Pharma Stock Roundup: PFE's 2025 Outlook, MRK & ABBV's M&A Deals

Zacks12-20 20:27

This week, Pfizer PFE issued its financial guidance for 2025. Sanofi SNY and Teva Pharmaceutical’s TEVA inflammatory bowel disease (IBD) study on their candidate, duvakitug (TEV’574), met its primary ...

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Sanofi SNY and Teva Pharmaceutical’s TEVA inflammatory bowel disease (IBD) study on their candidate, duvakitug (TEV’574), met its primary ...</p>\n\n<a href=\"https://finance.yahoo.com/news/pharma-stock-roundup-pfes-2025-122700744.html\">Source Link</a>\n\n</div>\n","source":"yahoofinance","html":"<!DOCTYPE html>\n<html>\n<head>\n<meta http-equiv=\"Content-Type\" content=\"text/html; charset=utf-8\" />\n<meta name=\"viewport\" content=\"width=device-width,initial-scale=1.0,minimum-scale=1.0,maximum-scale=1.0,user-scalable=no\"/>\n<meta name=\"format-detection\" content=\"telephone=no,email=no,address=no\" />\n<title>Pharma Stock Roundup: PFE's 2025 Outlook, MRK & ABBV's M&A Deals</title>\n<style type=\"text/css\">\na,abbr,acronym,address,applet,article,aside,audio,b,big,blockquote,body,canvas,caption,center,cite,code,dd,del,details,dfn,div,dl,dt,\nem,embed,fieldset,figcaption,figure,footer,form,h1,h2,h3,h4,h5,h6,header,hgroup,html,i,iframe,img,ins,kbd,label,legend,li,mark,menu,nav,\nobject,ol,output,p,pre,q,ruby,s,samp,section,small,span,strike,strong,sub,summary,sup,table,tbody,td,tfoot,th,thead,time,tr,tt,u,ul,var,video{ font:inherit;margin:0;padding:0;vertical-align:baseline;border:0 }\nbody{ font-size:16px; line-height:1.5; color:#999; background:transparent; }\n.wrapper{ overflow:hidden;word-break:break-all;padding:10px; }\nh1,h2{ font-weight:normal; line-height:1.35; margin-bottom:.6em; }\nh3,h4,h5,h6{ line-height:1.35; margin-bottom:1em; }\nh1{ font-size:24px; }\nh2{ font-size:20px; }\nh3{ font-size:18px; }\nh4{ font-size:16px; }\nh5{ font-size:14px; }\nh6{ font-size:12px; }\np,ul,ol,blockquote,dl,table{ margin:1.2em 0; }\nul,ol{ margin-left:2em; }\nul{ list-style:disc; }\nol{ list-style:decimal; }\nli,li p{ margin:10px 0;}\nimg{ max-width:100%;display:block;margin:0 auto 1em; }\nblockquote{ color:#B5B2B1; border-left:3px solid #aaa; padding:1em; }\nstrong,b{font-weight:bold;}\nem,i{font-style:italic;}\ntable{ width:100%;border-collapse:collapse;border-spacing:1px;margin:1em 0;font-size:.9em; }\nth,td{ padding:5px;text-align:left;border:1px solid #aaa; }\nth{ font-weight:bold;background:#5d5d5d; }\n.symbol-link{font-weight:bold;}\n/* header{ border-bottom:1px solid #494756; } */\n.title{ margin:0 0 8px;line-height:1.3;color:#ddd; }\n.meta {color:#5e5c6d;font-size:13px;margin:0 0 .5em; }\na{text-decoration:none; color:#2a4b87;}\n.meta .head { display: inline-block; overflow: hidden}\n.head .h-thumb { width: 30px; height: 30px; margin: 0; padding: 0; border-radius: 50%; float: left;}\n.head .h-content { margin: 0; padding: 0 0 0 9px; float: left;}\n.head .h-name {font-size: 13px; color: #eee; margin: 0;}\n.head .h-time {font-size: 11px; color: #7E829C; margin: 0;line-height: 11px;}\n.small {font-size: 12.5px; display: inline-block; transform: scale(0.9); -webkit-transform: scale(0.9); transform-origin: left; -webkit-transform-origin: left;}\n.smaller {font-size: 12.5px; display: inline-block; transform: scale(0.8); -webkit-transform: scale(0.8); transform-origin: left; -webkit-transform-origin: