when treatment may be more effective\nModeling data estimate adding MCED testing to standard-of-care screening could reduce cancer mortality by 17%\nNew analysis from DETECT-A study supports MCED testing as a complement to current guideline-recommended screening\nMADISON, Wis., November 13, 2024--(BUSINESS WIRE)--Exact Sciences Corp. (NASDAQ: EXAS), a leading provider of cancer screening and diagnostic tests, will present three abstracts highlighting significant advancements in the development of a multi-cancer early detection (MCED) test. The results of a study evaluating a new multi-biomarker class approach showed improved sensitivity for early-stage and overall cancer detection. In addition, new modeling data estimate that adding MCED testing to recommended screening may reduce the incidence of stage IV cancer and, subsequently, cancer mortality over 10 years. Another new analysis from the DETECT-A study suggests that adding MCED testing complements guideline-recommended lung cancer screening without affecting adherence to current standard of care. These findings will be presented at the American Association for Cancer Research (AACR) Special Conference in Cancer Research: Liquid Biopsy from November 13-16, 2024, in San Diego, Calif.\n\"Cancer is on pace to be the leading cause of death in the U.S. by 20301. Currently, only an estimated 14% of all cancers in the U.S. are diagnosed through screening,2 revealing a glaring gap in patient care,\" said Tom Beer, M.D., chief medical officer and vice president, multi-cancer early detection, Exact Sciences. \"We believe MCED testing is our single biggest opportunity to combat these stark statistics, and the Exact Sciences team is committed to taking a rigorous, comprehensive approach to multi-cancer screening. The new data answer key questions about the impact we can anticipate with MCED testing if integrated into clinical practice.\"\nA new study demonstrates the ability of a multi-biomarker class MCED test to improve early-stage sensitivity by incorporating a DNA mutation reflex approach to methylation and protein (MP) test results. When excluding breast and prostate cancer and at a 98.5% specificity, sensitivity increased by 28% for stage I cancers and 12.5% for early-stage cancers (stages I and II) in a case-control study, underscoring the potential of a three-biomarker class (DNA methylation, protein, DNA mutation reflex, or MP-r) test to improve the detection of cancer in earlier stages.\n\n\n\nCancer stage\nMP-r sensitivity\nMP sensitivity\n% improvement\n\n\nStage I\n22.1%\n17.2%\n28.0%\n\n\nStage II\n54.7%\n51.9%\n5.5%\n\n\nStage I/II\n35.9%\n31.9%\n12.5%\n\n\nOverall\n62.3%\n59.3%\n5.0%\n\n\n\nThis new research will help inform the final design of Exact Sciences’ Cancerguard™ test, which is currently in development and intends to harness the additive sensitivity of multiple biomarker classes to detect more cancers in earlier stages.\nThe abstracts featured at the AACR Special Conference: Liquid Biopsy 2024 are as follows:\nTitle: Performance of multi-biomarker class reflex testing in a prospectively-collected cohortPoster session: Thursday, November 14, 5:15 – 7:15 p.m. PT (Session A)Poster number: A056Key findings: A new analysis from a case-control study demonstrated the ability of a three-biomarker class (DNA methylation, protein, DNA mutation reflex, or MP-r) MCED test approach to increase sensitivity for early-stage detection. When excluding breast and prostate cancer, stage I sensitivity increased by 28%, and stage I/II increased by 12.5%.\nTitle: The potential of multi-cancer early detection screening for reducing cancer mortalityOral presentation: Friday, November 15, 9:35 a.m. PT (Plenary Session 4: Early Detection of Primary Cancer and Relapse)Presenter: Tyson, CPoster number: PR006, A073Key findings: New modeling points to the potential to reduce the burden of cancer by demonstrating an estimated 42% reduction in stage IV cancer incidence and a 17% estimated 10-year reduction in cancer mortality with the addition of MCED testing to usual care.\nTitle: Lung cancer screening adherence among participants in DETECT-A, the first prospective interventional trial of a multi-cancer early detection (MCED) blood testPoster session: Thursday, November 14, 5:15 – 7:15 p.m. PT (Session A)Poster number: A064Key findings: Analysis from the prospective, interventional DETECT-A study showed lung cancer screening adherence was not reduced in participants who received an MCED test compared to controls.