Acurx Reveals Breakthrough DNA pol IIIC Inhibitor Targeting Drug-Resistant Bacteria

Reuters11-10

Acurx Reveals Breakthrough DNA pol IIIC Inhibitor Targeting Drug-Resistant Bacteria

Acurx Pharmaceuticals Inc. has announced the publication of scientific research results from its collaboration with Leiden University Medical Center, revealing for the first time the structure of ibezapolstat, a DNA polymerase IIIC (pol IIIC) inhibitor, bound to its bacterial target. The findings, published in Nature Communications, highlight the unique way ibezapolstat selectively targets Gram-positive priority pathogens, including C. difficile, MRSA, VRE, and PRSP. These results build on previously reported Phase 2 clinical efficacy of ibezapolstat in treating C. difficile infection, with a 96% initial cure rate and no recurrence. The new structural insights are already being used to advance the design of next-generation antibiotics against multi-drug-resistant bacteria.

Disclaimer: This news brief was created by Public Technologies (PUBT) using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Acurx Pharmaceuticals Inc. published the original content used to generate this news brief on November 10, 2025, and is solely responsible for the information contained therein.

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The findings, published in Nature Communications, highlight the unique way ibezapolstat selectively targets Gram-positive priority pathogens, including C. difficile, MRSA, VRE, and PRSP. These results build on previously reported Phase 2 clinical efficacy of ibezapolstat in treating C. difficile infection, with a 96% initial cure rate and no recurrence. The new structural insights are already being used to advance the design of next-generation antibiotics against multi-drug-resistant bacteria.\n      \n\nDisclaimer: This news brief was created by Public Technologies (PUBT) using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. 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