Did JAMA’s “Research of the Year” Spotlight on Lorundrostat Just Shift Mineralys Therapeutics’ (MLYS) Investment Narrative?

Simply Wall St.2025-12-21

In December 2025, Mineralys Therapeutics reported that its Phase 3 Launch-HTN trial of lorundrostat for uncontrolled or treatment-resistant hypertension was featured in JAMA’s inaugural “Research of ...

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This recognition, framed by JAMA as “New Hope for Treatment-Resistant Hypertension,” highlights both the growing clinical interest in aldosterone as a therapeutic target and the breadth of lorundrostat data across four completed trials. We’ll now examine how JAMA’s “Research of the Year” spotlight on lorundrostat could shape Mineralys Therapeutics’ investment narrative and future milestones. AI is about to change healthcare. These 29 stocks are working on everything from early diagnostics to drug discovery. The best part - they are all under $10b in market cap - there's still time to get in early.What Is Mineralys Therapeutics' Investment Narrative?For Mineralys, the big-picture belief is simple: lorundrostat has to move from promising data to an approved, commercially relevant hypertension drug. The JAMA “Research of the Year” nod reinforces the clinical relevance of Launch-HTN and could incrementally strengthen the story around NDA discussions and future partnering or commercialization conversations, but it does not remove the key near-term catalysts or risks. The real swing factors still sit with FDA feedback on the pivotal package, the timing and outcome of the planned NDA submission, and upcoming readouts like EXPLORE-OSA that could broaden the label opportunity. On the risk side, Mineralys remains a single-asset, loss-making biotech with fresh dilution and dependence on third parties for trials and manufacturing, so any regulatory delay or safety concern would matter more than this positive visibility boost. However, there is one concentration risk here that investors should not ignore.\n\nDespite retreating, Mineralys Therapeutics' shares might still be trading above their fair value and there could be some more downside. Discover how much.Exploring Other PerspectivesMLYS 1-Year Stock Price Chart Four Simply Wall St Community fair values span US$10 to US$100, underscoring just how far apart private investors can be. Set that against Mineralys’ reliance on a single late stage asset and the regulatory outcomes that will heavily influence how those valuations age.Explore 4 other fair value estimates on Mineralys Therapeutics - why the stock might be worth over 2x more than the current price!Build Your Own Mineralys Therapeutics NarrativeDisagree with this assessment? Create your own narrative in under 3 minutes - extraordinary investment returns rarely come from following the herd.A great starting point for your Mineralys Therapeutics research is our analysis highlighting 3 key rewards and 4 important warning signs that could impact your investment decision.Our free Mineralys Therapeutics research report provides a comprehensive fundamental analysis summarized in a single visual - the Snowflake - making it easy to evaluate Mineralys Therapeutics' overall financial health at a glance.Ready To Venture Into Other Investment Styles?Don't miss your shot at the next 10-bagger. Our latest stock picks just dropped:The best AI stocks today may lie beyond giants like Nvidia and Microsoft. Find the next big opportunity with these 24 smaller AI-focused companies with strong growth potential through early-stage innovation in machine learning, automation, and data intelligence that could fund your retirement.This technology could replace computers: discover 28 stocks that are working to make quantum computing a reality.We've found 12 US stocks that are forecast to pay a dividend yield of over 6% next year. See the full list for free.  This article by Simply Wall St is general in nature. We provide commentary based on historical data\n    and analyst forecasts only using an unbiased methodology and our articles are not intended to be financial advice. It does not constitute a recommendation to buy or sell any stock, and does not take account of your objectives, or your\n    financial situation. We aim to bring you long-term focused analysis driven by fundamental data.\n    Note that our analysis may not factor in the latest price-sensitive company announcements or qualitative material.\n    Simply Wall St has no position in any stocks mentioned.Mobile Infrastructure for Defense and DisasterThe next wave in robotics isn't humanoid. Its fully autonomous towers delivering 5G, ISR, and radar in under 30 minutes, anywhere.Get the investor briefing before the next round of contractsSponsored On Behalf of CiTechNew: Manage All Your Stock Portfolios in One PlaceWe've created the ultimate portfolio companion for stock investors, and it's free.• Connect an unlimited number of Portfolios and see your total in one currency• Be alerted to new Warning Signs or Risks via email or mobile• Track the Fair Value of your stocksTry a Demo Portfolio for FreeHave feedback on this article? Concerned about the content? Get in touch with us directly. 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