Allogene Therapeutics Unveils Pivotal Phase 2 ALPHA3 Trial of Cema-cel in Large B-Cell Lymphoma

Reuters11-03

Allogene <a href="https://laohu8.com/S/LENZ">Therapeutics</a> Unveils Pivotal Phase 2 ALPHA3 Trial of Cema-cel in Large B-Cell Lymphoma

Allogene Therapeutics Inc. has announced that a Trial-in-Progress poster for the pivotal Phase 2 ALPHA3 trial will be presented at the 2025 American Society of Hematology $(ASH)$ Annual Meeting in Orlando, Florida. The ALPHA3 study is evaluating cemacabtagene ansegedleucel (cema-cel), an investigational anti-CD19 AlloCAR T product, as a first-line consolidation therapy in patients with large B-cell lymphoma (LBCL) who remain minimal residual disease (MRD) positive after standard chemoimmunotherapy. The randomized, open-label trial compares cema-cel administered following standard FC lymphodepletion versus observation. Results from the study have not yet been presented; a futility analysis is expected in the first half of 2026.

Disclaimer: This news brief was created by Public Technologies (PUBT) using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Allogene Therapeutics Inc. published the original content used to generate this news brief via GlobeNewswire (Ref. ID: GNW9567277-en) on November 03, 2025, and is solely responsible for the information contained therein.

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