Eli Lilly's Jaypirca Outperforms Imbruvica in Phase 3 CLL Trial

Reuters12-08 05:30

Eli Lilly's Jaypirca Outperforms Imbruvica in Phase 3 CLL Trial

Eli Lilly and Company has announced results from the Phase 3 BRUIN CLL-314 clinical trial evaluating Jaypirca (pirtobrutinib), a non-covalent Bruton tyrosine kinase (BTK) inhibitor, compared to Imbruvica (ibrutinib), a covalent BTK inhibitor, in patients with chronic lymphocytic leukemia or small lymphocytic lymphoma (CLL/SLL) who were either treatment-naïve or BTK inhibitor-naïve. Pirtobrutinib met its primary endpoint of non-inferiority for overall response rate $(ORR)$ compared to ibrutinib, with an ORR of 87.0% versus 78.5% in the intent-to-treat population. Progression-free survival data were described as immature but showed a trend favoring pirtobrutinib, including a 76% reduction in the risk of disease progression or death in the treatment-naïve subgroup. These findings will be presented at the 67th American Society of Hematology $(ASH)$ Annual Meeting and Exposition and published in the Journal of Clinical Oncology.

Disclaimer: This news brief was created by Public Technologies (PUBT) using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Eli Lilly and Company published the original content used to generate this news brief via PR Newswire (Ref. ID: DE39886) on December 07, 2025, and is solely responsible for the information contained therein.

