Whitehawk Therapeutics Advances HWK-007 ADC Targeting PTK7 in Solid Tumors

Reuters10-25

Whitehawk <a href="https://laohu8.com/S/LENZ">Therapeutics</a> Advances HWK-007 ADC Targeting PTK7 in Solid Tumors

Whitehawk Therapeutics Inc. announced new data from a real-world analysis evaluating Protein Tyrosine Kinase 7 (PTK7) as a broadly expressed and clinically relevant target across solid tumors. The findings, presented at the 2025 AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics, indicate that PTK7 is the third most highly expressed tumor marker among clinically validated and emerging antibody drug conjugate $(ADC)$ targets, present in approximately 70% of tumors. PTK7 expression was found to be stable across different histologic subtypes, disease stages, and metastatic statuses in cancers such as lung, ovarian, and endometrial. Whitehawk Therapeutics is developing HWK-007, a PTK7-targeting ADC utilizing a cleavable linker for delivery of a Topoisomerase I inhibitor payload, with plans to submit an Investigational New Drug application to the U.S. Food and Drug Administration by year-end and initiate clinical evaluation in non-small cell lung cancer, ovarian, and endometrial cancers.

Disclaimer: This news brief was created by Public Technologies (PUBT) using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Whitehawk Therapeutics Inc. published the original content used to generate this news brief via PR Newswire (Ref. ID: LA05976) on October 24, 2025, and is solely responsible for the information contained therein.

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