Jacobio Pharmaceuticals Group Co. Ltd. announced that the results of a Phase I/IIa clinical study evaluating its self-developed KRAS G12C inhibitor, glecirasib, in combination with the SHP2 inhibitor JAB-3312 (sitneprotafib), have been published in The Lancet Respiratory Medicine. The open-label study, conducted in China, enrolled 171 patients. This marks the first published comprehensive clinical data of an all-oral KRAS G12C and SHP2 inhibitor combination in a leading medical journal.
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