PolyPid Provides Corporate Update and Reports Third Quarter 2024 Financial Results

GlobeNewswire11-13

Last Patient Enrolled for Planned Unblinded Interim Analysis in Ongoing SHIELD II Phase 3 Trial of D-PLEX100 Unblinded Interim Analysis Outcome Expected Later this Quarter SHIELD II Enrollment ...

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overflow: hidden}\n.head .h-thumb { width: 30px; height: 30px; margin: 0; padding: 0; border-radius: 50%; float: left;}\n.head .h-content { margin: 0; padding: 0 0 0 9px; float: left;}\n.head .h-name {font-size: 13px; color: #eee; margin: 0;}\n.head .h-time {font-size: 11px; color: #7E829C; margin: 0;line-height: 11px;}\n.small {font-size: 12.5px; display: inline-block; transform: scale(0.9); -webkit-transform: scale(0.9); transform-origin: left; -webkit-transform-origin: left;}\n.smaller {font-size: 12.5px; display: inline-block; transform: scale(0.8); -webkit-transform: scale(0.8); transform-origin: left; -webkit-transform-origin: left;}\n.bt-text {font-size: 12px;margin: 1.5em 0 0 0}\n.bt-text p {margin: 0}\n</style>\n</head>\n<body>\n<div class=\"wrapper\">\n<header>\n<h2 class=\"title\">\nPolyPid Provides Corporate Update and Reports Third Quarter 2024 Financial Results\n</h2>\n\n<h4 class=\"meta\">\n\n\n2024-11-13 20:00 GMT+8&nbsp;&nbsp;&nbsp;<a href=https://finance.yahoo.com/news/polypid-provides-corporate-reports-third-120000289.html><strong>GlobeNewswire</strong></a>\n\n\n</h4>\n\n</header>\n<article>\n<div>\n<p>Last Patient Enrolled for Planned Unblinded Interim Analysis in Ongoing SHIELD II Phase 3 Trial of D-PLEX100 \n Unblinded Interim Analysis Outcome Expected Later this Quarter\nSHIELD II Enrollment ...</p>\n\n<a href=\"https://finance.yahoo.com/news/polypid-provides-corporate-reports-third-120000289.html\">Source Link</a>\n\n</div>\n\n\n</article>\n</div>\n</body>\n</html>\n","isBrief":false,"type":0,"news_type":1,"symbol":"PYPD","symbol_name":"PolyPid Ltd.","start_time":0,"source_url":"https://finance.yahoo.com/news/polypid-provides-corporate-reports-third-120000289.html","article_id":"2483900617","we_media_id":null,"thumbnails":["https://s.yimg.com/uu/api/res/1.2/reEHAAw2X6GDWtgzw.4r1Q--~B/aD0zNjU7dz0zOTU7YXBwaWQ9eXRhY2h5b24-/https://media.zenfs.com/en/globenewswire.com/a8ff8dfae793300132d18fd5863b278b"],"rights":null,"url":"https://stock-news.laohu8.com/highlight/detail?id=2483900617","pubTimestamp":1731499200,"columns":[],"sourceInfo":{"source_id":"yahoofinance","name":"雅虎金融"},"weMediaInfo":null,"summary":"Last Patient Enrolled for Planned Unblinded Interim Analysisin Ongoing SHIELD II Phase 3 Trial ofD-PLEX100. SHIELD II Enrollment Completion Expected in December 2024 with Top-Line Results Anticipated in First Quarter of 2025. PETACH TIKVA,Israel, Nov. 13, 2024  -- PolyPid Ltd. , a late-stage biopharma company aiming to improve surgical outcomes, today provided a corporate update and reported financial results for the three and nine months ended September 30, 2024.Recently enrolled the last patient required  to conduct the planned unblinded interim analysis, which will occur during the current quarter, now that the 30-day follow-up assessment for the last patient has been completed. The unblinded interim analysis will lead to one of the following outcomes: early trial conclusion due to positive efficacy, continuation to planned patient recruitment , sample size re-assessment, or futility.“We are very encouraged by the recent significant acceleration in patient enrollment due to the open","collect":0,"end_time":0,"defaultTopTitle":"yahoo.com","property":[],"viewcount":null,"language":"en","relate_stocks":{"PYPD":"PolyPid Ltd.","BK4007":"制药"},"translate_title":"PolyPid提供公司最新动态并报告2024年第三季度财务业绩","themeId":null,"isJumpTheme":false,"ttsUrl":null,"symbols_score_info":{"PYPD":1},"content_text":"Last Patient Enrolled for Planned Unblinded Interim Analysis in Ongoing SHIELD II Phase 3 Trial of D-PLEX100 \n Unblinded Interim Analysis Outcome Expected Later this Quarter\nSHIELD II Enrollment Completion Expected in December 2024 with Top-Line Results Anticipated in First Quarter of 2025\nConference Call Scheduled for Today at 8:30 AM ET\nPETACH TIKVA, Israel, Nov. 13, 2024 (GLOBE NEWSWIRE) -- PolyPid Ltd. (Nasdaq: PYPD) (“PolyPid” or the “Company”), a late-stage biopharma company aiming to improve surgical outcomes, today provided a corporate update and reported financial results for the three and nine months ended September 30, 2024.