TransThera Sciences Reports Positive Phase 2 Results for Tinengotinib in Cholangiocarcinoma

Reuters12-05 12:32

TransThera Sciences Reports Positive Phase 2 Results for Tinengotinib in Cholangiocarcinoma

TransThera Sciences (Nanjing) Inc. has announced the publication of clinical results from a US-based Phase 2 trial evaluating tinengotinib (TT-00420) in patients with cholangiocarcinoma $(CCA)$. The findings have been published in The Lancet Gastroenterology and Hepatology. The multicenter, open-label Phase 2 trial enrolled patients with FGFR2 fusion-positive CCA who had demonstrated resistance to prior FGFR inhibitor therapy, as well as patients with other FGFR alterations and FGFR wild-type tumors. Tinengotinib demonstrated clinical activity, including durable responses and meaningful clinical benefit, in patients with FGFR2 fusion-positive CCA with acquired resistance to FGFR inhibitors, as well as in other FGFR-altered subtypes. The results support further clinical investigation in a Phase 3 registration study.

Disclaimer: This news brief was created by Public Technologies (PUBT) using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Transthera Sciences (Nanjing) Inc. published the original content used to generate this news brief via PR Newswire (Ref. ID: CN40050) on December 05, 2025, and is solely responsible for the information contained therein.

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While PUBT strives to provide accurate and timely information, this AI-generated content is fo","collect":0,"end_time":0,"defaultTopTitle":"","property":[],"viewcount":null,"language":"en","relate_stocks":{"02617":"药捷安康-B","BK1161":"生物科技"},"translate_title":"TransThera Sciences报告Tinengotinib治疗胆管癌的积极2期结果","themeId":null,"isJumpTheme":false,"ttsUrl":null,"symbols_score_info":{"02617":0.9},"content_text":"TransThera Sciences Reports Positive Phase 2 Results for Tinengotinib in Cholangiocarcinoma\n    \n\n        TransThera Sciences (Nanjing) Inc. has announced the publication of clinical results from a US-based Phase 2 trial evaluating tinengotinib (TT-00420) in patients with cholangiocarcinoma $(CCA)$. The findings have been published in The Lancet Gastroenterology and Hepatology. 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