TuHURA Biosciences Unveils Delta Opioid Receptor Inhibitor to Overcome Cancer Immunotherapy Resistance

Reuters12-08

TuHURA Biosciences Unveils Delta Opioid Receptor Inhibitor to Overcome Cancer Immunotherapy Resistance

TuHURA Biosciences, Inc. announced the presentation of new research on the Delta Opioid Receptor (DOR) as a novel target for overcoming acquired resistance to cancer immunotherapy. The results were presented at the 67th American Society of Hematology $(ASH)$ Annual Meeting and Exposition. The company reported that DOR is expressed on tumor-associated myeloid-derived suppressor cells (MDSCs) and tumor-associated macrophages (TAMs), and that inhibition of DOR reduces the immunosuppressive capabilities of these cells. TuHURA also highlighted the development of a library of selective and potent DOR antagonists and plans to advance a lead antibody drug conjugate $(ADC)$ candidate consisting of a DOR inhibitor linked to a VISTA inhibiting antibody. The company stated that these ADCs have the potential to modulate the tumor microenvironment and support immune recognition of leukemic cells.

Disclaimer: This news brief was created by Public Technologies (PUBT) using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Tuhura Biosciences Inc. published the original content used to generate this news brief via PR Newswire (Ref. ID: LA40981) on December 08, 2025, and is solely responsible for the information contained therein.

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