left;}\n.bt-text {font-size: 12px;margin: 1.5em 0 0 0}\n.bt-text p {margin: 0}\n</style>\n</head>\n<body>\n<div class=\"wrapper\">\n<header>\n<h2 class=\"title\">\nPharma Stock Roundup: PFE's 2025 Outlook, MRK & ABBV's M&A Deals\n</h2>\n\n<h4 class=\"meta\">\n\n\n2024-12-20 20:27 GMT+8&nbsp;&nbsp;&nbsp;<a href=https://finance.yahoo.com/news/pharma-stock-roundup-pfes-2025-122700744.html><strong>Zacks</strong></a>\n\n\n</h4>\n\n</header>\n<article>\n<div>\n<p>This week, Pfizer PFE issued its financial guidance for 2025. Sanofi SNY and Teva Pharmaceutical’s TEVA inflammatory bowel disease (IBD) study on their candidate, duvakitug (TEV’574), met its primary ...</p>\n\n<a href=\"https://finance.yahoo.com/news/pharma-stock-roundup-pfes-2025-122700744.html\">Source Link</a>\n\n</div>\n\n\n</article>\n</div>\n</body>\n</html>\n","isBrief":false,"type":0,"news_type":1,"symbol":"BK4557","symbol_name":"大麻股","start_time":0,"source_url":"https://finance.yahoo.com/news/pharma-stock-roundup-pfes-2025-122700744.html","article_id":"2492441235","we_media_id":null,"thumbnails":["https://s.yimg.com/uu/api/res/1.2/cJ7Tfg7ljIEMGiDFsviYYw--~B/aD00MDA7dz02MzU7YXBwaWQ9eXRhY2h5b24-/https://media.zenfs.com/en/zacks.com/afe95824683969079aeba27c8210bd37"],"rights":null,"url":"https://stock-news.laohu8.com/highlight/detail?id=2492441235","pubTimestamp":1734697620,"columns":[],"sourceInfo":{"source_id":"yahoofinance","name":"雅虎金融"},"weMediaInfo":null,"summary":"Here's a recap of the week’s most important stories.Pfizer announced encouraging guidance for 2025. In 2025, Pfizer expects to record total revenues between $61.0 billion and $64.0 billion. On an operational basis, revenues in 2025 are expected to rise in a range of approximately flat to 5% from the midpoint of 2024 guidance, excluding the impact of approximately $1.2 billion of non-recurring revenues for Paxlovid.Adjusted earnings are expected in the range of $2.80-$3.00, representing expected operational growth  in the range of 10%-18% year over year from the midpoint of the 2024 guidance, excluding the impact of certain non-recurring items.Merck announced that it is in-licensing exclusive global rights to develop, manufacture and commercializea preclinical GLP-1 receptor agonist, HS-10535, from Chinese biotech Hansoh Pharma. For the exclusive deal, Merck will make an upfront payment of $112 million to Hansoh Pharma, with the latter also being entitled to receive up to $1.9 billion i","collect":0,"end_time":0,"defaultTopTitle":"yahoo.com","property":[],"viewcount":null,"language":"en","relate_stocks":{"BK4557":"大麻股","LU2361044865.SGD":"WELLINGTON US QUALITY GROWTH \"A\" (SGDHDG) ACC","PFE":"辉瑞","LU0006306889.USD":"SCHRODER ISF US LARGE CAP \"A\" (USD) INC AV","LU0795875086.SGD":"JPMorgan Investment Funds - Global Income A (div) SGD","LU2087621335.USD":"ALLSPRING GLOBAL FACTOR ENHANCED EQUITY \"A\" (USD) ACC","CHMP":"冠军工业","MRK":"默沙东","BK4550":"红杉资本持仓","LU2361045086.USD":"WELLINGTON US QUALITY GROWTH \"A\" (USD) ACC","IE000M9KFDE8.USD":"NEUBERGER BERMAN US LARGE CAP VALUE \"A\" (USD) ACC","IE00BVYPNV92.GBP":"GUINNESS GLOBAL EQUITY INCOME \"C\" (GBP) ACC","CD":"秦淮数据","LU0708994859.HKD":"TEMPLETON GLOBAL \"A\" (HKD) ACC","SNY":"赛诺菲安万特","LU0738911758.USD":"Blackrock Global Equity Income A6 USD","IE00B42XCP33.USD":"GUINNESS GLOBAL EQUITY INCOME \"C\" (USD) INC","IE00BJJMRZ35.SGD":"JANUS