Press Release: NewAmsterdam Pharma Provides Corporate Update and Reports Third Quarter Financial Results

Dow Jones11-05

-- Marketing Authorization Applications for obicetrapib and FDC of obicetrapib plus ezetimibe accepted for review by European Medicines Agency --

-- BROOKLYN and BROADWAY pooled MACE analysis published in the Journal of the American College of Cardiology, while the BROADWAY pre-specified Alzheimer's substudy was published in the Journal of Prevention of Alzheimer's Disease --

-- $756.0 million in cash, cash equivalents and marketable securities at September 30, 2025 --

NAARDEN, the Netherlands and MIAMI, Nov. 05, 2025 (GLOBE NEWSWIRE) -- NewAmsterdam Pharma Company N.V. (Nasdaq: NAMS or "NewAmsterdam" or the "Company"), a late-stage, clinical biopharmaceutical company developing oral, non-statin medicines for patients at risk of cardiovascular disease ("CVD") with elevated low-density lipoprotein cholesterol ("LDL-C"), for whom existing therapies are not sufficiently effective or well-tolerated, today announced financial results for the quarter ended September 30, 2025 and provided a corporate update.

"We remain acutely focused on our mission to deliver obicetrapib, as a novel, well-tolerated, and conveniently administered therapy for millions of patients with cardiometabolic disease who continue to struggle to reach their LDL-C goals," said Michael Davidson, M.D., Chief Executive Officer of NewAmsterdam. "In the third quarter, we achieved a significant regulatory milestone with the European Medicines Agency's ("EMA") acceptance for review of the marketing authorization applications ("MAAs"), by our partner Menarini, for both obicetrapib monotherapy and the fixed-dose combination ("FDC") with ezetimibe. These submissions, supported by data from our pivotal BROADWAY, BROOKLYN and TANDEM trials, represent an important step toward bringing obicetrapib to patients across Europe."

"In parallel, we continue to advance our broader clinical development strategy, including PREVAIL, our ongoing cardiovascular outcomes trial ("CVOT"), and REMBRANDT, our Phase 3 imaging trial," continued Dr. Davidson. "We are also making meaningful progress building our global infrastructure to support the potential launch of obicetrapib, if approved. As we engage with the investment and medical communities through upcoming conference and medical meetings, we look forward to sharing new pooled efficacy and safety data and to further highlighting our strategic vision for obicetrapib as a differentiated therapy in a large and growing market."

Clinical Development Updates

NewAmsterdam is developing obicetrapib, an oral, low-dose and once-daily investigational cholesteryl ester transfer protein ("CETP") inhibitor, as the preferred LDL-C lowering therapy to be used in patients at risk of CVD for whom existing therapies are not sufficiently effective or well-tolerated.

   -- In July 2025, NewAmsterdam announced additional results from the 
      prespecified Alzheimer's disease ("AD") biomarker analysis in the Phase 3 
      BROADWAY trial, presented at the 2025 Alzheimer's Association 
      International Conference ("AAIC"), which NewAmsterdam believes further 
      support the potential of obicetrapib to modify key biomarkers of AD 
      pathology over a 12-month period in patients with atherosclerotic 
      cardiovascular disease ("ASCVD"). 
 
          -- In ApoE4/E4 carriers, the highest risk category for Alzheimer's 
             disease, obicetrapib was observed to reduce p-tau217 levels by 
             20.5%, over 12 months, compared to placebo (p=0.010, n=29). 
 
          -- In October 2025, the data was published in the Journal of 
             Prevention of Alzheimer's Disease. 
 
   -- In August 2025, NewAmsterdam presented pooled efficacy and safety data 
      from its pivotal Phase 3 BROADWAY and BROOKLYN trials at the European 
      Society of Cardiology Congress ("ESC") 2025, along with the simultaneous 
      publication in the Journal of the American College of Cardiology, 
      highlighting obicetrapib's performance across diverse lipid-lowering 
      backgrounds observed in these trials. The presentation and publication 
      underscore the Company's continued momentum in advancing obicetrapib as a 
      differentiated oral therapy for patients with elevated LDL-C. 
 
   -- In November 2025, NewAmsterdam expects to present additional data at the 
      American Heart Association's Scientific Sessions 2025, highlighting 
      obicetrapib's impact on LDL particles observed in BROADWAY and BROOKLYN. 

