Arvinas Reports Positive Phase 1 Data and Advances Pipeline in Q3 2025 Update

Reuters11-05

Arvinas Reports Positive Phase 1 Data and Advances Pipeline in Q3 2025 Update

Arvinas Inc. announced its third quarter 2025 financial results and provided a corporate update. The company reported positive data from Phase 1 clinical trials of ARV-102 in both healthy volunteers and patients with Parkinson's disease. Preclinical data from ARV-806 showed robust and differentiated activity in models of KRAS G12D-mutated cancer. Additionally, preclinical data from ARV-027 demonstrated significant degradation of polyQ-AR in muscle, supporting further evaluation as a potential disease-modifying therapy in spinal bulbar muscular atrophy (SBMA). Arvinas also announced an agreement with Pfizer to jointly select a third party for the commercialization and potential further development of vepdegestrant. The company highlighted these developments as part of its ongoing efforts to advance its PROTAC degrader portfolio.

Disclaimer: This news brief was created by Public Technologies (PUBT) using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Arvinas Inc. published the original content used to generate this news brief via EDGAR, the Electronic Data Gathering, Analysis, and Retrieval system operated by the U.S. Securities and Exchange Commission (Ref. ID: 0001628280-25-049235), on November 05, 2025, and is solely responsible for the information contained therein.

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The company reported positive data from Phase 1 clinical trials of ARV-102 in both healthy volunteers and patients with Parkinson's disease. Preclinical data from ARV-806 showed robust and differentiated activity in models of KRAS G12D-mutated cancer. Additionally, preclinical data from ARV-027 demonstrated significant degradation of polyQ-AR in muscle, supporting further evaluation as a potential disease-modifying therapy in spinal bulbar muscular atrophy (SBMA). Arvinas also announced an agreement with Pfizer to jointly select a third party for the commercialization and potential further development of vepdegestrant. The company highlighted these developments as part of its ongoing efforts to advance its PROTAC degrader portfolio.\n      </p>\n</div><div xmlns:xsd=\"http://www.w3.org/2001/XMLSchema\" xmlns:xsi=\"http://www.w3.org/2001/XMLSchema-instance\">\n<em>Disclaimer: <span>This news brief was created by Public Technologies (PUBT) using generative artificial intelligence. 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The company reported positive data from Phase 1 clinical trials of ARV-102 in both healthy volunteers and patients with Parkinson's disease. Preclinical data from ARV-806 showed robust and differentiated activity in models of KRAS G12D-mutated cancer. Additionally, preclinical data from ARV-027 demonstrated significant degradation of polyQ-AR in muscle, supporting further evaluation as a potential disease-modifying therapy in spinal bulbar muscular atrophy (SBMA). Arvinas also announced an agreement with Pfizer to jointly select a third party for the commercialization and potential further development of vepdegestrant. The company highlighted these developments as part of its ongoing efforts to advance its PROTAC degrader portfolio.\n      \n\nDisclaimer: This news brief was created by Public Technologies (PUBT) using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Arvinas Inc. published the original content used to generate this news brief via EDGAR, the Electronic Data Gathering, Analysis, and Retrieval system operated by the U.S. Securities and Exchange Commission (Ref. 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