-- BBOT debuted as a publicly traded company focused on optimized target
coverage for patients with tumors driven by RAS and PI3K<ALPHA> and a
synergistic portfolio that is designed to enable targeted KRAS
combinations
-- Advanced three ongoing Phase 1 clinical trials, with clinical data
readouts from each program expected in 2026
-- Cash runway expected to fund BBOT operations into 2028
-- Appointed industry veteran Uneek Mehra as Chief Financial Officer
SOUTH SAN FRANCISCO, Calif., Nov. 12, 2025 (GLOBE NEWSWIRE) -- BridgeBio Oncology Therapeutics, Inc. ("BBOT") (Nasdaq: BBOT), a clinical-stage biopharmaceutical company focused on RAS-pathway malignancies, today reported financial results for the third quarter ended September 30, 2025, and provided a business update, including highlights of pipeline progress.
"The third quarter marked an exciting period for BBOT as we made our debut on Nasdaq and welcomed industry veteran Uneek Mehra as our Chief Financial Officer," said Eli Wallace, PhD, Chief Executive Officer of BBOT. "We continue to advance a robust pipeline of next-generation KRAS and PI3K<ALPHA> inhibitors designed to target the RAS pathway, which is one of the most commonly dysregulated in oncology. With three internally discovered clinical assets progressing toward key data readouts in 2026 and a strong financial position expected to fund operations into 2028, we are well positioned to execute on our mission to deliver well-tolerated medicines with improved efficacy and safety for people with the deadliest cancers."
Key Clinical Highlights & Upcoming Milestones
BBO-8520:
-- Continued clinical and operational progress of BBO-8520, an orally
bioavailable small molecule direct inhibitor targeting both the ON and
OFF states of KRAS. OFF-only inhibitors cannot covalently modify the
ON-state; hence they need to maintain high concentration levels to
capture free cycling KRAS G12C. ON/OFF inhibitors overcome this
shortcoming. Dual ON/OFF inhibition allows BBO-8520 to fully capture the
covalent mechanism of action, resulting in sustained pathway inhibition
even after systemic drug levels decline, which we believe may enable a
more potent and safer combination with pembrolizumab in patients with
KRAS G12C mutant non-small cell lung cancer ("NSCLC").
-- BBO-8520 has been shown to drive strong anti-tumor activity with
favorable durability in multiple preclinical models. Early data from
Phase 1 dose escalation showed a 60% confirmed overall response rate in
KRAS G12C NSCLC patients.
-- The U.S. Food and Drug Administration ("FDA") has granted Fast Track
designation to BBO-8520 for the treatment of adult patients with
previously treated, KRAS G12C-mutated metastatic NSCLC.
-- The ongoing Phase 1 ONKORAS-101 trial (NCT06343402) is evaluating
BBO-8520 for patients with KRAS G12C mutant NSCLC. ONKORAS-101 is an
open-label, multi-center Phase 1a/1b study designed to evaluate the
safety, tolerability, preliminary antitumor activity, and
pharmacokinetics of BBO-8520 as a single agent and in combination with
pembrolizumab in patients with KRASG12C mutant NSCLC.
-- Updated clinical data are expected in the first quarter of 2026.
BBO-10203:
-- Continued clinical and operational progress of BBO-10203, an orally
bioavailable small molecule with a novel mechanism of action designed to
inhibit the physical interaction between RAS and PI3K<ALPHA>, inhibiting
RAS-driven PI3K<ALPHA>-AKT signaling in tumors. BBO-10203 binds directly
and covalently to the RAS-binding domain of PI3K<ALPHA>, preventing its
activation by KRAS, HRAS and NRAS, reducing downstream signaling and
tumor growth. It is a protein-protein inhibitor and not a kinase
inhibitor, enabling inhibition of RAS-driven PI3K<ALPHA>-AKT signaling in
tumors without the risk of hyperglycemia. Importantly, BBO-10203's
ability to block RAS activation of PI3K<ALPHA> is agnostic to the
mutational status of either RAS or PI3K<ALPHA>. In addition to a
potentially differentiated safety profile, BBO-10203 could be combined
with direct KRAS inhibitors, such as BBO-8520 and BBO-11818, or drugs
that target HER2 or ER receptors.
