Akeso Reports 80% Response Rate for Ivonescimab Plus Chemotherapy in First-Line TNBC Trial

Reuters12-11

Akeso Reports 80% Response Rate for Ivonescimab Plus Chemotherapy in First-Line TNBC Trial

Akeso Inc. has announced updated efficacy data from a Phase II clinical study evaluating ivonescimab, a PD-1/VEGF bispecific antibody, in combination with chemotherapy as a first-line treatment for locally advanced unresectable or metastatic triple-negative breast cancer (TNBC). The results were presented at the 2025 European Society for Medical Oncology Immuno-Oncology Congress (ESMO IO) in London. As of July 15, 2025, 36 patients were enrolled, with the objective response rate $(ORR)$ reported at 80.0% and a disease control rate (DCR) of 100.0%. The median progression-free survival (mPFS) was 15.2 months. The safety profile was favorable, with no treatment-related adverse events leading to discontinuation or death. Overall survival data are not yet mature. A Phase III clinical trial for this indication is currently ongoing.

Disclaimer: This news brief was created by Public Technologies (PUBT) using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Akeso Inc. published the original content used to generate this news brief via PR Newswire (Ref. ID: CN44324) on December 11, 2025, and is solely responsible for the information contained therein.

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