HENDERSON GLOBAL LIFE SCIENCES \"I2\" (SGDHDG) ACC","SG9999015945.SGD":"LionGlobal Disruptive Innovation Fund A SGD","LU0965509101.SGD":"AB LOW VOLATILITY EQUITY PORTFOLIO \"A\" (SGDHDG) ACC","LU1496350171.SGD":"FRANKLIN DIVERSIFIED BALANCED \"A\" (SGDHDG) ACC","TEVA":"梯瓦制药","LU1496350502.SGD":"FRANKLIN DIVERSIFIED DYNAMIC \"A\" (SGDHDG) ACC","LU0029864427.USD":"TEMPLETON GLOBAL \"A\" (USD) INC","LU0265550359.USD":"BGF SYSTEMATIC GLOBAL ENHANCED EQUITY YIELD \"A2\" (USD) ACC","IE00BLSP4452.SGD":"Legg Mason ClearBridge - Tactical Dividend Income A Mdis SGD-H Plus","LU0943347566.SGD":"安联收益及增长平衡基金AM H2-SGD","LU0553294199.USD":"BGF GLOBAL EQUITY INCOME \"A5G\" (USD) INC","IBD":"Inspire Corporate Bond ETF","LU2112291526.USD":"BGF WORLD HEALTHSCIENCE \"A4\" (USD) INC","IE0004445239.USD":"JANUS HENDERSON US FORTY \"A2\" (USD) ACC","IE00B19Z3581.USD":"Legg Mason ClearBridge - Value A Acc USD","LU0256863902.USD":"ALLIANZ US EQUITY \"AT\" (USD) ACC","LU2237443382.USD":"Aberdeen Standard SICAV I - Global Dynamic Dividend A MIncA USD","IE00BVYPNW00.USD":"GUINNESS GLOBAL EQUITY INCOME \"C\" (USD) ACC","LU1732800096.USD":"摩根大通环球收益基金A (irc)","LU1093756325.SGD":"FTIF - Franklin K2 Alt Strat Fd A (acc) SGD-H1","LU0266013472.USD":"AXA WF - Framlington Longevity Economy A Cap USD","IE00BN8TJ469.HKD":"FTGF CLEARBRIDGE TACTICAL DIVIDEND INCOME \"A\" (HKD) INC","LU0208291251.USD":"FRANKLIN MUTUAL U.S. VALUE \"A\" (USD) INC","ABBV":"艾伯维公司","IE00B2B36J28.USD":"JANUS HENDERSON GLOBAL LIFE SCIENCES \"I1\" (USD) INC","BK4584":"避孕概念","LU2089284900.SGD":"Allianz Global Sustainability Cl AM Dis H2-SGD","BK4585":"ETF&股票定投概念","IE00BSNM7G36.USD":"NEUBERGER BERMAN SYSTEMATIC GLOBAL SUSTAINABLE VALUE \"A\" (USD) ACC","LU0820561909.HKD":"ALLIANZ INCOME AND GROWTH \"AM\" (HKD) INC","LU0321505439.SGD":"Schroder ISF Global Dividend Maximiser A Acc SGD","LU0985481810.HKD":"SCHRODER ISF GLOBAL EQUITY YIELD \"A\" (HKD) INC M","LU0965509010.AUD":"AB LOW VOLATILITY EQUITY PORTFOLIO \"AD\" (AUDHDG) INC"},"translate_title":"制药股综述：PFE 2025年展望、MRK和ABBV的并购交易","themeId":null,"isJumpTheme":false,"ttsUrl":null,"symbols_score_info":{"TEVA":1,"ABBV":1,"MRK":1,"IBD":1,"CHMP":1,"CD":1,"PFE":1,"SNY":1},"content_text":"This week, Pfizer PFE issued its financial guidance for 2025. Sanofi SNY and Teva Pharmaceutical’s TEVA inflammatory bowel disease (IBD) study on their candidate, duvakitug (TEV’574), met its primary endpoints. Merck MRK inked an exclusive global licensing deal with China’s Hansoh Pharma for the latter’s oral GLP-1-based obesity candidate.  AbbVie ABBV also announced an acquisition in the immunology space.\nHere's a recap of the week’s most important stories.\nPfizer Issues 2025 Financial Outlook\nPfizer announced encouraging guidance for 2025. In 2025, Pfizer expects to record total revenues between $61.0 billion and $64.0 billion.  On an operational basis, revenues in 2025 are expected to rise in a range of approximately flat to 5% from the midpoint of 2024 guidance, excluding the impact of approximately $1.2 billion of non-recurring revenues for Paxlovid.\nAdjusted earnings are expected in the range of $2.80-$3.00, representing expected operational growth (excluding the Fx impact) in the range of 10%-18% year over year from the midpoint of the 2024 guidance, excluding the impact of certain non-recurring items.