Xenetic Biosciences Announces New Clinical Study Agreement with PeriNess to Advance DNase Platform for Large B Cell Lymphoma Treatment

Reuters07-30
Xenetic Biosciences Announces New Clinical Study Agreement with PeriNess to Advance DNase Platform for Large B Cell Lymphoma Treatment

Xenetic Biosciences, Inc. has announced a new clinical study agreement with its collaboration partner, PeriNess Ltd., to explore the potential of DNase I in combination with anti-CD19 CAR T cells for treating large B cell lymphoma. This investigator-initiated study, to be conducted at the Tel-Aviv Sourasky Medical Center, will primarily assess the safety and tolerability of this combination therapy. Secondary objectives include evaluating the efficacy through complete response rate, duration of response, and overall survival. The study aims to improve clinical outcomes by addressing the negative effects of Neutrophil Extracellular Traps (NETs) on CAR T-cell performance. Results of the study have not yet been presented and are expected in the future.

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