Biogen Unveils Promising Clinical Data for Zorevunersen in Dravet Syndrome Treatment

Reuters12-05

Biogen Unveils Promising Clinical Data for Zorevunersen in Dravet Syndrome Treatment

Biogen Inc. and Stoke Therapeutics have announced new data presentations supporting the potential of zorevunersen, an investigational antisense oligonucleotide, as a disease-modifying treatment for Dravet syndrome. The results were presented at the 2025 American Epilepsy Society $(AES)$ Annual Meeting. Findings from long-term Phase 1/2a and open-label extension studies showed durable reductions in seizures, increased seizure-free days, and improvements in cognition, behavior, and quality of life for patients receiving zorevunersen in addition to standard anti-seizure medications. Analysis of electroencephalogram (EEG) data supports a disease-modifying mechanism of action. A propensity score weighted analysis comparing zorevunersen treatment to the natural history of the disease also demonstrated reductions in seizures and improvements in cognition and behavior at dose levels and timepoints consistent with the ongoing Phase 3 EMPEROR study. Long-term safety data indicated that some patients received up to 15 doses over more than four years.

Disclaimer: This news brief was created by Public Technologies (PUBT) using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Biogen Inc. published the original content used to generate this news brief via GlobeNewswire (Ref. ID: GNW9597476-en) on December 05, 2025, and is solely responsible for the information contained therein.

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