Sagimet Biosciences Reports Positive Phase 1 Results for Denifanstat and Resmetirom Combination in MASH

Reuters12-18

Sagimet Biosciences Reports Positive Phase 1 Results for Denifanstat and Resmetirom Combination in MASH

Sagimet Biosciences Inc. announced positive results from a Phase 1 pharmacokinetic $(PK)$ clinical trial evaluating the combination of its oral fatty acid synthase (FASN) inhibitor, denifanstat, with the thyroid hormone receptor beta (THR-β) agonist, resmetirom. The study enrolled 40 healthy adult participants and assessed the safety, tolerability, and potential drug-drug interactions of the combination. The results indicated that the combination was generally well-tolerated, with no serious adverse events or treatment discontinuations reported. These Phase 1 results have already been presented, and Sagimet plans to advance the combination into a Phase 2 proof-of-concept efficacy trial for patients with metabolic dysfunction-associated steatohepatitis (MASH) with F4 fibrosis, expected to initiate in the second half of 2026.

Disclaimer: This news brief was created by Public Technologies (PUBT) using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Sagimet Biosciences Inc. published the original content used to generate this news brief via GlobeNewswire (Ref. ID: GNW9604306-en) on December 18, 2025, and is solely responsible for the information contained therein.

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The study enrolled 40 healthy adult participants and assessed the safety, tolerability, and potential drug-drug interactions of the combination. The results indicated that the combination was generally well-tolerated, with no serious adverse events or treatment discontinuations reported. These Phase 1 results have already been presented, and Sagimet plans to advance the combination into a Phase 2 proof-of-concept efficacy trial for patients with metabolic dysfunction-associated steatohepatitis (MASH) with F4 fibrosis, expected to initiate in the second half of 2026.\n      \n\nDisclaimer: This news brief was created by Public Technologies (PUBT) using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. 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