Intellia Therapeutics' Gene Therapies Fall Short Of Breakthroughs (Rating Downgrade)

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Intellia initiated the Phase 3 HAELO trial for NTLA-2002, targeting lifelong control of hereditary angioedema (HAE) with a single-dose CRISPR-based therapy.Positive Phase 2 NTLA-2002 data showed most ...

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however, limitations like small sample size and short follow-up require cautious interpretation.Phase 1 data for nexiguran ziclumeran (nex-z) in ATTR amyloidosis showed disease stabilization, but competitive therapies demonstrate more robust improvements.Intellia has strong financial health, with over $900M in liquidity and a cash runway expected to last until late 2026.Intellia's limited transformational data, high manufacturing costs, and competitive landscape justify downgrading the stock from \"Buy\" to \"Hold.\"   Bevan Goldswain  Introduction Intellia Therapeutics (NASDAQ:NTLA) stock is down 52% since I downgraded it from \"strong buy\" to \"buy\" in October 2023. 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