Upcoming Milestones and Ongoing Trials:

Following the successful completion and positive topline results of the Phase 3 BROADWAY, TANDEM, and BROOKLYN trials, NewAmsterdam plans to announce additional data from these trials relating to obicetrapib and the FDC of obicetrapib plus ezetimibe.

The following Phase 3 trials are currently ongoing:

   -- PREVAIL Phase 3 trial: PREVAIL is a CVOT evaluating obicetrapib in 
      patients with a history of ASCVD, whose LDL-C is not adequately 
      controlled despite being on maximally tolerated lipid-lowering therapy. 
      NewAmsterdam completed enrollment of over 9,500 patients in April 2024. 
 
   -- REMBRANDT Phase 3 trial: The trial will utilize coronary computed 
      tomography angiography imaging to evaluate the effect of obicetrapib plus 
      ezetimibe FDC on coronary plaque. The placebo-controlled, double-blind, 
      randomized, Phase 3 trial is being conducted in adult participants with 
      high-risk ASCVD with evidence of coronary plaque who are not adequately 
      controlled by their maximally tolerated lipid-modifying therapy, to 
      assess the impact of the obicetrapib 10 mg plus ezetimibe 10 mg FDC daily 
      on coronary plaque and inflammation characteristics. The trial is 
      expected to enroll 300 patients. 

NewAmsterdam also plans to initiate the RUBENS Phase 3 clinical trial to evaluate obicetrapib in combination with ezetimibe in patients with type 2 diabetes or metabolic syndrome that require additional lowering of LDL-C despite treatment with available therapy. The RUBENS trial is expected to initiate in the fourth quarter of 2025.

Corporate Updates

   -- In August 2025, the EMA accepted for review the MAAs for obicetrapib 10 
      mg monotherapy and the FDC of 10 mg obicetrapib plus 10 mg ezetimibe for 
      the treatment of primary hypercholesterolemia, including heterozygous 
      familial and non-familial or mixed dyslipidemia. The EMA's validation of 
      the submissions, made by NewAmsterdam's partner, A. Menarini 
      International Licensing S.A. ("Menarini"), represents a key regulatory 
      milestone. The submissions are supported by data from the BROADWAY, 
      BROOKLYN, and TANDEM pivotal Phase 3 trials. 

Third Quarter Financial Results

   -- Cash Position: As of September 30, 2025, NewAmsterdam recorded cash, cash 
      equivalents and marketable securities of $756.0 million, compared to 
      $834.2 million as of December 31, 2024. The decrease was primarily driven 
      by ongoing operating expenditures. 
 
   -- Revenue: NewAmsterdam recognized $0.3 million in revenue for the quarter 
      ended September 30, 2025, compared to $29.1 million in the same period in 
      2024. The decrease was primarily attributable to the recognition of $27.3 
      million of revenue from a license agreement with Menarini related to a 
      clinical development milestone which was earned in the quarter ended 
      September 30, 2024 while there were no clinical milestones earned in the 
      quarter ended September 30, 2025. 
 
   -- Research and Development ("R&D") Expenses: R&D expenses were $31.0 
      million in the quarter ended September 30, 2025, compared to $35.7 
      million for the same period in 2024. This decrease was primarily due to a 
      decrease in clinical expenses and manufacturing expenses, partially 
      offset by an increase in personnel expenses, including share-based 
      compensation and non-clinical expenses related to pipeline expansion and 
      product lifecycle management. Share-based compensation expenses included 
      with R&D expenses totaled $5.0 million in the quarter ended September 30, 
      2025, compared to $3.0 million for the same period in 2024. 
 
   -- Selling, General and Administrative ("SG&A") Expenses: SG&A expenses were 
      $24.5 million in the quarter ended September 30, 2025, compared to $18.4 
      million for the same period in 2024. This increase was primarily due to 
      an increase in personnel expenses, including share-based compensation. 
      Share-based compensation expenses included with SG&A expenses totaled 
      $10.0 million in the quarter ended September 30, 2025, compared to $5.0 
      million for the same period in 2024. 
 
   -- Net loss: Net loss for the quarter ended September 30, 2025, was $72.0 
      million, compared to net loss of $16.6 million for the same period in 
      2024. The individual components of the change are described above in 
      addition to non-cash losses related to changes in the fair value of our 
      derivative liabilities. 

