Syndax Reports Revumenib Achieves 92% Complete Remission Rate in Newly Diagnosed AML Trial

Reuters12-08

Syndax Reports Revumenib Achieves 92% Complete Remission Rate in Newly Diagnosed AML Trial

Syndax Pharmaceuticals Inc. announced new clinical data on its FDA-approved menin inhibitor, Revuforj® (revumenib), at the 67th American Society of Hematology $(ASH)$ Annual Meeting held in Orlando, Florida, from December 6-9, 2025. The presented results include findings from multiple studies spanning the acute leukemia treatment continuum. Key data highlights include a Phase 1 trial of revumenib combined with intensive chemotherapy in newly diagnosed NPM1m and KMT2Ar AML patients, which showed a 92% composite complete remission rate (CRc; 24/26). Additional real-world evidence demonstrated a 77% overall response rate and favorable tolerability among primarily relapsed/refractory NPM1m, KMT2Ar, and NUP98r acute leukemia patients. The company also reported positive outcomes in post-hematopoietic stem cell transplant maintenance and in combination therapies with venetoclax/HMA in newly diagnosed patients. These results were presented at the ASH meeting and are available for replay on the company's website.

Disclaimer: This news brief was created by Public Technologies (PUBT) using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Syndax Pharmaceuticals Inc. published the original content used to generate this news brief via GlobeNewswire (Ref. ID: GNW9598236-en) on December 08, 2025, and is solely responsible for the information contained therein.

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