Actinium Pharmaceuticals Unveils Preclinical Data Showing ATNM-400 Overcomes Osimertinib Resistance in EGFR-Mutated NSCLC at AACR-NCI-EORTC Conference

Reuters10-14
Actinium Pharmaceuticals Unveils Preclinical Data Showing ATNM-400 Overcomes Osimertinib Resistance in EGFR-Mutated NSCLC at AACR-NCI-EORTC Conference

Actinium Pharmaceuticals Inc. announced that the first preclinical data from its ATNM-400 program in non-small cell lung cancer (NSCLC) has been accepted for presentation at the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics, scheduled for October 22-26, 2025. ATNM-400 is a first-in-class Actinium-225 antibody radioconjugate with demonstrated preclinical activity in both prostate cancer and NSCLC. The new findings indicate that ATNM-400 can overcome resistance to the EGFR inhibitor osimertinib in EGFR-mutated NSCLC, addressing a significant unmet clinical need. The results will be presented during Poster Session C on October 25, 2025.

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