About Obicetrapib

Obicetrapib is a novel, oral, low-dose CETP inhibitor that NewAmsterdam is developing to overcome the limitations of current LDL-lowering treatments. In each of the Company's Phase 2 trials, ROSE2, TULIP, ROSE, and OCEAN, as well as the Company's Phase 3 BROOKLYN, BROADWAY and TANDEM trials, evaluating obicetrapib as monotherapy or combination therapy, the Company observed statistically significant LDL-lowering combined with a side effect profile similar to that of placebo. The Company commenced the Phase 3 PREVAIL cardiovascular outcomes trial in March 2022, which is designed to assess the potential of obicetrapib to reduce occurrences of MACE. The Company completed enrollment of PREVAIL in April 2024 and randomized over 9,500 patients. Commercialization rights of obicetrapib in Europe, either as a monotherapy or as part of a fixed-dose combination with ezetimibe, have been exclusively granted to the Menarini Group, an Italy-based, leading international pharmaceutical and diagnostics company.

About Cardiovascular Disease

Cardiovascular disease remains the leading cause of death globally, despite the availability of lipid-lowering therapies ("LLTs"). By 2050 more than 184 million U.S. adults are expected to be affected by CVD and hypertension, including 27 million with coronary heart disease and 19 million with stroke. In the United States from 2019 through 2022, CVD age-adjusted mortality rates increased by 9%, reversing the trend observed since 2010 and undoing nearly a decade of progress. Despite the availability of high-intensity statins and non-statin LLTs, LDL-C target level attainment remains low, contributing to residual cardiovascular risk, and underscoring a significant clinical need for improved therapeutic regimens. Even with 269 million LLT prescriptions written over the last 12 months, 30 million under-treated US adults are not at their risk-based LDL-C goal, of which 13 million have ASCVD. Less than 1 in 4 patients with ASCVD achieve an LDL-C goal of less than 70 mg/dL and only 10% of very high risk ASCVD patients achieve the goal below 55 mg/dL. In addition to the 30 million under-treated U.S. adults, there are 10 million patients diagnosed with elevated LDL-C who are not taking any LLTs including statins. Beyond LDL-C, additional factors are at play, such as lifestyle choices, tobacco use, and obesity, as well as inflammation, thrombosis, triglyceride levels, elevated Lp(a) levels, and type 2 diabetes.

Alzheimer's Analysis

In BROADWAY, a pre-specified analysis was designed to assess plasma biomarkers of Alzheimer's disease ("AD") in patients enrolled in the BROADWAY trial and evaluated the effects of longer duration of therapy (12 months) with a prespecified ApoE population, based on phenotypic analysis. The analysis included 1,535 patients, including 367 ApoE4 carriers (ApoE3/E4 or ApoE4/E4), whose ApoE status was able to be determined. Because this analysis was based on a subset of patients from BROADWAY (which was designed to evaluate LDL-C reductions in an ASCVD and/or HeFH population), the AD analysis was not controlled for baseline differences between the treatment and placebo populations, but statistical analyses were adjusted for baseline biomarker values and age. The absolute and percent change over 12 months in p-tau217, a key biomarker of AD pathology, was measured among patients with baseline and end of study datapoints above the lower limit of quantitation. Additional outcome measures included NFL, GFAP, p-tau181, and A<BETA>42/40 ratio absolute and percent change over 12 months. NewAmsterdam observed statistically significant lower absolute changes in p-tau217 compared to placebo over 12 months in both the full analysis set (p=0.025; n= 1,535) and in ApoE4 carriers (p=0.022; n=367) as well as favorable trends in the other AD biomarkers. Although a safety analysis was not performed in the AD analysis population, in BROADWAY obicetrapib was observed to be well-tolerated, with safety results comparable to placebo.

About NewAmsterdam

NewAmsterdam Pharma (Nasdaq: NAMS) is a late-stage clinical biopharmaceutical company whose mission is to improve patient care in populations with metabolic diseases where currently approved therapies have not been adequate or well tolerated. We seek to fill a significant unmet need for a safe, well-tolerated and convenient LDL-lowering therapy. In multiple phase 3 trials, NewAmsterdam is investigating obicetrapib, an oral, low-dose and once-daily CETP inhibitor, alone or as a fixed-dose combination with ezetimibe, as LDL-C lowering therapies to be used as an adjunct to statin therapy for patients at risk of CVD with elevated LDL-C, for whom existing therapies are not sufficiently effective or well tolerated.