\nRecent Corporate Highlights:\n\nOver 540 patients have been enrolled to date in the ongoing SHIELD II Phase 3 trial of D-PLEX100 for the prevention of abdominal colorectal surgical site infections (SSIs).\n\nRecently enrolled the last patient required (430 subjects) to conduct the planned unblinded interim analysis, which will occur during the current quarter, now that the 30-day follow-up assessment for the last patient has been completed. The unblinded interim analysis will lead to one of the following outcomes: early trial conclusion due to positive efficacy, continuation to planned patient recruitment (up to 630 subjects), sample size re-assessment, or futility.\nApproximately 60 centers are currently open in multiple countries, including in Eastern Europe, the U.S., Germany, Ireland, Portugal and Israel.\nEnrollment completion of up to 630 patients is expected in December 2024 and top-line results anticipated in the first quarter of 2025.\n \nResults from the Phase 3 SHIELD I trial, one of the largest Phase 3 studies in the prevention of SSIs in colorectal resection conducted in over a decade, were published in the International Journal of Surgery; manuscript available here. Key results:\n\nA statistically significant reduction of the primary endpoint (a composite of incisional SSI, incisional reinterventions due to poor wound healing, or all-cause mortality) was observed in D-PLEX100 treated patients in a pre-specified analysis of the subpopulation with large surgical incisions (greater than 20 cm; p=0.0032).\nAnalysis of the key secondary efficacy outcome, incisional SSI, also indicated a 54.6% reduction in the large surgical incision subgroup (4.4% in D-PLEX100 vs. 9.7% in standard of care (SoC), p= 0.0410).\nBased on the statistically significant reduction of the primary endpoint in the prespecified subgroup demonstrated in SHIELD I, and following the FDA guidance, the ongoing Phase 3 SHIELD II study focuses on patients with large surgical incisions. \n \n\n“We are very encouraged by the recent significant acceleration in patient enrollment due to the opening of all 60 planned centers in the study and the increase in the volume of surgical procedures following the conclusion of the slower summer months,” stated Dikla Czaczkes Akselbrad, PolyPid’s Chief Executive Officer. “With more than 540 patients enrolled to date in SHIELD II, we look forward to the upcoming interim analysis later this quarter. Importantly, we are funded beyond this key data catalyst and, if all the warrants issued in both of our most recent private placement financings are exercised, we would be funded into 2026.”\nFinancial results for three months ended September 30, 2024\n\nResearch and development (R&D) expenses for the three months ended September 30, 2024, were $6.0 million, compared to $3.8 million in the same three-month period of 2023. The increase in R&D expenses was driven by the ramp up in patient enrollment in the SHIELD II Phase 3 trial.\nGeneral and administrative (G&A) expenses for the three months ended September 30, 2024, were $1.2 million, similar to the same period of 2023.\nMarketing and business development expenses for the three months ended September 30, 2024, were $0.2 million, compared to $0.3 million for the same period of 2023.\nFor the three months ended September 30, 2024, the Company had a net loss of $7.8 million, or ($1.22) per share, compared to a net loss of $5.6 million, or ($3.40) per share, in the three-month period ended September 30, 2023.    \n\nFinancial results for nine months ended September 30, 2024\n\nR&D expenses, net for the nine months ended September 30, 2024, were $15.8 million, compared to $11.6 million for the same nine-month period of 2023. The increase in R&D expenses was driven by the ramp up in patient enrollment in the SHIELD II Phase 3 trial.\nG&A expenses for the nine months ended September 30, 2024, were $3.3 million, compared to $4.3 million for the same period of 2023.\nMarketing and business development expenses for the nine months ended September 30, 2024, were $0.7 million, compared to $1.0 million for the same period of 2023.\nThe decreases in G&A and marketing and business development expenses were primarily due to the Company’s ongoing cost savings initiatives. \nFor the nine months ended September 30, 2024, the Company had a net loss of $20.5 million, or ($3.82) per share, compared to a net loss of $17.5 million, or ($13.59) per share, in the nine-month period ended September 30, 2023.    \n\nBalance Sheet Highlights\n\nAs of September 30, 2024, the Company had cash, cash equivalents, and short-term deposits in the amount of $9.5 million, compared to $5.3 million on December 31, 2023. PolyPid expects that its current cash balance will be sufficient to fund operations into the first quarter of 2025. If all warrants issued in both of the Company’s most recent private placement financings are exercised, the Company would be funded into 2026.\n\nConference Call Dial-In & Webcast Information:\n\n\n\n \nDate: \nWednesday, November 13, 2024\n\n\n \nTime:\n8:30 AM Eastern Time\n\n\n \nConference Call:\nhttps://register.vevent.com/register/BI198de55d5c06495994d35cbb213655eb\n\n\n \nWebcast:\nhttps://edge.media-server.com/mmc/p/j6bnvt8c\n\n\n\nAbout SHIELD II\nSHIELD II (Surgical site Hospital acquired Infection prEvention with Local D-PLEX) is a prospective, multinational, randomized, double blind Phase 3 trial designed to assess the efficacy and safety of D-PLEX100 administered concomitantly with standard of care (“SoC”), which includes prophylactic systemic antibiotics, compared to SoC alone arm, in the prevention of post abdominal-surgery incisional infection in patients undergoing abdominal colorectal surgeries with large incisions. The primary endpoint of the trial is measured by the proportion of subjects with either a surgical site infection (“SSI”) event as determined by a blinded and independent adjudication committee, reintervention, or mortality for any reason within 30 days post-surgery. Patient safety will be monitored for an additional 30 days. The trial will enroll patients in centers in the United States, Europe and Israel.\nAbout D-PLEX100\nD-PLEX100, PolyPid’s lead product candidate, is designed to provide local prolonged and controlled anti-bacterial activity directly at the surgical site to prevent SSIs. Following the administration of D-PLEX100 into the surgical site, the PLEX (Polymer-Lipid Encapsulation matriX) technology pairs with Active Pharmaceutical Ingredients, enabling a prolonged and continuous release of the broad-spectrum antibiotic doxycycline, resulting in a high local concentration of the drug for a period of 30 days for the prevention of SSIs, with additional potential to prevent SSIs caused by antibiotic-resistant bacteria at the surgical site. D-PLEX100 received Breakthrough Therapy Designation from the U.S. Food and Drug Administration for the prevention of SSIs in patients undergoing elective colorectal surgery. D-PLEX100 is currently in Phase 3 SHIELD II trial for the prevention of surgical site infections in patients undergoing abdominal colorectal surgery with large incisions.\nAbout PolyPid\nPolyPid Ltd. (Nasdaq: PYPD) is a late-stage biopharma company aiming to improve surgical outcomes. Through locally administered, controlled, prolonged-release therapeutics, PolyPid’s proprietary PLEX (Polymer-Lipid Encapsulation matriX) technology pairs with Active Pharmaceutical Ingredients (APIs), enabling precise delivery of drugs at optimal release rates over durations ranging from several days to months. PolyPid’s lead product candidate D-PLEX100 is in Phase 3 clinical trial for the prevention of abdominal colorectal surgical site infections. In addition, the Company is currently in preclinical stages to test the efficacy of OncoPLEX for the treatment of solid tumors, beginning with glioblastoma.