-- Preclinical data demonstrated that BBO-10203 blocks RAS-mediated
activation of PI3K<ALPHA> and strongly inhibits pAKT signaling in tumor
cells without affecting glucose metabolism. In addition, robust
monotherapy activity, as well as combination activity with KRAS
inhibitors BBO-8520 and BBO-11818, as well as HER2 inhibitors and ER
antagonists, were observed at well-tolerated dose levels. The combination
of a KRAS inhibitor with a PI3K<ALPHA> pathway inhibitor may maximize the
response rate and reduce the development of adaptive resistance
mechanisms due to full inhibition of both MAPK and PI3K<ALPHA> signaling.
-- The ongoing Phase 1 BREAKER-101 trial (NCT06625775) is evaluating
BBO-10203 for patients with locally advanced or metastatic HER2+ breast
cancer, HR+/HER2- breast cancer, KRAS mutant colorectal cancer, and KRAS
mutant non-small cell lung cancer.
-- Initial Phase 1 clinical data are expected in the first half of 2026.
BBO-11818:
-- Continued clinical and operational progress of BBO-11818, an orally
bioavailable small molecule pan-KRAS inhibitor that targets mutant KRAS
in both the ON and OFF states. Similar to BBO-8520, structure-based
design was employed to target mutant KRAS in both the ON and the OFF
states with strong affinity against KRAS G12D and KRAS G12V mutants.
BBO-11818 has selectivity over HRAS and NRAS with the goal of achieving
high levels of KRAS inhibition in human tumors. In addition, it has
combination potential with BBO-10203 to mitigate the PI3K<ALPHA>
resistance pathway.
-- Preclinical data demonstrated suppression of MAPK signaling and viability
in KRAS mutant cell lines, as well as anti-tumor activity across multiple
KRAS G12D and KRAS G12V cell-derived xenograft $(CDX)$ models. In addition,
BBO-11818's selectivity for KRAS was demonstrated by its >1000-fold lower
potency against NRAS, HRAS, and BRAF-mutant cell lines. The preclinical
activity of the combination of BBO-11818 with BBO-10203 was driven by a
robust decrease in tumor cell proliferation and an increase in apoptosis;
a combination benefit was also observed with cetuximab and anti-PD-1
treatment.
-- The ongoing Phase 1 KONQUER-101 (NCT06917079) trial is evaluating
BBO-11818 for patients with locally advanced or metastatic KRAS mutant
solid tumors.
-- Initial Phase 1 clinical data are expected in the second half of 2026.
Other Key Corporate Updates
-- In July, BBOT announced the appointment of Uneek Mehra as Chief Financial
Officer. Mr. Mehra brings more than 28 years of global financial and
business leadership experience across the biotechnology and
pharmaceutical industries.
-- In August, BBOT announced the closing of its previously announced
business combination with Helix Acquisition Corp. II (formerly Nasdaq:
HLXB) ("Helix"), a special purpose acquisition company ("SPAC") sponsored
by affiliates of Cormorant Asset Management, LP. The business combination
was approved by Helix's shareholders on August 4, 2025, and closed on
August 11, 2025. On August 12, 2025, BBOT began trading under the new
ticker symbol "BBOT" on the Nasdaq Global Market.
Third Quarter 2025 Financial Results
-- Cash Position: As of September 30, 2025, BBOT had cash, cash equivalents
and marketable securities totaling $468.3 million, which is expected to
provide cash runway into 2028.
-- Research and development (R&D) expenses: R&D expenses were $35.1
million for the third quarter of 2025 compared to $17.9 million for the
third quarter of 2024. The increase in expenses was primarily due to
increases in clinical trial expenses and manufacturing expenses for
BBO-8520, BBO-10203 and BBO-11818.
-- General and administrative (G&A) expenses: G&A expenses were $14.1
million for the third quarter of 2025 compared to $1.8 million for the
third quarter of 2024. Changes in G&A expenses reflect the initiation of
BBOT's standalone operations and de-SPAC transaction.
-- Net Loss: Net loss was $44.8 million for the third quarter of 2025
compared to $17.3 million for the third quarter of 2024.
About BBOT
BBOT is a clinical-stage biopharmaceutical company advancing a next-generation pipeline of novel small molecule therapeutics targeting RAS and PI3K<ALPHA> malignancies. BBOT has the goal of improving outcomes for patients with cancers driven by the two most prevalent oncogenes in human tumors. For more information, please visit www.bbotx.com and follow us on LinkedIn.
