Regeneron and Tessera Partner to Develop Gene Therapy for Alpha-1 Antitrypsin Deficiency

Reuters12-01

Regeneron and Tessera Partner to Develop Gene Therapy for Alpha-1 Antitrypsin Deficiency

Regeneron Pharmaceuticals Inc. has announced a global collaboration with Tessera Therapeutics to jointly develop and commercialize TSRA-196, an investigational gene editing therapy for alpha-1 antitrypsin deficiency (AATD). Under the agreement, Tessera will receive $150 million, including a cash upfront payment and equity investment from Regeneron, and is eligible for up to $125 million in additional milestone payments. The companies will share worldwide development costs and future profits equally. Tessera will lead the initial clinical trial of TSRA-196, while Regeneron will oversee subsequent global development and commercialization. TSRA-196 is designed as a one-time treatment to precisely correct the genetic mutation underlying AATD, with clinical trial applications expected to be filed by the end of the year.

Disclaimer: This news brief was created by Public Technologies (PUBT) using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Regeneron Pharmaceuticals Inc. published the original content used to generate this news brief via GlobeNewswire (Ref. ID: GNW9594129-en) on December 01, 2025, and is solely responsible for the information contained therein.

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