ADRs Close Lower; Quoin Pharmaceuticals Ltd. Declines 36%

Dow Jones12-06

This article was automatically generated by Dow Jones using technology from Automated Insights.

International stocks trading in New York closed lower on Friday, as the S&P/BNY Mellon index of American depositary receipts declined 0.3% to 232.31.

The European index dropped 0.5% to 204.74. The Asian index gained 0.4% to 310.61. The Latin American index fell 4.2% to 234.96, while the emerging-markets index was flat at 518.38.

Quoin Pharmaceuticals Ltd., based in Israel, posted the largest decline, cratering 36% to $12.09, followed by shares of China's Adlai Nortye Ltd., which tumbled 16% to $1.01. Shares of China-based Akso Health Group tumbled 11% to $1.39.

China's PomDoctor Ltd. was the biggest leader during the session, jumping 15% to $5.45, and Israel-based SaverOne 2014 Ltd. surged 13% to $1.07. Concord Medical Services Holdings Ltd., which is based in China, rounded out the top three leaders on Friday, with shares surging 13% to $3.99.

Data source: Dow Jones Market Data, FactSet

(END) Dow Jones Newswires

December 05, 2025 16:30 ET (21:30 GMT)

Copyright (c) 2025 Dow Jones & Company, Inc.

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The Latin American index fell 4.2% to 234.96, while the emerging-markets index was flat at 518.38. \n</p>\n<p>\n     <a href=\"https://laohu8.com/S/QNRX\">Quoin Pharmaceuticals</a> Ltd., based in Israel, posted the largest decline, cratering 36% to $12.09, followed by shares of China's <a href=\"https://laohu8.com/S/ALN\">Adlai Nortye Ltd.</a>, which tumbled 16% to $1.01. Shares of China-based <a href=\"https://laohu8.com/S/AHG\">Akso Health Group</a> tumbled 11% to $1.39. \n</p>\n<p>\n     China's PomDoctor Ltd. was the biggest leader during the session, jumping 15% to $5.45, and Israel-based SaverOne 2014 Ltd. surged 13% to $1.07. 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The Latin American index fell 4.2% to 234.96, while the emerging-markets index was flat at 518.38. \n\n\nQuoin Pharmaceuticals Ltd., based in Israel, posted the largest decline, cratering 36% to $12.09, followed by shares of China's Adlai Nortye Ltd., which tumbled 16% to $1.01. Shares of China-based Akso Health Group tumbled 11% to $1.39. \n\n\n     China's PomDoctor Ltd. was the biggest leader during the session, jumping 15% to $5.45, and Israel-based SaverOne 2014 Ltd. surged 13% to $1.07. Concord Medical Services Holdings Ltd., which is based in China, rounded out the top three leaders on Friday, with shares surging 13% to $3.99. \n\n\n  Data source: Dow Jones Market Data, FactSet \n\n\n \n\n\n  (END) Dow Jones Newswires\n\n\n  December 05, 2025 16:30 ET (21:30 GMT)\n\n\n  Copyright (c) 2025 Dow Jones & Company, Inc.","kind":"highlight","is_publish_news":true,"is_publish_highlight":false,"is_publish_live":false,"is_publish_wemedia":null,"editions":null,"column":"","sentiment":"-2","news_tag":"","news_rank":0,"symbols":[],"gpt_button":0,"need_auth":true,"code":"91000000","status":"200"},"commentList":[],"isCommentEnd":true,"newsSizeData":{"likeSize":0,"commentSize":0,"repostSize":0,"favoriteSize":0,"likeStatus":false,"favoriteStatus":false},"APP":{"userAgent":"Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)","isDev":false,"isTTM":true,"deviceId":"web-server-community-laohu8-v3","version":"4.35.12","shortVersion":"4.35.12","platform":"web","vendor":"web","appName":"ttm","isIOS":false,"isAndroid":false,"isTiger":false,"isTHS":false,"isWeiXin":false,"isWeiXinMini":false,"isWeiBo":false,"isQQ":false,"isBaiduSwan":false,"isBaiduBox":false,"isDingTalk":false,"isToutiao":false,"isOnePlus":false,"isHuaWei":false,"isXiaomi":false,"isXiaomiWebView":false,"isOppo":false,"isVivo":false,"isSamsung":false,"isMobile":false},"href":"/m/news/2589781062","isCrawlerRequest":true}