\nFor additional Company information, please visit http://www.polypid.com and follow us on Twitter and LinkedIn.\nForward-looking Statements\nThis press release contains “forward-looking statements” within the meaning of the Private Securities Litigation Reform Act and other securities laws. Words such as “expects,” “anticipates,” “intends,” “plans,” “believes,” “seeks,” “estimates” and similar expressions or variations of such words are intended to identify forward-looking statements. For example, the Company is using forward-looking statements when it discusses the expected enrollment pace, the expected timing for top-line results from the SHIELD II trial and of the unblinded interim analysis, the Company’s expected cash runway and that if all warrants issued in both of Company’s most recent private placement financings are exercised, the Company would be funded into 2026. Forward-looking statements are not historical facts, and are based upon management’s current expectations, beliefs and projections, many of which, by their nature, are inherently uncertain. Such expectations, beliefs and projections are expressed in good faith. However, there can be no assurance that management’s expectations, beliefs and projections will be achieved, and actual results may differ materially from what is expressed in or indicated by the forward-looking statements. Forward-looking statements are subject to risks and uncertainties that could cause actual performance or results to differ materially from those expressed in the forward-looking statements. For a more detailed description of the risks and uncertainties affecting the Company, reference is made to the Company’s reports filed from time to time with the Securities and Exchange Commission, including, but not limited to, the risks detailed in the Company’s Annual Report on Form 20-F filed on March 6, 2024. Forward-looking statements speak only as of the date the statements are made. The Company assumes no obligation to update forward-looking statements to reflect actual results, subsequent events or circumstances, changes in assumptions or changes in other factors affecting forward-looking information except to the extent required by applicable securities laws. If the Company does update one or more forward-looking statements, no inference should be drawn that the Company will make additional updates with respect thereto or with respect to other forward-looking statements.\nReferences and links to websites have been provided as a convenience, and the information contained on such websites is not incorporated by reference into this press release. PolyPid is not responsible for the contents of third-party websites.\nContacts: PolyPid Ltd. Ori WarshavskyCOO – US908-858-5995IR@Polypid.com\nInvestors:Brian RitchieLifeSci Advisors212-915-2578BRitchie@lifesciadvisors.com\n\n\n\nINTERIM CONDENSED CONSOLIDATED BALANCE SHEETS\n\n\nU.S. dollars in thousands\n\n\n \n\n\n \n \nSeptember 30,\n \nDecember 31,\n\n\n \n \n 2024\n \n 2023\n\n\n \n \nUnaudited\n \nAudited\n\n\n \n \n \n \n \n\n\nASSETS\n \n \n \n \n\n\n \n \n \n \n \n\n\nCURRENT ASSETS:\n \n \n \n \n\n\nCash and cash equivalents\n \n$\n4,804\n \n$\n5,309\n\n\nRestricted deposits\n \n \n165\n \n \n300\n\n\nShort-term bank deposits\n \n \n4,728\n \n \n-\n\n\nPrepaid expenses and other current assets\n \n \n750\n \n \n458\n\n\n \n \n \n \n \n\n\nTotal current assets\n \n \n10,447\n \n \n6,067\n\n\n \n \n \n \n \n\n\nLONG-TERM ASSETS:\n \n \n \n \n\n\nProperty and equipment, net\n \n \n6,414\n \n \n7,621\n\n\nOperating lease right-of-use assets\n \n \n2,464\n \n \n1,597\n\n\nOther long-term assets\n \n \n269\n \n \n87\n\n\n \n \n \n \n \n\n\nTotal long-term