-- First Half Revenue Declined 3.9% at Constant Exchange Rate (CER), -6.9%
at Actual Exchange Rates $(AER)$, Impacted by Generic Erosion of VYVANSE$(R)$
and FX Headwind
-- Core Operating Profit Declined 8.8% at CER in the First Half,
Reflecting Revenue Performance and Product Mix; Impact Partially Offset
by Operational Efficiencies
-- First Half Reported Operating Profit (-27.7% at AER) Impacted by
Impairment Losses Incurred in Q2
OSAKA, Japan--(BUSINESS WIRE)--October 30, 2025--
Takeda (TOKYO:4502/NYSE:TAK) today announced earnings results for the first half of fiscal year 2025 (six months ended Sep 30, 2025) and updated its full-year outlook.
Takeda chief executive officer, Christophe Weber, commented:
"Takeda's fiscal year 2025 first half results are consistent with our expectations for core business progress in this year of transition to a new phase focusing on new product launches. Our updated full-year outlook reflects impairment charges associated with strategic pipeline decisions taken in Q2, as well as transactional FX.
"Looking ahead, our current Growth and Launch Products portfolio will continue to generate moderate growth, which will accelerate in the future with new launches. We see FY2025 as a pivotal year for Takeda with regulatory filings for rusfertide and oveporexton expected in the second half of the year, as well as Phase 3 results for zasocitinib. We continue to expand our external partnerships to enhance the depth and breadth of our R&D pipeline and recently announced a global strategic partnership with Innovent Biologics to further strengthen our position in oncology.
"With this momentum in our pipeline, we're confident in Takeda's ability to deliver life-transforming treatments and long-term value for patients and shareholders, and we're excited for the future."
Takeda chief financial officer, Milano Furuta, commented:
"Our financial results for the first half of FY2025 were driven by year-over-year impact from generic erosion of VYVANSE, as anticipated. In the second half, we expect this generic erosion impact to moderate and Growth and Launch Product growth to increase. Our updated outlook for the full year reflects the effects of transactional FX fluctuations and impairment losses on intangible assets associated with the gamma delta T-cell therapy platform--with strong OPEX management offsetting changes in product mix.
"We are confident in our business fundamentals as we look to the second half of this transitional year for Takeda."
FINANCIAL HIGHLIGHTS for FY2025 H1 Ended September 30, 2025
(Billion yen, except percentages and per share amounts)
-----------------------------------------------------------------------------
vs. PRIOR YEAR
FY2025 H1 FY2024 H1 (Actual % change)
----------------------------------- --------- --------- ------------------
Revenue 2,219.5 2,384.0 -6.9%
----------------------------------- --------- --------- ------------------
Operating Profit 253.6 350.6 -27.7%
----------------------------------- --------- --------- ------------------
Net Profit 112.4 187.3 -40.0%
----------------------------------- --------- --------- ------------------
EPS (Yen) 72 119 -39.8%
----------------------------------- --------- --------- ------------------
Operating Cash Flow 593.7 451.3 +31.6%
----------------------------------- --------- --------- ------------------
Adjusted Free Cash Flow (Non-IFRS) 525.4 247.5 +112.3%
----------------------------------- --------- --------- ------------------
Core (Non-IFRS)
(Billion yen, except percentages and per share amounts)
----------------------------------------------------------------------------
vs. PRIOR YEAR vs. PRIOR YEAR
FY2025 H1 FY2024 H1 (Actual % change) (CER % change)
----------------- --------- --------- ------------------ ---------------
Revenue 2,219.5 2,384.0 -6.9% -3.9%
----------------- --------- --------- ------------------ ---------------
Operating Profit 639.2 719.9 -11.2 % -8.8%
----------------- --------- --------- ------------------ ---------------
Margin 28.8% 30.2% -1.4 pp _
----------------- --------- --------- ------------------ ---------------
Net Profit 438.6 489.1 -10.3% -11.1%
----------------- --------- --------- ------------------ ---------------
EPS (Yen) 279 310 -10.0% -10.8%
----------------- --------- --------- ------------------ ---------------
FY2025 Outlook
Updating Full Year Management Guidance, and Reported and Core Forecasts
Takeda has updated its full year outlook to reflect foreign exchange impacts
and impairment charges related to the cell therapy platform.
FY2025 Management Guidance Core Change at CER (Non-IFRS)
------------------------------------------------------------------------------
FY2025 ORIGINAL MANAGEMENT FY2025 REVISED MANAGEMENT
GUIDANCE (May 2025) GUIDANCE (October 2025)
--------------------- -------------------------- ---------------------------
Core Revenue Broadly flat Broadly flat
--------------------- -------------------------- ---------------------------
Core Operating Profit Broadly flat Low-single-digit % decline
--------------------- -------------------------- ---------------------------
Core EPS (Yen) Broadly flat Low-single-digit % decline
--------------------- -------------------------- ---------------------------
FY2025 Reported and Core Forecasts
(Billion yen, except percentages and per share amounts)
---------------------------------------------------------------------------
FY2025 FY2025
ORIGINAL FORECAST REVISED FORECAST
(May 2025) (October 2025)
----------------------------------- ------------------ ------------------
Revenue 4,530.0 4,500.0
----------------------------------- ------------------ ------------------
Core Revenue (Non-IFRS) 4,530.0 4,500.0
----------------------------------- ------------------ ------------------
Operating Profit 475.0 400.0
----------------------------------- ------------------ ------------------
Core Operating Profit (Non-IFRS) 1,140.0 1,130.0
----------------------------------- ------------------ ------------------
Net Profit 228.0 153.0
----------------------------------- ------------------ ------------------
EPS (Yen) 145 97
----------------------------------- ------------------ ------------------
Core EPS (Yen) (Non-IFRS) 485 479
----------------------------------- ------------------ ------------------
Adjusted Free Cash Flow (Non-IFRS) 750.0-850.0 600.0-700.0
----------------------------------- ------------------ ------------------
Annual Dividend per Share (Yen) 200 200
----------------------------------- ------------------ ------------------
Additional Information About Takeda's FY2025 H1 Results
For more details about Takeda's FY2025 H1 results, commercial progress, pipeline updates and other financial information, including key assumptions in the FY2025 forecast and management guidance as well as definitions of non-IFRS measures, please refer to Takeda's FY2025 H1 investor presentation (available at https://www.takeda.com/investors/financial-results/quarterly-results/).
About Takeda
Takeda is focused on creating better health for people and a brighter future for the world. We aim to discover and deliver life-transforming treatments in our core therapeutic and business areas, including gastrointestinal and inflammation, rare diseases, plasma-derived therapies, oncology, neuroscience and vaccines. Together with our partners, we aim to improve the patient experience and advance a new frontier of treatment options through our dynamic and diverse pipeline. As a leading values-based, R&D-driven biopharmaceutical company headquartered in Japan, we are guided by our commitment to patients, our people and the planet. Our employees in approximately 80 countries and regions are driven by our purpose and are grounded in the values that have defined us for more than two centuries. For more information, visit www.takeda.com.
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