Revolution Medicines Inc. has released a corporate presentation outlining progress in its pipeline of targeted therapies for RAS-addicted cancers. The company is advancing three clinical-stage RAS$(ON)$ inhibitors: daraxonrasib (RMC-6236), elironrasib (RMC-6291), and zoldonrasib (RMC-9805). Daraxonrasib is being evaluated in monotherapy and combination studies for pancreatic ductal adenocarcinoma (PDAC) and non-small cell lung cancer (NSCLC), with phase 3 trials planned for earlier treatment lines. Early clinical data for daraxonrasib in second-line PDAC show a median progression-free survival of 8.5 months and a median overall survival of 13.1 months. The company is also advancing a G12V-selective inhibitor (RMC-5127) toward clinical readiness and expanding its global commercialization capabilities. You can access the full presentation through the link below.
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