Forward-Looking Statements

Certain statements included in this press release that are not historical facts are forward-looking statements for purposes of the safe harbor provisions under the United States Private Securities Litigation Reform Act of 1995. Forward-looking statements generally are accompanied by words such as "believe," "may," "will," "estimate," "continue," "anticipate," "intend," "expect," "should," "would," "plan," "predict," "potential," "seem," "seek," "future," "outlook" and similar expressions that predict or indicate future events or trends or that are not statements of historical matters. These forward-looking statements include, but are not limited to, statements regarding the Company's business and strategic plans; the Company's commercial opportunity; the therapeutic and curative potential of the Company's product candidates; the Company's clinical trials and the timing for commencing trials, enrolling patients and completing trials; the timing and forums for announcing data; the achievement and timing of regulatory filings and approvals; and plans for commercialization. These statements are based on various assumptions, whether or not identified in this press release, and on the current expectations of the Company's management and are not predictions of actual performance. These forward-looking statements are provided for illustrative purposes only and are not intended to serve as and must not be relied on as a guarantee, an assurance, a prediction, or a definitive statement of fact or probability. Actual events and circumstances are difficult or impossible to predict and may differ from assumptions. Many actual events and circumstances are beyond the control of the Company.

These forward-looking statements are subject to a number of risks and uncertainties, including changes in domestic and foreign business, market, financial, political, and legal conditions; risks related to the approval of the Company's product candidates and the timing of expected regulatory and business milestones, including potential commercialization; whether topline, initial or preliminary results from a particular clinical trial will be predictive of the final results of that trial and whether results of early clinical trials will be indicative of the results of later clinical trials, or whether projections regarding clinical outcomes will reflect actual results in future clinical trials or clinical use of our product candidates, if approved; the potential for varying interpretation of the results of clinical trials and analyses; the impact of competitive product candidates; and those risks, uncertainties and other factors discussed under the caption "Item 1A. Risk Factors" and elsewhere in the Company's most recent Form 10-K, Form 10-Q and other public filings with the Securities and Exchange Commission, which are available at www.sec.gov. Additional risks related to the Company's business include, but are not limited to: uncertainty regarding outcomes of the Company's ongoing clinical trials, particularly as they relate to regulatory review and potential approval for its product candidates; risks associated with the Company's efforts to commercialize its product candidates; the Company's ability to negotiate and enter into definitive agreements on favorable terms, if at all; the impact of competing product candidates on the Company's business; risks and uncertainties relating to intellectual property and regulatory exclusivities; the Company's ability to attract and retain qualified personnel; and the Company's ability to continue to source the raw materials for its product candidates. If any of these risks materialize or the Company's assumptions prove incorrect, actual results could differ materially from the results implied by these forward-looking statements. There may be additional risks that the Company does not presently know or that the Company currently believes are immaterial that could also cause actual results to differ from those contained in the forward-looking statements.

In addition, forward-looking statements reflect the Company's expectations, plans, or forecasts of future events and views as of the date of this press release and are qualified in their entirety by reference to the cautionary statements herein. The Company anticipates that subsequent events and developments may cause the Company's assessments to change. These forward-looking statements should not be relied upon as representing the Company's assessment as of any date subsequent to the date of this press release. Accordingly, undue reliance should not be placed upon the forward-looking statements. Neither the Company nor any of its affiliates undertakes any obligation to update these forward-looking statements, except as may be required by law.

