Avenue Therapeutics' majority-owned subsidiary, Baergic Bio, is being acquired by Axsome Therapeutics, which will receive global rights to BAER-101 (also known as AZD7325), a novel oral GABAA α2,3 receptor modulator. Under the terms of the agreement, Baergic Bio shareholders are set to receive a $0.3 million upfront payment (less transaction expenses), with eligibility for milestone payments of up to $2.5 million for the first indication and $1.5 million for each additional indication. The deal also includes up to $79 million in potential sales-based milestones and a tiered mid-to-high single-digit royalty on global net sales of AXS-17. Avenue is expected to receive approximately 74% of all future payments and royalties under the agreement. Axsome plans to advance AXS-17 in epilepsy, leveraging anti-convulsant effects observed in preclinical models.
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