\nPfizer also maintained its previously issued financial guidance for 2024. In 2024, Pfizer expects total revenues in the range of $61.0-$64.0 billion, while adjusted earnings are expected in the range of $2.75-$2.95 per share.\nSanofi, Teva’s IBD Candidate Meets Primary Goal in Study\nSanofi and Teva’s phase IIb study evaluating their pipeline candidate, duvakitug (TEV’574), for treating ulcerative colitis (UC) and Crohn’s disease (CD), met its primary endpoints. UC and CD are the most common forms of IBD, a space gaining immense popularity.\nIn the study called RELIEVE UCCD study, 47.8% of patients with UC treated with a high dose of duvakitug, a TL1A inhibitor, and 36.2% of patients treated with a low dose of the drug achieved clinical remission compared to 20.45% on placebo at week 14.  In patients with CD, 26.1% treated with low-dose and 47.8% treated with high-dose duvakitug achieved endoscopic response compared to 13.0% on placebo at week 14. The data exceeded the companies’ internal expectations. The companies believe that duvakitug has the potential to become a differentiated medicine for IBD patients. \nTeva and Sanofi plan to begin a phase III program on duvakitug, pending regulatory discussions. Sanofi will lead the phase III clinical development program.\nMerck Enters Obesity Space With Hansoh Pharma Deal\nMerck announced that it is in-licensing exclusive global rights to develop, manufacture and commercializea preclinical GLP-1 receptor agonist, HS-10535, from Chinese biotech Hansoh Pharma. For the exclusive deal, Merck will make an upfront payment of $112 million to Hansoh Pharma, with the latter also being entitled to receive up to $1.9 billion in milestone payments and royalties on sales. Hansoh has an option to co-promote or solely commercialize HS-10535 in China. This deal marks Merck’s entry into the lucrative obesity market.\nMerck announced that it is discontinuing two clinical development programs evaluating fixed-dose combinations of its cancer candidates, vibostolimab and favezelimab with Keytruda. Merck is discontinuing the phase III KeyVibe studies (KeyVibe-003 and KeyVibe-007) evaluating the fixed-dose combination of vibostolimab, an anti-TIGIT antibody and Keytruda in a non-small cell lung cancer indication based on the recommendation of an independent Data Monitoring Committee. Both the studies met the pre-specified futility criteria for the primary endpoint of overall survival. Merck is also ending the phase III KeyVibe-006 study and other vibostolimab studies.\nSeparately, Merck has also decided to end the development program on favezelimab. The company will stop enrolment in the phase III KEYFORM-008 evaluating the fixed-dose combination of favezelimab and Keytruda for certain patients with relapsed or refractory classical Hodgkin lymphoma.\nThe European Medicines Agency’s Committee for Medicinal Products for Human Use (CHMP) gave a positive opinion recommending approval of Merck’s novel HIF-2α inhibitor, Welireg, for two indications. The CHMP has recommended approving Welireg for certain previously treated patients with advanced renal cell carcinoma and certain patients with von Hippel-Lindau disease-associated tumors. Welireg is already approved for both indications in the United States.\nThe FDA accepted Merck’s biologics license application seeking approval of clesrovimab (MK-1654), its prophylactic monoclonal antibody to protect infants from respiratory syncytial virus (RSV) disease during their first RSV season. The FDA decision is expected on June 10, 2025.