Forward-Looking Statements
This press release contains forward-looking statements within the meaning of the U.S. Private Securities Litigation Reform Act of 1995, as amended, and other federal securities laws. Any statements in this press release that are not historical facts may be deemed forward-looking statements, which generally are accompanied by words such as "believe," "may," "will," "estimate," "continue," "anticipate," "intend," "expect," "should," "would," "plan," "predict," "potential," "seem," "seek," "future," "outlook" and similar expressions that predict or indicate future events or trends. These forward-looking statements include, without limitation, statements regarding the therapeutic potential and safety profile of BBOT's product candidates, including BBO-8520, BBO-10203 and BBO-11818, the design and conduct of clinical trials with BBOT's product candidates, including expected timelines for clinical data readouts, ongoing and planned regulatory interactions and BBOT's beliefs, expectations and assumptions regarding the future of its business, future plans and strategies, including statements regarding anticipated operating expenses, BBOT's cash runway and sufficiency of its cash and cash equivalents to fund its operations.
These statements are based on various assumptions, whether or not identified in this press release, and are the current expectations of BBOT's management and are not predictions of actual performance. Many actual events and circumstances are beyond the control of BBOT. These forward-looking statements are subject to a number of risks and uncertainties, including changes in domestic and foreign business, market, financial, political, and legal conditions; risks relating to the uncertainty of the projected financial information with respect to BBOT; risks related to the preclinical and clinical development of BBOT's product candidates, including BBO-8520, BBO-10203 and BBO-11818, and the timing of expected regulatory and business milestones, including the progress of enrollment in clinical trials and availability of data from ongoing and planned clinical trials; the impact of competitive products; risks relating to BBOT's ability to obtain sufficient supply of materials; and those factors discussed in documents BBOT has filed or will file with the U.S. Securities and Exchange Commission.
In addition, forward-looking statements reflect BBOT's expectations, plans, or forecasts of future events and views as of the date of this press release and are qualified in their entirety by reference to the cautionary statements herein. BBOT anticipates that subsequent events and developments will cause BBOT's assessments to change. These forward-looking statements should not be relied upon as any guarantee, assurance, prediction or definitive statement of fact or probability or as representing BBOT's assessments as of any date subsequent to the date of this press release. Neither BBOT, nor its affiliates undertake any obligation to update these forward-looking statements, except as required by law.
BBOT Contacts:
Investor Contact:
Heather Armstrong, Head of Investor Relations
BBOT
Investors@BBOTx.com
Media Contact:
Jake Robison
Inizio Evoke Comms
Jake.robison@inizioevoke.com
BridgeBio Oncology Therapeutics, Inc.
Statements of Operations
(Unaudited)
(in thousands, except share and per share amounts)
For the Three Months For the Nine Months Ended
Ended September 30, September 30,
------------------------ -------------------------
2025 2024 2025 2024
----------- ----------- ----------- ------------
Operating
expenses:
Research and
development 35,052 17,889 83,125 53,567
General and
administrative 14,129 1,775 19,286 5,417
---------- ---------- ---------- -----------
Total
operating
expenses 49,181 19,664 102,411 58,984
---------- ---------- ---------- -----------
Loss from
operations (49,181) (19,664) (102,411) (58,984)
Total other
income
(expense),
net 4,424 2,341 7,164 4,396
---------- ---------- ---------- -----------
Net loss $ (44,757) $ (17,323) $ (95,247) $ (54,588)
========== ========== ========== ===========
Net loss per share
attributable to
common
stockholders,
basic and diluted $ (1.03) $(1,562.18) $ (6.49) $ (4,922.72)
========== ========== ========== ===========
Weighted-average
number of shares
used in computing
net loss per share
attributable to
common
stockholders,
basic and diluted 43,491,085 11,089 14,684,990 11,089
========== ========== ========== ===========
Balance Sheet
(Unaudited)
(in thousands)
September 30, December 31,
2025 2024
--------------- --------------
Cash and cash equivalents and marketable
securities $ 468,285 $ 155,631
Total assets 484,793 164,301
Total liabilities 38,093 19,580
Accumulated deficit (317,770) (222,523)
Total stockholders' equity (deficit) 446,700 (178,637)
(END) Dow Jones Newswires
November 12, 2025 16:05 ET (21:05 GMT)
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