Immunome (IMNM): Assessing Valuation After Strong Phase 3 Varegacestat Data and $400 Million Equity Raise

Simply Wall St.2025-12-26

Immunome (IMNM) just delivered a big one two for investors, first unveiling strong Phase 3 RINGSIDE data for varegacestat in desmoid tumors, then swiftly raising about $400 million through a follow on...

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See our latest analysis for Immunome. Those blockbuster Phase 3 results and the follow on raise have not gone unnoticed, with the share price climbing to $22.33 and delivering a 90 day share price return of about 120 percent, while the three year total shareholder return is nearing 800 percent. This suggests powerful momentum rather than a one day pop. Given how quickly sentiment can shift after big biotech readouts, it could be a smart moment to explore other healthcare names using healthcare stocks for fresh ideas beyond Immunome. With shares still trading at roughly a 45 percent discount to analyst targets despite a multibagger run, is Immunome now a misunderstood growth story to accumulate, or has the market already priced in its future pipeline upside? Price to Book of 7.8x: Is It Justified? Immunome's latest close at $22.33 comes with a rich price to book ratio of 7.8 times, signaling the market is paying a hefty premium versus peers. The price to book multiple compares the market value of the company to its net assets, which is a common yardstick for asset light, loss making biotechs. At 7.8 times, investors are clearly focusing on future pipeline potential rather than current balance sheet value or profitability. However, that premium is steep even by sector standards. Management has guided a business focused on rapidly growing revenue, yet the statements highlight that Immunome is currently unprofitable, is forecast to remain unprofitable over the next three years and has a negative return on equity of 84.4 percent. In that context, a 7.8 times book value suggests the market is aggressively pricing in future success well ahead of earnings visibility. The contrast becomes starker against the wider biotech landscape. Immunome trades at 7.8 times book value compared with the US biotechs industry average of 2.7 times, and also looks expensive versus a narrower peer group average of 6 times. That kind of gap implies investors see Immunome as a standout growth story in its space, but it also leaves less room for disappointment if execution, trial timelines or funding needs do not go exactly to plan. See what the numbers say about this price — find out in our valuation breakdown. Result: Price-to-Book of 7.8x (OVERVALUED) However, setbacks in late stage trials or further dilution from future capital raises could quickly undermine today’s optimism around Immunome’s premium valuation. Find out about the key risks to this Immunome narrative.  Build Your Own Immunome Narrative If you see the numbers differently or want to dig into the data yourself, you can build a fully personalized narrative in minutes using Do it your way. A great starting point for your Immunome research is our analysis highlighting 2 key rewards and 3 important warning signs that could impact your investment decision. Looking for your next high conviction opportunity? Do not stop at one compelling story. Use the Simply Wall St screener to surface fresh, data driven ideas that could upgrade your portfolio’s future returns.  Capture asymmetric upside by targeting early stage names using these 3622 penny stocks with strong financials that already show robust underlying fundamentals and room for rapid re rating. Harness structural growth trends by focusing on these 24 AI penny stocks positioned at the intersection of automation, data and scalable software economics. Identify potential bargains by filtering for these 901 undervalued stocks based on cash flows where market expectations look overly pessimistic relative to their long term cash flow prospects.   This article by Simply Wall St is general in nature. We provide commentary based on historical data\n    and analyst forecasts only using an unbiased methodology and our articles are not intended to be financial advice. It does not constitute a recommendation to buy or sell any stock, and does not take account of your objectives, or your\n    financial situation. We aim to bring you long-term focused analysis driven by fundamental data.\n    Note that our analysis may not factor in the latest price-sensitive company announcements or qualitative material.\n    Simply Wall St has no position in any stocks mentioned.The New Payments ETF Is Live on NASDAQ:Money is moving to real-time rails, and a newly listed ETF now gives investors direct exposure. Fast settlement. Institutional custody. Simple access.Explore how this launch could reshape portfoliosSponsored ContentNew: AI Stock Screener & AlertsOur new AI Stock Screener scans the market every day to uncover opportunities.• Dividend Powerhouses (3%+ Yield)• Undervalued Small Caps with Insider Buying• High growth Tech and AI CompaniesOr build your own from over 50 metrics.Explore Now for FreeHave feedback on this article? Concerned about the content? Get in touch with us directly. 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