\nAbout the DETECT-A study\nThe DETECT-A (Detecting cancers Early Through Elective mutation-based blood Collection and Testing) study was the first-ever large, prospective, interventional study to use a blood test to detect multiple types of cancer in a real-world setting. The DETECT-A study enrolled more than 10,000 women with no history of cancer to determine if a blood test in combination with standard-of-care screenings could detect cancers before signs and symptoms appeared. The CancerSEEK test, the MCED test studied in DETECT-A, was the forerunner to the Cancerguard test, the MCED test currently in development at Exact Sciences.\nAbout the Cancerguard™ test\nThe Cancerguard test, currently in development, is designed to detect multiple cancers in their earliest stages from a single blood draw. Building upon decades of research, Exact Sciences intends to harness the additive sensitivity of multiple biomarker classes to detect more cancers in earlier stages. The Cancerguard test will utilize a streamlined and standardized imaging-based diagnostic pathway, which may result in fewer follow-up procedures. The test is being developed to provide high specificity to help minimize false positives while detecting multiple cancers, including those with the biggest toll on human health. These features describe current development goals. The Cancerguard test has not been cleared or approved by the U.S. Food and Drug Administration or any other national regulatory authority. To learn more, visit http://www.exactsciences.com/cancerguard.\nAbout Exact Sciences Corp.\nA leading provider of cancer screening and diagnostic tests, Exact Sciences gives patients and health care professionals the clarity needed to take life-changing action earlier. Building on the success of the Cologuard® and Oncotype® tests, Exact Sciences is investing in its pipeline to develop innovative solutions for use before, during, and after a cancer diagnosis. For more information, visit ExactSciences.com, follow Exact Sciences on X (formerly known as Twitter) @ExactSciences, or find Exact Sciences on LinkedIn and Facebook.\nForward-Looking Statement\nThis news release contains forward-looking statements concerning our expectations, anticipations, intentions, beliefs, or strategies regarding the future. These forward-looking statements are based on assumptions that we have made as of the date hereof and are subject to known and unknown risks and uncertainties that could cause actual results, conditions, and events to differ materially from those anticipated. Therefore, you should not place undue reliance on forward-looking statements. Examples of forward-looking statements include, among others, statements we make regarding the development and commercialization of the Cancerguard test, and the performance characteristics and healthcare benefits of the Cancerguard test. Risks and uncertainties that may affect our forward-looking statements are described in the Risk Factors sections of our most recent Annual Report on Form 10-K and any subsequent Quarterly Reports on Form 10-Q, and in our other reports filed with the Securities and Exchange Commission. We undertake no obligation to publicly update any forward-looking statement, whether written or oral, that may be made from time to time, whether as a result of new information, future developments or otherwise.\nReferences:\n\nCDC Archive. Future Health of our Nation Infographic. Accessed July 12, 2024.\nNORC at the University of Chicago. New Research Highlights Just One In Seven Diagnosed Cancers Found By A Recommended Screening Test. Accessed October 31, 2024. Limitations: Based on modeling data derived from numerous sources including self-reported surveys. Includes assumptions on detectability of certain cancer types. Does not include all cancer types or screening methods. \n\nView source version on businesswire.com: https://www.businesswire.com/news/home/20241113756824/en/\nContacts\nExact SciencesMedia Contact: Allison Barry, abarry@exactsciences.com, 980.297.1957Investor Contact: Erik Holznecht, investorrelations@exactsciences.com, 608.800.6605","kind":null,"is_publish_news":true,"is_publish_highlight":false,"is_publish_live":false,"is_publish_wemedia":null,"editions":null,"column":"","sentiment":"1","news_tag":"Product Release","news_rank":0,"symbols":[],"gpt_button":0},"commentList":[],"isCommentEnd":true,"newsSizeData":{"likeSize":0,"commentSize":0,"repostSize":0,"favoriteSize":0,"likeStatus":false,"favoriteStatus":false},"APP":{"userAgent":"Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)","isDev":false,"isTTM":true,"deviceId":"web-server-community-laohu8-v3","version":"4.29.2","shortVersion":"4.29.2","platform":"web","vendor":"web","appName":"ttm","isIOS":false,"isAndroid":false,"isTiger":false,"isTHS":false,"isWeiXin":false,"isWeiXinMini":false,"isWeiBo":false,"isQQ":false,"isBaiduSwan":false,"isBaiduBox":false,"isDingTalk":false,"isToutiao":false,"isOnePlus":false,"isHuaWei":false,"isXiaomi":false,"isXiaomiWebView":false,"isOppo":false,"isVivo":false,"isSamsung":false,"isMobile":false},"href":"/m/news/2483309468"}