Terns Pharmaceuticals Reports Positive Phase 1 Results for TERN-701 in Relapsed CML

Reuters12-09

Terns Pharmaceuticals Reports Positive Phase 1 Results for TERN-701 in Relapsed CML

Terns Pharmaceuticals Inc. announced updated and expanded Phase 1 clinical data from the ongoing CARDINAL trial of TERN-701, a novel investigational allosteric BCR::ABL1 inhibitor, in patients with previously treated chronic myeloid leukemia (CML). The results were presented at the 67th American Society of Hematology $(ASH)$ Annual Meeting held December 6-9, 2025, in Orlando, FL. The data showed a 64% major molecular response (MMR) achievement rate by 24 weeks among all efficacy evaluable patients, and a 75% MMR rate in patients at doses greater than 320mg QD. A favorable safety and tolerability profile was observed with a median treatment duration of six months. The company hosted an investor update call on December 8, 2025, to discuss additional trial data and next steps for TERN-701's development.

Disclaimer: This news brief was created by Public Technologies (PUBT) using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Terns Pharmaceuticals Inc. published the original content used to generate this news brief via GlobeNewswire (Ref. ID: GNW9598755-en) on December 08, 2025, and is solely responsible for the information contained therein.

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The results were presented at the 67th American Society of Hematology $(ASH)$ Annual Meeting held December 6-9, 2025, in Orlando, FL. The data showed a 64% major molecular response (MMR) achievement rate by 24 weeks among all efficacy evaluable patients, and a 75% MMR rate in patients at doses greater than 320mg QD. A favorable safety and tolerability profile was observed with a median treatment duration of six months. The company hosted an investor update call on December 8, 2025, to discuss additional trial data and next steps for TERN-701's development.\n      \n\nDisclaimer: This news brief was created by Public Technologies (PUBT) using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Terns Pharmaceuticals Inc. published the original content used to generate this news brief via GlobeNewswire (Ref. 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