assets\n \n \n9,147\n \n \n9,305\n\n\n \n \n \n \n \n\n\nTotal assets\n \n$\n19,594\n \n$\n15,372\n\n\n \n\n\n\n\n\n\nINTERIM CONDENSED CONSOLIDATED BALANCE SHEETS\n\n\nU.S. dollars in thousands (except share and per share data)\n\n\n \n\n\n \n \nSeptember 30,\n \nDecember 31,\n\n\n \n \n \n2024\n \n \n \n2023\n \n\n\n \n \nUnaudited\n \nAudited\n\n\n \n \n \n \n \n\n\nLIABILITIES AND SHAREHOLDERS' EQUITY\n \n \n \n \n\n\n \n \n \n \n \n\n\nCURRENT LIABILITIES:\n \n \n \n \n\n\nCurrent maturities of long-term debt\n \n$\n5,178\n \n \n$\n4,003\n \n\n\nAccrued expenses and other current liabilities\n \n \n2,770\n \n \n \n1,971\n \n\n\nTrade payables\n \n \n1,641\n \n \n \n772\n \n\n\nCurrent maturities of operating lease liabilities\n \n \n888\n \n \n \n540\n \n\n\n \n \n \n \n \n\n\nTotal current liabilities\n \n \n10,477\n \n \n \n7,286\n \n\n\n \n \n \n \n \n\n\nLONG-TERM LIABILITIES:\n \n \n \n \n\n\nLong-term debt\n \n \n2,529\n \n \n \n6,379\n \n\n\nDeferred revenues\n \n \n2,548\n \n \n \n2,548\n \n\n\nLong-term operating lease liabilities\n \n \n1,421\n \n \n \n857\n \n\n\nOther liabilities\n \n \n461\n \n \n \n398\n \n\n\n \n \n \n \n \n\n\nTotal long-term liabilities\n \n \n6,959\n \n \n \n10,182\n \n\n\n \n \n \n \n \n\n\nCOMMITMENTS AND CONTINGENT LIABILITIES\n \n \n \n \n\n\n \n \n \n \n \n\n\nSHAREHOLDERS' EQUITY (DEFICIT):\n \n \n \n \n\n\nOrdinary shares with no par value -\n \n \n \n \n \n \n \n \n\n\nAuthorized: 107,800,000 and 107,800,000 shares at September 30, 2024 (unaudited) and \n \n \n \n \n \n \n \n \n\n\nDecember 31, 2023, respectively; Issued and outstanding: 6,803,478 and 1,653,559 shares at September 30, 2024 (unaudited) and December 31, 2023, respectively.\n \n \n- \n \n \n \n- \n \n\n\nAdditional paid-in capital\n \n \n260,969\n \n \n \n236,213\n \n\n\nAccumulated deficit\n \n \n(258,811\n)\n \n \n(238,309\n)\n\n\n \n \n \n \n \n\n\nTotal shareholders' equity (deficit)\n \n \n2,158\n \n \n \n(2,096\n)\n\n\n \n \n \n \n \n\n\nTotal liabilities and shareholders' equity (deficit)\n \n$\n19,594\n \n \n$\n15,372\n \n\n\n \n\n\n\n\n\n\nINTERIM CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS (UNAUDITED)\n\n\nU.S. dollars in thousands (except share and per share data)\n\n\n \n\n\n \n \nNine Months Ended\n \nThree Months Ended\n\n\n \n \nSeptember 30,\n \nSeptember 30,\n\n\n \n \n \n2024\n \n \n2023\n \n \n2024\n \n \n2023\n\n\n \n \n \n \n \n \n \n \n \n\n\nOperating expenses:\n \n \n \n \n \n \n \n \n\n\nResearch and development, net\n \n$\n15,784\n \n$\n11,560\n \n$\n5,974\n \n$\n3,806\n\n\nMarketing and business development\n \n \n747\n \n \n1,003\n \n \n246\n \n \n261\n\n\nGeneral and administrative\n \n \n3,277\n \n \n4,305\n \n \n1,166\n \n \n1,193\n\n\n \n \n \n \n \n \n \n \n \n\n\nOperating loss\n \n \n19,808\n \n \n16,868\n \n \n7,386\n \n \n5,260\n\n\nFinancial expense, net\n \n \n665\n \n \n581\n \n \n354\n \n \n319\n\n\n \n \n \n \n \n \n \n \n \n\n\nLoss before income tax\n \n \n20,473\n \n \n17,449\n \n \n7,740\n \n \n5,579\n\n\nIncome tax expenses\n \n \n29\n \n60\n \n20\n \n25\n\n\n \n \n \n \n \n \n\n\nNet loss\n \n$\n20,502\n$\n17,509\n$\n7,760\n$\n5,604\n\n\n \n \n \n \n \n \n\n\nBasic and diluted loss per ordinary share\n$\n        3.82\n \n$\n        13.59\n \n$\n1.22\n \n$\n3.40\n\n\n \n \n \n \n \n \n \n \n \n\n\nWeighted average number of ordinary \n \n \n\n\nshares used in computing basic and \n \n \n\n\ndiluted loss per share\n \n \n5,362,858\n \n \n1,288,678\n \n \n6,361,286\n \n \n1,650,259","kind":"highlight","is_publish_news":true,"is_publish_highlight":false,"is_publish_live":false,"is_publish_wemedia":null,"editions":null,"column":"","sentiment":"0","news_tag":"","news_rank":0,"symbols":[],"gpt_button":1},"commentList":[],"isCommentEnd":true,"newsSizeData":{"likeSize":0,"commentSize":0,"repostSize":0,"favoriteSize":0,"likeStatus":false,"favoriteStatus":false},"APP":{"userAgent":"Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; 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