Eledon Pharmaceuticals Reports Promising Early Results for Tegoprubart in Islet Transplant Trial for Type 1 Diabetes

Reuters11-19

Eledon Pharmaceuticals Reports Promising Early Results for Tegoprubart in Islet Transplant Trial for Type 1 Diabetes

Eledon Pharmaceuticals Inc. has announced preliminary results from an ongoing investigator-initiated clinical trial evaluating tegoprubart, an investigational anti-CD40 Ligand (anti-CD40L) antibody, as the core immunosuppressant in islet transplantation for individuals with type 1 diabetes. The trial, conducted at the University of Chicago Medicine's Transplant Institute, is assessing a tacrolimus-free immunosuppression regimen to prevent islet transplant rejection. Preliminary data from the first six patients were presented at the Rachmiel Levine-Arthur Riggs Diabetes Research Symposium, held November 14-17, 2025, at City of Hope in Los Angeles, California. All six subjects in the preliminary cohort achieved insulin independence. The study is funded by Breakthrough T1D, which has also committed to support further research on tegoprubart in this context.

Disclaimer: This news brief was created by Public Technologies (PUBT) using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Eledon Pharmaceuticals Inc. published the original content used to generate this news brief via GlobeNewswire (Ref. ID: GNW9578266-en) on November 18, 2025, and is solely responsible for the information contained therein.

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The trial, conducted at the University of Chicago Medicine's Transplant Institute, is assessing a tacrolimus-free immunosuppression regimen to prevent islet transplant rejection. Preliminary data from the first six patients were presented at the Rachmiel Levine-Arthur Riggs Diabetes Research Symposium, held November 14-17, 2025, at City of Hope in Los Angeles, California. All six subjects in the preliminary cohort achieved insulin independence. The study is funded by Breakthrough T1D, which has also committed to support further research on tegoprubart in this context.\n      </p>\n</div><div xmlns:xsd=\"http://www.w3.org/2001/XMLSchema\" xmlns:xsi=\"http://www.w3.org/2001/XMLSchema-instance\">\n<em>Disclaimer: <span>This news brief was created by Public Technologies (PUBT) using generative artificial intelligence. 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The trial, conducted at the University of Chicago Medicine's Transplant Institute, is assessing a tacrolimus-free immunosuppression regimen to prevent islet transplant rejection. Preliminary data from the first six patients were presented at the Rachmiel Levine-Arthur Riggs Diabetes Research Symposium, held November 14-17, 2025, at City of Hope in Los Angeles, California. All six subjects in the preliminary cohort achieved insulin independence. The study is funded by Breakthrough T1D, which has also committed to support further research on tegoprubart in this context.\n      \n\nDisclaimer: This news brief was created by Public Technologies (PUBT) using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. 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