Crinetics Pharmaceuticals Doses First Patient in Phase 3 Atumelnant Trial for Congenital Adrenal Hyperplasia

Reuters12-12

Crinetics Pharmaceuticals Doses First Patient in Phase 3 Atumelnant Trial for Congenital Adrenal Hyperplasia

Crinetics Pharmaceuticals Inc. announced the initiation of the CALM-CAH Phase 3 clinical trial evaluating atumelnant, an investigational oral adrenocorticotropic hormone (ACTH) receptor antagonist, for the treatment of classic congenital adrenal hyperplasia $(CAH)$ in adults. The first patient has been dosed in this pivotal, randomized, placebo-controlled study, which aims to assess atumelnant's ability to reduce excess adrenal androgens and improve glucocorticoid use. The trial builds on positive results from a previous Phase 2 study, which demonstrated reductions in key disease biomarkers and other clinical measures. Results from the Phase 3 study will be presented in the future.

Disclaimer: This news brief was created by Public Technologies (PUBT) using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Crinetics Pharmaceuticals Inc. published the original content used to generate this news brief via GlobeNewswire (Ref. ID: GNW9601000-en) on December 11, 2025, and is solely responsible for the information contained therein.

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