Enterprise Therapeutics, a portfolio company of IP Group plc, has published results from its Phase 1 clinical trial of ETD001, a novel inhaled epithelial sodium channel (ENaC) blocker for the treatment of cystic fibrosis. The study, published in The Journal of Cystic Fibrosis, demonstrated that ETD001 was well tolerated in healthy participants at doses higher than those predicted to be therapeutic, with no significant changes in blood potassium levels observed. The pharmacokinetic profile indicated prolonged lung retention and potential for extended duration of action. A Phase 2 trial of ETD001 in people with cystic fibrosis is currently in progress, with headline data expected in early 2026.
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