\nMerck’s two pivotal phase III studies evaluating a once-daily, oral, two-drug, single-tablet regimen of doravirine and islatravir met efficacy success criteria for non-inferiority to comparator antiretroviral therapies in adults with virologically suppressed HIV-1.\nAbbVie to Buy Nimble to Strengthen Immunology Pipeline\nAbbVie announced a definitive agreement to acquire private biotech Nimble Therapeutics, which will add the latter’s lead pipeline candidate, an oral peptide IL23R inhibitor, in preclinical development for psoriasis. The acquisition will strengthen AbbVie’s immunology pipeline.\nNimble is also making other oral peptide-based therapeutics for autoimmune diseases, leveraging its proprietary peptide synthesis platform. To acquire Nimble, AbbVie will make a cash payment of $200 million, with the former also being entitled to some potential milestone payments.\nThe NYSE ARCA Pharmaceutical Index declined 2.23% in the past five trading sessions.\n\nLarge Cap Pharmaceuticals Industry 5YR % Return\n\nLarge Cap Pharmaceuticals Industry 5YR % Return\n\nHere’s how the eight major stocks performed in the previous five trading sessions.\nImage Source: Zacks Investment Research\nIn the last five trading sessions, Pfizer rose the most (1.5%), while Novo Nordisk declined the most (4.8%).\nIn the past six months, while AbbVie rose the most (0.7%), Novo Nordisk declined the most (27.1%).\n(See the last pharma stock roundup here: LLY’s Zepbound Success, FDA Updates for MRK, JNJ)\nWhat's Next in the Pharma World?\nWatch this space for regular pipeline and regulatory updates next week.\nPfizer, Merck, AbbVie, Sanofi and Teva each have a Zacks Rank #3 (Hold). You can see the complete list of today’s Zacks #1 Rank (Strong Buy) stocks here.\nWant the latest recommendations from Zacks Investment Research? Today, you can download 7 Best Stocks for the Next 30 Days. Click to get this free report\nSanofi (SNY) : Free Stock Analysis Report\nPfizer Inc. (PFE) : Free Stock Analysis Report\nMerck & Co., Inc. (MRK) : Free Stock Analysis Report\nTeva Pharmaceutical Industries Ltd. (TEVA) : Free Stock Analysis Report\nAbbVie Inc. (ABBV) : Free Stock Analysis Report\nTo read this article on Zacks.com click here.\nZacks Investment Research","kind":"highlight","is_publish_news":true,"is_publish_highlight":false,"is_publish_live":false,"is_publish_wemedia":null,"editions":null,"column":"","sentiment":"0","news_tag":"","news_rank":0,"symbols":[],"gpt_button":0},"commentList":[],"isCommentEnd":true,"newsSizeData":{"likeSize":0,"commentSize":0,"repostSize":0,"favoriteSize":0,"likeStatus":false,"favoriteStatus":false},"APP":{"userAgent":"Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)","isDev":false,"isTTM":true,"deviceId":"web-server-community-laohu8-v3","version":"4.29.3","shortVersion":"4.29.3","platform":"web","vendor":"web","appName":"ttm","isIOS":false,"isAndroid":false,"isTiger":false,"isTHS":false,"isWeiXin":false,"isWeiXinMini":false,"isWeiBo":false,"isQQ":false,"isBaiduSwan":false,"isBaiduBox":false,"isDingTalk":false,"isToutiao":false,"isOnePlus":false,"isHuaWei":false,"isXiaomi":false,"isXiaomiWebView":false,"isOppo":false,"isVivo":false,"isSamsung":false,"isMobile":false},"href":"/m/news/2492441235"}