Company Contact

Matthew Philippe

P: 1-917-882-7512

matthew.philippe@newamsterdampharma.com

Media Contact

Real Chemistry on behalf of NewAmsterdam

Christian Edgington

P: 1-513-310-6410

cedgington@realchemistry.com

Investor Contact

Precision AQ on behalf of NewAmsterdam

Austin Murtagh

P: 1-212-698-8696

austin.murtagh@precisionaq.com

 
                   NewAmsterdam Pharma Company N.V. 
                 Condensed Consolidated Balance Sheet 
                              (Unaudited) 
                                      September 30,    December 31, 
                                           2025            2024 
                                      --------------   ------------ 
(In thousands of USD) 
Assets 
Current assets: 
  Cash and cash equivalents                  538,407        771,743 
  Prepayments and other receivables           28,074         24,272 
  Employee receivables                            --          4,951 
  Marketable securities, current             164,539         62,447 
  Restricted cash                              1,308             -- 
                                       -------------   ------------ 
    Total current assets                     732,328        863,413 
Marketable securities, net of 
current portion                               53,091             -- 
Property, plant and equipment, net               323            242 
Operating right of use asset                     246            431 
Intangible assets                                439            534 
                                       -------------   ------------ 
    Total assets                             786,427        864,620 
                                       =============   ============ 
Liabilities and Shareholders' Equity 
Current liabilities: 
  Accounts payable                             3,632          4,744 
  Accrued expenses and other current 
   liabilities                                10,098         13,608 
  Deferred revenue, current                       --          6,008 
  Lease liability, current                       181            246 
  Derivative earnout liability, 
   current                                        --         44,798 
  Derivative warrant liabilities              44,361         37,514 
                                       -------------   ------------ 
    Total current liabilities                 58,272        106,918 
Lease liability, net of current 
 portion                                          85            202 
                                       -------------   ------------ 
    Total liabilities                         58,357        107,120 
                                       =============   ============ 
Commitments and contingencies (Note 
12) 
Shareholders' Equity (deficit): 
  Ordinary shares, EUR0.12 par value; 
   400,000,000 shares authorized; 
   113,172,684 and 108,064,340 shares 
   issued and outstanding as at 
   September 30, 2025 and December 
   31, 2024, respectively                     14,107         13,444 
  Additional paid-in capital               1,396,790      1,298,160 
  Accumulated loss                          (687,467)      (558,571) 
  Accumulated other comprehensive 
   income                                      4,640          4,467 
                                       -------------   ------------ 
  Total shareholders' equity                 728,070        757,500 
                                       -------------   ------------ 
Total liabilities and shareholders' 
 equity                                      786,427        864,620 
                                       =============   ============ 
 
 
                 NewAmsterdam Pharma Company N.V. 
        Condensed Consolidated Statements of Operations and 
                         Comprehensive Loss 
                            (Unaudited) 
 
                          For the three      For the nine months 
                           months ended        ended September 
                          September 30,              30, 
                          2025      2024       2025       2024 
                        --------   -------   --------   -------- 
(In thousands of USD, 
except per share 
amounts) 
Revenue                      348    29,111     22,471     32,791 
Operating expenses: 
   Research and 
    development 
    expenses              30,971    35,702    103,238    116,511 
   Selling, general and 
    administrative 
    expenses              24,520    18,412     78,936     49,340 
                         -------   -------   --------   -------- 
      Total operating 
       expenses           55,491    54,114    182,174    165,851 
                         -------   -------   --------   -------- 
Operating loss           (55,143)  (25,003)  (159,703)  (133,060) 
Other income 
(expense): 
   Interest income         6,713     4,443     21,119     12,396 
   Fair value change -- 
    earnout                   --    (5,414)     3,992    (11,020) 
   Fair value change -- 
    warrants             (23,792)    4,644     (7,440)   (19,008) 
   Loss on disposal of 
    property, plant and 
    equipment                 (1)       --         (1)        -- 
   Foreign exchange 
    gains/(losses)           218     4,682     13,137      1,270 
                         -------   -------   --------   -------- 
Loss before tax          (72,005)  (16,648)  (128,896)  (149,422) 
   Income tax expense 
    (benefit)                 --        (1)        --         (1) 
                         -------   -------   --------   -------- 
Loss for the period      (72,005)  (16,647)  (128,896)  (149,421) 
Other comprehensive 
income/(loss) 
   Unrealized 
    gain/(loss) on 
    available-for-sale 
    securities, net of 
    tax                      313        --        173         -- 
                         -------   -------   --------   -------- 
Total comprehensive 
 loss for the period, 
 net of tax              (71,692)  (16,647)  (128,723)  (149,421) 
                         -------   -------   --------   -------- 
 
 
                                 NewAmsterdam Pharma Company N.V. 
                       Condensed Consolidated Statements of Mezzanine Equity 
                                      and Shareholders' Equity 
                                            (Unaudited) 
 