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Pirtobrutinib met its primary endpoint of non-inferiority for overall response rate <a href=\"https://laohu8.com/S/ORR\">$(ORR)$</a> compared to ibrutinib, with an ORR of 87.0% versus 78.5% in the intent-to-treat population. Progression-free survival data were described as immature but showed a trend favoring pirtobrutinib, including a 76% reduction in the risk of disease progression or death in the treatment-naïve subgroup. These findings will be presented at the 67th American Society of Hematology <a href=\"https://laohu8.com/S/ASH\">$(ASH)$</a> Annual Meeting and Exposition and published in the Journal of Clinical Oncology.\n      </p>\n</div><div xmlns:xsd=\"http://www.w3.org/2001/XMLSchema\" xmlns:xsi=\"http://www.w3.org/2001/XMLSchema-instance\">\n<em>Disclaimer: <span>This news brief was created by Public Technologies (PUBT) using generative artificial intelligence. 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Pirtobrutinib met its primary endpoint of non-inferiority for overall response rate <a href=\"https://laohu8.com/S/ORR\">$(ORR)$</a> compared to ibrutinib, with an ORR of 87.0% versus 78.5% in the intent-to-treat population. Progression-free survival data were described as immature but showed a trend favoring pirtobrutinib, including a 76% reduction in the risk of disease progression or death in the treatment-naïve subgroup. These findings will be presented at the 67th American Society of Hematology <a href=\"https://laohu8.com/S/ASH\">$(ASH)$</a> Annual Meeting and Exposition and published in the Journal of Clinical Oncology.\n      </p>\n</div><div xmlns:xsd=\"http://www.w3.org/2001/XMLSchema\" xmlns:xsi=\"http://www.w3.org/2001/XMLSchema-instance\">\n<em>Disclaimer: <span>This news brief was created by Public Technologies (PUBT) using generative artificial intelligence. 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ID: DE39886) on December 07, 2025, and is solely responsible for the information contained therein.</span></em>\n</div></body></html>\n\n</article>\n</div>\n</body>\n</html>\n","isBrief":false,"type":0,"news_type":1,"symbol":"LU2491049909.HKD","symbol_name":"WELLINGTON SUSTAINABLE OUTCOMES \"A\" (HKD) ACC","start_time":0,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20251207:nNDLbpM8sb:1","article_id":"2589806600","we_media_id":"1032215980","thumbnails":[],"rights":null,"url":"https://stock-news.laohu8.com/highlight/detail?id=2589806600","pubTimestamp":1765143017,"columns":[],"sourceInfo":null,"weMediaInfo":{"media_name":"Reuters","introduction":"Reuters.com brings you the latest news from around the world, covering breaking news in markets, business, politics, entertainment and technology","home_visible":1,"id":"1032215980","head_image":"https://community-static.tradeup.com/news/4567337cbdf294b657b1fa87c5488b48"},"summary":"Eli Lilly and Company has announced results from the Phase 3 BRUIN CLL-314 clinical trial evaluating Jaypirca , a non-covalent Bruton tyrosine kinase  inhibitor, compared to Imbruvica , a covalent BTK inhibitor, in patients with chronic lymphocytic leukemia or small lymphocytic lymphoma  who were either treatment-nave or BTK inhibitor-nave. Pirtobrutinib met its primary endpoint of non-inferiority for overall response rate  compared to ibrutinib, with an ORR of 87.0% versus 78.5% in the intent-to-treat population. Progression-free survival data were described as immature but showed a trend favoring pirtobrutinib, including a 76% reduction in the risk of disease progression or death in the treatment-nave subgroup. These findings will be presented at the 67th American Society of Hematology  Annual Meeting and Exposition and published in the Journal of Clinical Oncology.Disclaimer: This news brief was created by Public Technologies  using generative artificial intelligence. 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Global Dynamic Dividend A MIncA USD","IE0004445015.USD":"JANUS HENDERSON BALANCED \"A2\" (USD) ACC","LU2468319806.SGD":"MANULIFE GF HEALTHCARE \"AA\" (SGDHDG) ACC","LU2237443549.SGD":"Aberdeen Standard SICAV I - Global Dynamic Dividend A MIncA SGD-H","LU1093756325.SGD":"FTIF - Franklin K2 Alt Strat Fd A (acc) SGD-H1","LU0289739699.SGD":"AB INTERNATIONAL HEALTH CARE PORTFOLIO \"A\" (SGD) ACC","LU2237443895.HKD":"abrdn SICAV I -  GLOBAL DYNAMIC DIVIDEND \"A\" (HKD) ACC","LU2237443622.USD":"Aberdeen Standard SICAV I - Global Dynamic Dividend A Acc USD","LU1093756168.USD":"FRANKLIN K2 ALTERNATIVE STRATEGIES \"A\" (USD) ACC","IE00BJT1NW94.SGD":"JANUS HENDERSON GLOBAL LIFE SCIENCES \"A2\" (SGDHDG) ACC","LU2023250504.SGD":"Allianz Thematica Cl AMg DIS H2-SGD"},"translate_title":"礼来公司的Jaypirca在3期CLL试验中优于Imbruvica","themeId":null,"isJumpTheme":false,"ttsUrl":null,"symbols_score_info":{"LLY":1.96},"content_text":"Eli Lilly's Jaypirca Outperforms Imbruvica in Phase 3 CLL Trial\n    \n\n        Eli Lilly and Company has announced results from the Phase 3 BRUIN CLL-314 clinical trial evaluating Jaypirca (pirtobrutinib), a non-covalent Bruton tyrosine kinase (BTK) inhibitor, compared to Imbruvica (ibrutinib), a covalent BTK inhibitor, in patients with chronic lymphocytic leukemia or small lymphocytic lymphoma (CLL/SLL) who were either treatment-naïve or BTK inhibitor-naïve. Pirtobrutinib met its primary endpoint of non-inferiority for overall response rate $(ORR)$ compared to ibrutinib, with an ORR of 87.0% versus 78.5% in the intent-to-treat population. Progression-free survival data were described as immature but showed a trend favoring pirtobrutinib, including a 76% reduction in the risk of disease progression or death in the treatment-naïve subgroup. These findings will be presented at the 67th American Society of Hematology $(ASH)$ Annual Meeting and Exposition and published in the Journal of Clinical Oncology.\n      \n\nDisclaimer: This news brief was created by Public Technologies (PUBT) using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Eli Lilly and Company published the original content used to generate this news brief via PR Newswire (Ref. ID: DE39886) on December 07, 2025, and is solely responsible for the information contained therein.","kind":"highlight","is_publish_news":true,"is_publish_highlight":false,"is_publish_live":false,"is_publish_wemedia":null,"editions":null,"column":"","sentiment":"1","news_tag":"productRelease","news_rank":0,"symbols":[],"gpt_button":0,"need_auth":false,"code":"91000000","status":"200"},"commentList":[],"isCommentEnd":true,"newsSizeData":{"likeSize":0,"commentSize":0,"repostSize":0,"favoriteSize":0,"likeStatus":false,"favoriteStatus":false},"APP":{"userAgent":"Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)","isDev":false,"isTTM":true,"deviceId":"web-server-community-laohu8-v3","version":"4.35.10","shortVersion":"4.35.10","platform":"web","vendor":"web","appName":"ttm","isIOS":false,"isAndroid":false,"isTiger":false,"isTHS":false,"isWeiXin":false,"isWeiXinMini":false,"isWeiBo":false,"isQQ":false,"isBaiduSwan":false,"isBaiduBox":false,"isDingTalk":false,"isToutiao":false,"isOnePlus":false,"isHuaWei":false,"isXiaomi":false,"isXiaomiWebView":false,"isOppo":false,"isVivo":false,"isSamsung":false,"isMobile":false},"href":"/m/news/2589806600","isCrawlerRequest":true}