Galmed Pharmaceuticals Unveils Promising Synergistic Results for Aramchol, Stivarga, and Metformin in GI Cancer Models

Reuters11-17

Galmed Pharmaceuticals Unveils Promising Synergistic Results for Aramchol, Stivarga, and Metformin in GI Cancer Models

Galmed Pharmaceuticals Ltd. has announced top-line results from preclinical studies evaluating a three-drug combination of Aramchol, Stivarga® (regorafenib), and metformin for gastrointestinal (GI) cancers. The studies demonstrated a synergistic effect in enhancing GI tumor cell killing both in vivo and in vitro. Galmed reported that this combination has the potential to serve as a new fixed-dose treatment, which could extend the commercial lifecycle of Stivarga® as its main patents are set to expire in Europe in August 2028 and in the U.S. in July 2032. New patent applications have been submitted to the USPTO. The company plans to initiate a Phase 1b clinical trial at Virginia Commonwealth University Massey Comprehensive Cancer Center in early 2026, targeting metastatic colorectal cancer, hepatocellular carcinoma, and cholangiocarcinoma, with a planned expansion cohort including metformin. The results from this clinical study have not yet been presented.

Disclaimer: This news brief was created by Public Technologies (PUBT) using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Galmed Pharmaceuticals Ltd. published the original content used to generate this news brief via PR Newswire (Ref. ID: LN26031) on November 17, 2025, and is solely responsible for the information contained therein.

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