Akeso Begins Phase I Trial of Personalized mRNA Vaccine AK154 for Pancreatic Cancer

Reuters11-10

Akeso Begins Phase I Trial of Personalized mRNA Vaccine AK154 for Pancreatic Cancer

Akeso Inc. has announced that the first patient has been dosed in a Phase I clinical trial of its personalized mRNA vaccine candidate AK154 for the adjuvant treatment of pancreatic cancer. The study will evaluate AK154 as a monotherapy and in combination with Akeso's bispecific antibodies, cadonilimab (PD-1/CTLA-4) and ivonescimab (PD-1/VEGF), following surgical resection. AK154 is Akeso's first mRNA-based therapeutic candidate to enter clinical development. According to the company, preclinical data showed strong immunogenicity, potent anti-tumor activity, and a favorable safety profile. Clinical results from this trial have not yet been presented.

Disclaimer: This news brief was created by Public Technologies (PUBT) using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Akeso Inc. published the original content used to generate this news brief via PR Newswire (Ref. ID: CN20027) on November 10, 2025, and is solely responsible for the information contained therein.

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