Tenaya Therapeutics Reports Positive Interim Results for TN-401 Gene Therapy in ARVC Trial

Reuters12-12

Tenaya <a href="https://laohu8.com/S/LENZ">Therapeutics</a> Reports Positive Interim Results for TN-401 Gene Therapy in ARVC Trial

Tenaya Therapeutics Inc. announced positive interim results from Cohort 1 of the ongoing RIDGE-1 Phase 1b/2 clinical trial evaluating TN-401 gene therapy for adults with PKP2-associated arrhythmogenic right ventricular cardiomyopathy (ARVC). According to the company, TN-401 was well tolerated at the 3E13 vg/kg dose, with robust gene transduction and increased PKP2 protein levels observed in the first two patients at week 8. Clinically meaningful reductions in arrhythmia burden were reported in the first two patients with more than six months of follow-up. Tenaya Therapeutics plans to present these preliminary results during a webcast conference call on December 11, 2025.

Disclaimer: This news brief was created by Public Technologies (PUBT) using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Tenaya Therapeutics Inc. published the original content used to generate this news brief via GlobeNewswire (Ref. ID: GNW9601039-en) on December 11, 2025, and is solely responsible for the information contained therein.

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