Johnson & Johnson Unveils Promising Results for Dual-Targeting CAR T-Cell Therapy in Large B-Cell Lymphoma Study

Reuters06-13

Johnson & Johnson Unveils Promising Results for Dual-Targeting CAR T-Cell Therapy in Large B-Cell Lymphoma Study

Johnson & Johnson has announced the first clinical data from an ongoing Phase 1b study for JNJ-90014496 (JNJ-4496), an investigational dual-targeting anti-CD19/CD20 bispecific autologous chimeric antigen receptor $(CAR)$ T-cell therapy. This therapy is being studied in patients with relapsed or refractory large B-cell lymphoma (R/R LBCL) who have not previously undergone CAR T-cell therapy. The findings indicate a promising safety profile and suggest a 75-80% complete response rate among evaluable patients at the recommended Phase 2 dose. These results were presented at the 2025 European Hematology Association (EHA) Congress. Further global clinical study data will be presented at the 2025 International Conference on Malignant Lymphoma, scheduled from June 17-21.

Disclaimer: This news brief was created by Public Technologies (PUBT) using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Johnson & Johnson published the original content used to generate this news brief via PR Newswire (Ref. ID: LA09477) on June 13, 2025, and is solely responsible for the information contained therein.

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