                                                                    Accumulated 
(In thousands of                        Additional                     Other           Total 
USD, except                              Paid-In     Accumulated   Comprehensive   Shareholders' 
share amounts)       Shares     Amount   Capital        Loss          Income          Equity 
                  ------------  ------  ----------   -----------   -------------   ------------- 
Balance at 
 December 31, 
 2023               82,469,768  10,173     590,771      (316,973)          4,422         288,393 
                   ===========  ======  ==========   ===========   =============   ============= 
  Issuance of 
   Ordinary 
   Shares and 
   Pre-Funded 
   Warrants, net 
   of issuance 
   costs             5,871,909     759     189,207            --              --         189,966 
  Exercise of 
   warrants            926,698     121      19,674            --              --          19,795 
  Exercise of 
   stock options       452,461      60        (609)           --              --            (549) 
  Share-based 
   compensation             --      --       7,965            --              --           7,965 
  Total loss and 
   comprehensive 
   loss for the 
   period                   --      --          --       (93,767)             --         (93,767) 
                   -----------  ------  ----------   -----------   -------------   ------------- 
As at March 31, 
 2024               89,720,836  11,113     807,008      (410,740)          4,422         411,803 
                   ===========  ======  ==========   ===========   =============   ============= 
  Exercise of 
   warrants            294,521      38       6,268            --              --           6,306 
  Share-based 
   compensation             --      --       8,337            --              --           8,337 
  Total loss and 
   comprehensive 
   loss for the 
   period                   --      --          --       (39,007)             --         (39,007) 
                   -----------  ------  ----------   -----------   -------------   ------------- 
As at June 30, 
 2024               90,015,357  11,151     821,613      (449,747)          4,422         387,439 
                   ===========  ======  ==========   ===========   =============   ============= 
  Exercise of 
   Pre-Funded 
   Warrants          2,105,248     279        (279)           --              --              -- 
  Exercise of 
   stock options        45,000       5          53            --              --              58 
  Share-based 
   compensation             --      --       8,012            --              --           8,012 
  Total loss and 
   comprehensive 
   loss for the 
   period                   --      --          --       (16,647)             --         (16,647) 
                   -----------  ------  ----------   -----------   -------------   ------------- 
As at September 
 30, 2024           92,165,605  11,435     829,399      (466,394)          4,422         378,862 
                   ===========  ======  ==========   ===========   =============   ============= 
 
Balance at 
 December 31, 
 2024              108,064,340  13,444   1,298,160      (558,571)          4,467         757,500 
                   ===========  ======  ==========   ===========   =============   ============= 
  Issuance of 
   Earnout 
   Shares            1,743,136     226      40,581            --              --          40,807 
  Exercise of 
   Pre-Funded 
   Warrants          1,293,938     162        (162)           --              --              -- 
  Exercise of 
   warrants             15,942       2         410            --              --             412 
  Exercise of 
   stock options       909,140     116       2,875            --              --           2,991 
  Vesting of RSUs      142,795      18         (18)           --              --              -- 
  Share-based 
   compensation             --      --      15,213            --              --          15,213 
  Total loss and 
   comprehensive 
   loss for the 
   period                   --      --          --       (39,527)            (33)        (39,560) 
                   -----------  ------  ----------   -----------   -------------   ------------- 
As at March 31, 
 2025              112,169,291  13,968   1,357,059      (598,098)          4,434         777,363 
                   ===========  ======  ==========   ===========   =============   ============= 
  Exercise of 
   warrants                100      --           2            --              --               2 
  Exercise of 
   stock options       340,317      46       3,378            --              --           3,424 
  Vesting of 
  RSUs                     206      --          --            --              --              -- 
  Share-based 
   compensation             --      --      15,179            --              --          15,179 
  Total loss and 
   comprehensive 
   loss for the 
   period                   --      --          --       (17,364)           (107)        (17,471) 
                   -----------  ------  ----------   -----------   -------------   ------------- 
As at June 30, 
 2025              112,509,914  14,014   1,375,618      (615,462)          4,327         778,497 
                   ===========  ======  ==========   ===========   =============   ============= 
  Exercise of 
   warrants             23,826       4         633            --              --             637 
  Exercise of 
   stock options       638,944      89       5,529            --              --           5,618 
  Share-based 
   compensation             --      --      15,010            --              --          15,010 
  Total loss and 
   comprehensive 
   loss for the 
   period                   --      --          --       (72,005)            313         (71,692) 
                   -----------  ------  ----------   -----------   -------------   ------------- 
As at September 
 30, 2025          113,172,684  14,107   1,396,790      (687,467)          4,640         728,070 
                   ===========  ======  ==========   ===========   =============   ============= 
 
