Quince Therapeutics Inc. recently addressed investor communications regarding the efficacy of N-acetyl-L-leucine (NALL) in treating ataxia-telangiectasia. During a Virtual Investor Day, a company presentation stated that a Phase 2 study of NALL in this condition had failed across all endpoints. This statement was later removed from public materials, with the company advising investors not to rely on it. Quince clarified that the statement was based on a peer-reviewed article in the European Journal of Paediatric Neurology, which reported no significant improvements in ataxia symptoms or motor function, despite some symptom relief, but was not related to the specific Phase 2 study referenced in the presentation.
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