 
                    NewAmsterdam Pharma Company N.V. 
             Condensed Consolidated Statements of Cash Flows 
                               (Unaudited) 
 
                           For the nine months ended September 30, 
                                 2025                     2024 
                         --------------------      ------------------ 
(In thousands of USD) 
Operating activities: 
Loss for the period                  (128,896)               (149,421) 
Non-cash adjustments to 
reconcile loss before 
tax to net cash flows: 
    Depreciation and 
     amortization                         161                      62 
    Non-cash rent 
     expense                                3                       8 
    Fair value change - 
     derivative earnout 
     and warrants                       3,448                  30,028 
    Loss on disposal of 
    property, plant and 
    equipment                               1                      -- 
    Foreign exchange 
     (gains)/losses                   (13,137)                 (1,270) 
    Amortization of 
     premium/discount on 
     available-for-sale 
     debt securities                   (1,381)                     -- 
    Share-based 
     compensation                      45,402                  24,204 
Changes in working 
capital: 
    Changes in 
     prepayments and 
     other receivables                 (3,216)                 (8,769) 
    Changes in accounts 
     payable                             (409)                 (9,751) 
    Changes in accrued 
     expenses and other 
     current 
     liabilities                       (2,876)                   (708) 
    Changes in deferred 
     revenue                           (6,008)                 (5,466) 
                          -------------------      ------------------ 
Net cash used in 
 operating activities                (106,908)               (121,083) 
                          -------------------      ------------------ 
Investing activities: 
    Purchase of 
     property, plant and 
     equipment, 
     including internal 
     use software                        (146)                   (669) 
    Maturities of 
    marketable 
    securities                         71,563                      -- 
    Purchases of 
     marketable 
     securities                      (225,192)                     -- 
                          -------------------      ------------------ 
Net cash used in 
 investing activities                (153,775)                   (669) 
                          -------------------      ------------------ 
Financing activities: 
    Proceeds from 
     February 2024 
     offering of 
     Ordinary Shares and 
     Pre-Funded 
     Warrants                              --                 190,481 
    Transaction costs on 
     February 2024 issue 
     of Ordinary Shares 
     and Pre-Funded 
     Warrants                              --                    (515) 
    Transaction costs on 
     December 2024 issue 
     of Ordinary Shares 
     and Pre-Funded 
     Warrants                          (1,586)                     -- 
    Proceeds from 
     exercise of 
     warrants                             458                  13,421 
    Proceeds from 
     exercise of 
     options                           16,964                     498 
    Payment of 
     withholding taxes 
     related to net 
     share settlement of 
     exercised options                     --                    (989) 
                          -------------------      ------------------ 
Net cash provided by 
 financing activities                  15,836                 202,896 
                          -------------------      ------------------ 
Net change in cash, cash 
 equivalents and 
 restricted cash                     (244,847)                 81,144 
Foreign exchange 
 differences                           12,819                   1,135 
Cash, cash equivalents 
 and restricted cash at 
 the beginning of the 
 period                               771,743                 340,450 
                          -------------------      ------------------ 
Cash, cash equivalents 
 and restricted cash at 
 the end of the period                539,715                 422,729 
                          ===================      ================== 
Noncash financing and 
investing activities 
    Right-of-use assets 
     obtained in 
     exchange for new 
     operating lease 
     liabilities                           --                     562 
    Issuance of earnout 
    shares                             40,807                      -- 
 
Reconciliation of cash, 
cash equivalents and 
restricted cash to the 
Condensed Consolidated 
Balance Sheets 
    Cash and cash 
     equivalents                      538,407                 422,729 
    Restricted cash                     1,308                      -- 
                          -------------------      ------------------ 
                                      539,715                 422,729 
 =======================  ===================      ================== 
 

(END) Dow Jones Newswires

November 05, 2025 08:00 ET (13:00 GMT)

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